PODO_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PODO_HUMAN
• UniProt AC: Q9NP85
• Protein Name: Podocin
• Gene Name: NPHS2
• Organism: Homo sapiens (Human).
• Sequence Length: 383
• Subcellular Localization: Isoform 1: Cell membrane ; Peripheral membrane protein .; Isoform 2: Endoplasmic reticulum .
• Protein Description: Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton..
• Protein Sequence: MERRARSSSRESRGRGGRTPHKENKRAKAERSGGGRGRQEAGPEPSGSGRAGTPGEPRAPAATVVDVDEVRGSGEEGTEVVALLESERPEEGTKSSGLGACEWLLVLISLLFIIMTFPFSIWFCVKVVQEYERVIIFRLGHLLPGRAKGPGLFFFLPCLDTYHKVDLRLQTLEIPFHEIVTKDMFIMEIDAICYYRMENASLLLSSLAHVSKAVQFLVQTTMKRLLAHRSLTEILLERKSIAQDAKVALDSVTCIWGIKVERIEIKDVRLPAGLQHSLAVEAEAQRQAKVRMIAAEAEKAASESLRMAAEILSGTPAAVQLRYLHTLQSLSTEKPSTVVLPLPFDLLNCLSSPSNRTQGSLPFPSPSKPVEPLNPKKKDSPML

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MERRARSSSRESRGR CCCCHHCCCCHHCCC	28.06	24719451
9	Phosphorylation	ERRARSSSRESRGRG CCCHHCCCCHHCCCC	41.11	24719451
53	Phosphorylation	SGSGRAGTPGEPRAP CCCCCCCCCCCCCCC	27.43	28857561
63	Phosphorylation	EPRAPAATVVDVDEV CCCCCCCEEEEHHHC	24.14	28857561
73	Phosphorylation	DVDEVRGSGEEGTEV EHHHCCCCCCCCCEE	32.25	28857561
78	Phosphorylation	RGSGEEGTEVVALLE CCCCCCCCEEEEEEE	28.96	28857561
86	Phosphorylation	EVVALLESERPEEGT EEEEEEECCCCCCCC	38.58	28857561
101	S-palmitoylation	KSSGLGACEWLLVLI CCCCHHHHHHHHHHH	3.51	-
194	Phosphorylation	MEIDAICYYRMENAS HHHCHHHEHHCCCHH	6.49	22817900
195	Phosphorylation	EIDAICYYRMENASL HHCHHHEHHCCCHHH	10.08	22817900
211	Phosphorylation	LSSLAHVSKAVQFLV HHHHHHHHHHHHHHH	12.67	22210691
277	Phosphorylation	LPAGLQHSLAVEAEA CCCCCCHHHHHHHHH	12.69	-
287 (in isoform 2)	N-linked_Glycosylation	-	33.19	23648087
302	Phosphorylation	AEAEKAASESLRMAA HHHHHHHHHHHHHHH	32.36	24719451
313	Phosphorylation	RMAAEILSGTPAAVQ HHHHHHHCCCCHHHH	46.40	-
355	N-linked_Glycosylation	NCLSSPSNRTQGSLP HHHCCCCCCCCCCCC	55.17	23648087
360	Phosphorylation	PSNRTQGSLPFPSPS CCCCCCCCCCCCCCC	24.05	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PODO_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PODO_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PODO_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NPHN_MOUSE	Nphs1	physical	12424224
PODO_MOUSE	Nphs2	physical	12424224
NPHN_HUMAN	NPHS1	physical	11733557
CD2AP_HUMAN	CD2AP	physical	11733557
SH3K1_HUMAN	SH3KBP1	physical	20457601
CD2AP_HUMAN	CD2AP	physical	20457601

Drug and Disease Associations

• Kegg Disease
• H00626: Nephrotic syndrome and focal segmental glomerulosclerosis
• OMIM Disease
• 600995: Nephrotic syndrome 2 (NPHS2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.