dbPTM

PP14A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PP14A_HUMAN
UniProt AC	Q96A00
Protein Name	Protein phosphatase 1 regulatory subunit 14A
Gene Name	PPP1R14A
Organism	Homo sapiens (Human).
Sequence Length	147
Subcellular Localization	Cytoplasm.
Protein Description	Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction..
Protein Sequence	MAAQRLGKRVLSKLQSPSRARGPGGSPGGLQKRHARVTVKYDRRELQRRLDVEKWIDGRLEELYRGMEADMPDEINIDELLELESEEERSRKIQGLLKSCGKPVEDFIQELLAKLQGLHRQPGLRQPSPSHDGSLSPLQDRARTAHP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Methylation	---MAAQRLGKRVLS ---CHHHHHHHHHHH	40.45	115488467
12	Phosphorylation	RLGKRVLSKLQSPSR HHHHHHHHHCCCCCC	28.59	11287002
16	Phosphorylation	RVLSKLQSPSRARGP HHHHHCCCCCCCCCC	34.97	27422710
18	Phosphorylation	LSKLQSPSRARGPGG HHHCCCCCCCCCCCC	43.76	26434776
19	Methylation	SKLQSPSRARGPGGS HHCCCCCCCCCCCCC	31.52	115488477
21	Methylation	LQSPSRARGPGGSPG CCCCCCCCCCCCCCC	51.21	16287989
26	Phosphorylation	RARGPGGSPGGLQKR CCCCCCCCCCCCCHH	26.70	23401153
32	Methylation	GSPGGLQKRHARVTV CCCCCCCHHCCEEEE	51.71	116253377
32	Ubiquitination	GSPGGLQKRHARVTV CCCCCCCHHCCEEEE	51.71	32142685
38	Phosphorylation	QKRHARVTVKYDRRE CHHCCEEEEEECHHH	13.01	18835557
40	Methylation	RHARVTVKYDRRELQ HCCEEEEEECHHHHH	31.87	72605009
40	Ubiquitination	RHARVTVKYDRRELQ HCCEEEEEECHHHHH	31.87	33845483
64 (in isoform 2)	Phosphorylation	-	14.38	20068231
101	Phosphorylation	QGLLKSCGKPVEDFI HHHHHHCCCCHHHHH	44.38	32142685
107	Phosphorylation	CGKPVEDFIQELLAK CCCCHHHHHHHHHHH	3.82	32142685
109	Phosphorylation	KPVEDFIQELLAKLQ CCHHHHHHHHHHHHC	34.97	33259812
128	Phosphorylation	QPGLRQPSPSHDGSL CCCCCCCCCCCCCCC	30.60	23401153
130	Phosphorylation	GLRQPSPSHDGSLSP CCCCCCCCCCCCCCH	38.25	22617229
134	Phosphorylation	PSPSHDGSLSPLQDR CCCCCCCCCCHHHHH	31.56	28355574
136	Phosphorylation	PSHDGSLSPLQDRAR CCCCCCCCHHHHHHH	25.84	23401153

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
12	S	Phosphorylation	Kinase	DAPK3	O43293	PSP
38	T	Phosphorylation	Kinase	PRKCE	Q02156	GPS
38	T	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
38	T	Phosphorylation	Kinase	PKC	-	Uniprot
38	T	Phosphorylation	Kinase	PKG-FAMILY	-	GPS
38	T	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
38	T	Phosphorylation	Kinase	ROCK2	O75116	PSP
38	T	Phosphorylation	Kinase	PKD1	P98161	PhosphoELM
38	T	Phosphorylation	Kinase	PRKCZ	Q05513	GPS
38	T	Phosphorylation	Kinase	PRKD1	Q15139	PSP
38	T	Phosphorylation	Kinase	PRKCD	Q05655	GPS
38	T	Phosphorylation	Kinase	PRKCA	P17252	GPS
38	T	Phosphorylation	Kinase	PRKG1	Q13976	GPS
38	T	Phosphorylation	Kinase	PRKACA	P17612	GPS
38	T	Phosphorylation	Kinase	ILK	Q13418	PSP
38	T	Phosphorylation	Kinase	DAPK3	O43293	PSP
130	S	Phosphorylation	Kinase	CAMK2-FAMILY	-	GPS
130	S	Phosphorylation	Kinase	KCC2A	Q9UQM7	PhosphoELM

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PP14A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PP14A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
KPCA_HUMAN	PRKCA	physical	15003508
KPCE_HUMAN	PRKCE	physical	15003508
KPCL_HUMAN	PRKCH	physical	15003508
KPCZ_HUMAN	PRKCZ	physical	15003508
KPCD1_HUMAN	PRKD1	physical	15003508
KC1A_HUMAN	CSNK1A1	physical	15003508
KC1E_HUMAN	CSNK1E	physical	15003508
1433Z_HUMAN	YWHAZ	physical	15003508
KC1D_HUMAN	CSNK1D	physical	15003508
KC1G1_HUMAN	CSNK1G1	physical	15003508
KC1G2_HUMAN	CSNK1G2	physical	15003508
KC1G3_HUMAN	CSNK1G3	physical	15003508

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PP14A_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26; SER-128; SER-134 ANDSER-136, AND MASS SPECTROMETRY.	19413330 [Abstract]
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26; SER-128 AND SER-136,AND MASS SPECTROMETRY.	18088087 [Abstract]