dbPTM

PLP1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PLP1_SCHPO
UniProt AC	O14095
Protein Name	Thioredoxin domain-containing protein plp1
Gene Name	plp1
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	279
Subcellular Localization	Cytoplasm . Nucleus .
Protein Description	Inhibits early G-protein signaling events following pheromone stimulation. May help create heterodimerizable beta-tubulin by facilitating the efficient transfer of nascent beta-tubulin polypeptides to the folding apparatus (By similarity)..
Protein Sequence	MTSFPASHGFGPRKRGYQMDLTNVQPVENKPAWISMKSPLEKEIANEYEALKVTERKEDTQDYNEPELHNSNDPTVDLYADTYATQAATESDSELEDALFSQLDEFDDTAYREQRLEMLKKEFARVEAAKEKGHMQFLTVENEREVMDFTLSSKKVVIHFYHPDFIRCKIIDSHLEKIAKVHWETKFIRIEAANAPFLVVKLGLKVLPAVLCYVNSQLVDKIIGFADLGNKDDFETSLLEFRLLKSSAIDRLKEESSSNKSIYHDELQNNQSDDSDFFE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
35	Phosphorylation	ENKPAWISMKSPLEK CCCCEEEECCCHHHH	24763107
38	Phosphorylation	PAWISMKSPLEKEIA CEEEECCCHHHHHHH	24763107
261	Phosphorylation	EESSSNKSIYHDELQ HHCCCCCCHHHHHHH	21712547
272	Phosphorylation	DELQNNQSDDSDFFE HHHHCCCCCCCCCCC	28889911
275	Phosphorylation	QNNQSDDSDFFE--- HCCCCCCCCCCC---	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PLP1_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PLP1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PLP1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PAT1_SCHPO	SPBC19G7.10c	physical	26771498
LSM5_SCHPO	lsm5	physical	26771498
LSM3_SCHPO	lsm3	physical	26771498
LSM2_SCHPO	lsm2	physical	26771498
LSM8_SCHPO	lsm8	physical	26771498

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PLP1_SCHPO

Related Literatures of Post-Translational Modification