PRIC2_HUMAN - dbPTM
PRIC2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PRIC2_HUMAN
UniProt AC Q7Z3G6
Protein Name Prickle-like protein 2
Gene Name PRICKLE2
Organism Homo sapiens (Human).
Sequence Length 844
Subcellular Localization Nucleus membrane .
Protein Description
Protein Sequence MVTVMPLEMEKTISKLMFDFQRNSTSDDDSGCALEEYAWVPPGLKPEQVHQYYSCLPEEKVPYVNSPGEKLRIKQLLHQLPPHDNEVRYCNSLDEEEKRELKLFSSQRKRENLGRGNVRPFPVTMTGAICEQCGGQINGGDIAVFASRAGHGVCWHPPCFVCTVCNELLVDLIYFYQDGKIYCGRHHAECLKPRCAACDEIIFADECTEAEGRHWHMKHFCCFECETVLGGQRYIMKEGRPYCCHCFESLYAEYCDTCAQHIGIDQGQMTYDGQHWHATETCFCCAHCKKSLLGRPFLPKQGQIFCSRACSAGEDPNGSDSSDSAFQNARAKESRRSAKIGKNKGKTEEPMLNQHSQLQVSSNRLSADVDPLSLQMDMLSLSSQTPSLNRDPIWRSREEPYHYGNKMEQNQTQSPLQLLSQCNIRTSYSPGGQGAGAQPEMWGKHFSNPKRSSSLAMTGHAGSFIKECREDYYPGRLRSQESYSDMSSQSFSETRGSIQVPKYEEEEEEEGGLSTQQCRTRHPISSLKYTEDMTPTEQTPRGSMESLALSNATGLSADGGAKRQEHLSRFSMPDLSKDSGMNVSEKLSNMGTLNSSMQFRSAESVRSLLSAQQYQEMEGNLHQLSNPIGYRDLQSHGRMHQSFDFDGGMAGSKLPGQEGVRIQPMSERTRRRATSRDDNRRFRPHRSRRSRRSRSDNALHLASEREAISRLKDRPPLRAREDYDQFMRQRSFQESMGHGSRRDLYGQCPRTVSDLALQNAFGDRWGPYFAEYDWCSTCSSSSESDNEGYFLGEPIPQPARLRYVTSDELLHKYSSYGLPKSSTLGGRGQLHSRKRQKSKNCIIS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
66PhosphorylationEKVPYVNSPGEKLRI
HHCCCCCCCCHHHHH		25.0025159151
92PhosphorylationNEVRYCNSLDEEEKR
CCCCCCCCCCHHHHH		33.37-
182PhosphorylationFYQDGKIYCGRHHAE
HCCCCEEEECHHHHH		7.7323532336
319PhosphorylationAGEDPNGSDSSDSAF
CCCCCCCCCCCCHHH		40.7424076635
321PhosphorylationEDPNGSDSSDSAFQN
CCCCCCCCCCHHHHH		37.4324076635
322PhosphorylationDPNGSDSSDSAFQNA
CCCCCCCCCHHHHHH		40.3424076635
361PhosphorylationQHSQLQVSSNRLSAD
HHHHHHHCCCCCCCC		14.66-
373PhosphorylationSADVDPLSLQMDMLS
CCCCCHHHHHHHHHH		23.1924719451
385PhosphorylationMLSLSSQTPSLNRDP
HHHHCCCCCCCCCCC		19.4524719451
387PhosphorylationSLSSQTPSLNRDPIW
HHCCCCCCCCCCCCC		41.4824719451
414PhosphorylationMEQNQTQSPLQLLSQ
CCCCCCCCHHHHHHH		30.8528348404
426PhosphorylationLSQCNIRTSYSPGGQ
HHHCCCCCCCCCCCC		28.3728857561
427PhosphorylationSQCNIRTSYSPGGQG
HHCCCCCCCCCCCCC		17.4828857561
428PhosphorylationQCNIRTSYSPGGQGA
HCCCCCCCCCCCCCC		20.4828857561
429PhosphorylationCNIRTSYSPGGQGAG
CCCCCCCCCCCCCCC		19.4828857561
452PhosphorylationHFSNPKRSSSLAMTG
CCCCCCCCCCHHHHC		30.3324275569
453PhosphorylationFSNPKRSSSLAMTGH
CCCCCCCCCHHHHCC		33.1428857561
454PhosphorylationSNPKRSSSLAMTGHA
CCCCCCCCHHHHCCH		22.7628857561
458PhosphorylationRSSSLAMTGHAGSFI
CCCCHHHHCCHHHHH		21.8721214269
463PhosphorylationAMTGHAGSFIKECRE
HHHCCHHHHHHHHHH		25.2828857561
472PhosphorylationIKECREDYYPGRLRS
HHHHHHHCCCCCCCC		13.5521214269
473PhosphorylationKECREDYYPGRLRSQ
HHHHHHCCCCCCCCC		16.1321214269
482PhosphorylationGRLRSQESYSDMSSQ
CCCCCCCCCCCCCCC		23.4628857561
483PhosphorylationRLRSQESYSDMSSQS
CCCCCCCCCCCCCCC		14.1328857561
514PhosphorylationEEEEGGLSTQQCRTR
HHHCCCCCHHHHHCC		27.6924719451
515PhosphorylationEEEGGLSTQQCRTRH
HHCCCCCHHHHHCCC		27.9224719451
520O-linked_GlycosylationLSTQQCRTRHPISSL
CCHHHHHCCCCCCCC		40.7430379171
525PhosphorylationCRTRHPISSLKYTED
HHCCCCCCCCCCCCC		33.7824719451
534PhosphorylationLKYTEDMTPTEQTPR
CCCCCCCCCCCCCCC		39.1028857561
536PhosphorylationYTEDMTPTEQTPRGS
CCCCCCCCCCCCCCC		31.4028857561
539PhosphorylationDMTPTEQTPRGSMES
CCCCCCCCCCCCHHH		14.5525850435
543PhosphorylationTEQTPRGSMESLALS
CCCCCCCCHHHHHHH		22.2129255136
546PhosphorylationTPRGSMESLALSNAT
CCCCCHHHHHHHCCC		15.4228857561
568PhosphorylationAKRQEHLSRFSMPDL
HHHHHHHHHCCCCCC		32.9429514088
571PhosphorylationQEHLSRFSMPDLSKD
HHHHHHCCCCCCCCC		28.4430266825
588PhosphorylationMNVSEKLSNMGTLNS
CCHHHHHHCCCCCCC		35.52-
592PhosphorylationEKLSNMGTLNSSMQF
HHHHCCCCCCCCCHH		16.40-
595PhosphorylationSNMGTLNSSMQFRSA
HCCCCCCCCCHHCCH		30.2428857561
596PhosphorylationNMGTLNSSMQFRSAE
CCCCCCCCCHHCCHH		18.6128857561
601PhosphorylationNSSMQFRSAESVRSL
CCCCHHCCHHHHHHH		37.3627251275
604PhosphorylationMQFRSAESVRSLLSA
CHHCCHHHHHHHHHH		23.6527251275
607PhosphorylationRSAESVRSLLSAQQY
CCHHHHHHHHHHHHH		31.3528348404
610PhosphorylationESVRSLLSAQQYQEM
HHHHHHHHHHHHHHH		29.3527251275
625PhosphorylationEGNLHQLSNPIGYRD
HCCHHHHCCCCCHHH		33.71-
642PhosphorylationSHGRMHQSFDFDGGM
HCCCCCCEECCCCCC		16.4728857561
652PhosphorylationFDGGMAGSKLPGQEG
CCCCCCCCCCCCCCC		22.83-
666PhosphorylationGVRIQPMSERTRRRA
CCCCCCCCHHHHHHC		30.5229255136
693PhosphorylationRSRRSRRSRSDNALH
CCHHHHHHHHHHHHH		34.7223927012
695PhosphorylationRRSRRSRSDNALHLA
HHHHHHHHHHHHHHH		36.1429255136
703PhosphorylationDNALHLASEREAISR
HHHHHHHHHHHHHHH		43.4724719451
731PhosphorylationDQFMRQRSFQESMGH
HHHHHHHHHHHHHCC		23.9628857561
740PhosphorylationQESMGHGSRRDLYGQ
HHHHCCCCHHHHCCC		20.6125849741
751PhosphorylationLYGQCPRTVSDLALQ
HCCCCCCHHHHHHHH		14.9830266825
753PhosphorylationGQCPRTVSDLALQNA
CCCCCHHHHHHHHHH		26.7130266825
803PhosphorylationPQPARLRYVTSDELL
CCCCEEEEEEHHHHH		16.8130576142
805PhosphorylationPARLRYVTSDELLHK
CCEEEEEEHHHHHHH		22.8630266825
806PhosphorylationARLRYVTSDELLHKY
CEEEEEEHHHHHHHH		21.0225849741
812UbiquitinationTSDELLHKYSSYGLP
EHHHHHHHHHHCCCC		46.96-
813PhosphorylationSDELLHKYSSYGLPK
HHHHHHHHHHCCCCC		7.66-
820UbiquitinationYSSYGLPKSSTLGGR
HHHCCCCCCCCCCCC		63.18-
841MethylationKRQKSKNCIIS----
CCCCCCCCCCC----		3.16-
841FarnesylationKRQKSKNCIIS----
CCCCCCCCCCC----		3.1617411337
841FarnesylationKRQKSKNCIIS----
CCCCCCCCCCC----		3.1617411337
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PRIC2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PRIC2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PRIC2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
A4_HUMANAPPphysical
21832049
TANC1_RATTanc1physical
25763846
RL23_RATRpl23physical
25763846
RL4_RATRpl4physical
25763846
RS26_RATRps26physical
25763846
TBB4B_RATTubb4bphysical
25763846
TBB5_RATTubb5physical
25763846
USP9X_HUMANUSP9Xphysical
25763846
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
613832Epilepsy, progressive myoclonic 5 (EPM5)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PRIC2_HUMAN

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Related Literatures of Post-Translational Modification
Prenylation
ReferencePubMed
"Towards complete sets of farnesylated and geranylgeranylatedproteins.";
Maurer-Stroh S., Koranda M., Benetka W., Schneider G., Sirota F.L.,Eisenhaber F.;
PLoS Comput. Biol. 3:634-648(2007).
Cited for: ISOPRENYLATION AT CYS-841.

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