PTP1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PTP1_ARATH
• UniProt AC: O82656
• Protein Name: Protein-tyrosine-phosphatase PTP1
• Gene Name: PTP1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 340
• Subcellular Localization: Cytoplasm, cytosol . Nucleus .
• Protein Description: Protein-tyrosine-phosphatase that dephosphorylates and probably inhibits MPK6 in non-oxidative stress conditions. In association with MKP1, represses salicylic acid (SA) and camalexin biosynthesis, thus modulating defense response. May also repress MPK3. Dephosphorylates and inactivates MPK4 in vitro..
• Protein Sequence: MATGKTSSAANLFTGSTRFDLSSADSPPSKLSLSSDQLNHCHQALGVFRGKIQNPDSIAHEFTGLQANRMWPSELLLNSTVAMNSVNVEKNRYSDVVPFDKNRIVLNPCKDSSAKGYVNASLIKTSESESISQFIATQGPLPHTMEDFWEMVIQQHCPIIVMLTRLVDNNRTVKCGDYFQDEDGPREFGNISLTTKWIKTTDTSLMLRNLEVNYKETEDQPMSVLHIQYPEWPDHGVPKDTVAVREILKRLYQVPPSLGPIIVHCSAGIGRTGTYCAIHNTIQRILAGDMSALDLAKTVALFRKQRIGMVQTMDQYFFCYNAIVDELEDLTAGTNAGTSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MATGKTSSAANLF --CCCCCCCHHHHHC	29.29	30407730
7	Phosphorylation	-MATGKTSSAANLFT -CCCCCCCHHHHHCC	22.82	30407730
8	Phosphorylation	MATGKTSSAANLFTG CCCCCCCHHHHHCCC	36.31	17317660
14	Phosphorylation	SSAANLFTGSTRFDL CHHHHHCCCCCEEEC	33.13	19880383
16	Phosphorylation	AANLFTGSTRFDLSS HHHHCCCCCEEECCC	17.22	15308754
17	Phosphorylation	ANLFTGSTRFDLSSA HHHCCCCCEEECCCC	36.38	15308754
23	Phosphorylation	STRFDLSSADSPPSK CCEEECCCCCCCCHH	43.31	25561503
26	Phosphorylation	FDLSSADSPPSKLSL EECCCCCCCCHHCCC	38.13	15308754
29	Phosphorylation	SSADSPPSKLSLSSD CCCCCCCHHCCCCHH	50.00	15308754

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PTP1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PTP1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PTP1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PTP1_ARATH	PTP1	physical	19789277
MPK6_ARATH	MPK6	physical	19789277
MPK3_ARATH	MPK3	physical	19789277
MBP_HUMAN	MBP	physical	22968126

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.