dbPTM

PHF2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PHF2_SCHPO
UniProt AC	Q09908
Protein Name	SWM histone demethylase complex subunit phf2
Gene Name	phf2
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	538
Subcellular Localization	Nucleus .
Protein Description	Component of the SWM histone demethylase complex that specifically demethylates H3K9me2, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Has a role in regulating heterochromatin propagation and euchromatic transcription..
Protein Sequence	MPNSSYYDDDGGSFEAASYPFQFDGSRRFPNDLHPTMFEGEESNQNGGSVLIDQAFQDIQNPNVNSNMHLENQFQHFHEPNKESGAFGSYKNDDVAKEIESSKNQETDAKSEQAPFTEDASSSNYAHHRSADSQTKSALPPNVPASSSPLPPMSIAMNIARKRSWPASLAIERDNTADALFSTEDGREEQFNLEGVKTKSGRKVHRPNHFDPLVKLPTRRRGPGRRPVVALAMKCSVCQRLQSPPKNRIVFCDGCNTPFHQLCHEPYISDELLDSPNGEWFCDDCIRRKKQAPLVTGTTARELNLSSEEKKSYLLSLPISQLVDILLFCEQLHPDIPFYSPKTSTIVQELQSKRSAFTATMNEPVTGDQYLSLNNGTESQSKTTKHSTSLPSTEPVEVDKQYMESEKIPTIDEYLQEYSNEDEIVLQVLESFPAAVSFSTITNTIQAKYSNRKIKNSNITRSLNRLVRKNRVLRDARGSSYELNRTFDADRPSVRPDISITGPIPIDWMLYTPHTEDLTENFCTYYMFDETPIVLSSI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
111	Phosphorylation	NQETDAKSEQAPFTE CCCCCHHHCCCCCCC	36.34	29996109

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PHF2_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PHF2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PHF2_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
YIDH_SCHPO	SPAC227.17c	genetic	22681890
PDS5_SCHPO	pds5	genetic	22681890
MCL1_SCHPO	mcl1	genetic	22681890
ATP11_SCHPO	atp11	physical	26771498
YF75_SCHPO	spa2	physical	26771498
MEU26_SCHPO	meu26	physical	26771498
DPH3_SCHPO	dph3	physical	26771498
RAN1_SCHPO	ran1	physical	26771498
CLF1_SCHPO	cwf4	physical	26771498
AP1M1_SCHPO	apm1	physical	26771498

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PHF2_SCHPO

Related Literatures of Post-Translational Modification