PPIC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PPIC_HUMAN
• UniProt AC: P45877
• Protein Name: Peptidyl-prolyl cis-trans isomerase C {ECO:0000305}
• Gene Name: PPIC {ECO:0000312|HGNC:HGNC:9256}
• Organism: Homo sapiens (Human).
• Sequence Length: 212
• Subcellular Localization: Cytoplasm .
• Protein Description: PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding..
• Protein Sequence: MGPGPRLLLPLVLCVGLGALVFSSGAEGFRKRGPSVTAKVFFDVRIGDKDVGRIVIGLFGKVVPKTVENFVALATGEKGYGYKGSKFHRVIKDFMIQGGDITTGDGTGGVSIYGETFPDENFKLKHYGIGWVSMANAGPDTNGSQFFITLTKPTWLDGKHVVFGKVIDGMTVVHSIELQATDGHDRPLTNCSIINSGKIDVKTPFVVEIADW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
35	Phosphorylation	GFRKRGPSVTAKVFF CHHHCCCCEEEEEEE	34.62	20068231
37	Phosphorylation	RKRGPSVTAKVFFDV HHCCCCEEEEEEEEE	25.71	20068231
45	Methylation	AKVFFDVRIGDKDVG EEEEEEEEECCCCHH	29.08	115488317
65	Ubiquitination	LFGKVVPKTVENFVA ECCCCCCHHHHHHHH	54.30	29967540
78	Ubiquitination	VALATGEKGYGYKGS HHHHCCCCCCCCCCC	59.79	29967540
86	Ubiquitination	GYGYKGSKFHRVIKD CCCCCCCHHHHEEEC	54.58	23000965
92	Ubiquitination	SKFHRVIKDFMIQGG CHHHHEEECCEEECC	41.90	23000965
102	Phosphorylation	MIQGGDITTGDGTGG EEECCCCCCCCCCCC	29.48	23532336
103	Phosphorylation	IQGGDITTGDGTGGV EECCCCCCCCCCCCE	33.34	23532336
123	Methylation	TFPDENFKLKHYGIG CCCCCCCEECEEEEE	69.11	-
123	Ubiquitination	TFPDENFKLKHYGIG CCCCCCCEECEEEEE	69.11	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PPIC_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PPIC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PPIC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TMED4_HUMAN	TMED4	physical	22939629
SGTA_HUMAN	SGTA	physical	25416956
UBQL1_HUMAN	UBQLN1	physical	25416956
UBAP1_HUMAN	UBAP1	physical	25416956
BANP_HUMAN	BANP	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00172: L-Proline