PCFS4_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PCFS4_ARATH
• UniProt AC: Q0WPF2
• Protein Name: Polyadenylation and cleavage factor homolog 4 {ECO:0000305}
• Gene Name: PCFS4 {ECO:0000303|PubMed:18479511}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 808
• Subcellular Localization: Nucleus . Cytoplasm .
• Protein Description: Promotes flowering by suppressing FLC-mediated inhibition of flowering through the regulation of FCA pre-mRNA alternative processing. [PubMed: 18298670 Regulates mRNA maturation including alternative polyadenylation, splicing or transcription initiation of stress-associated genes]
• Protein Sequence: MDSEKILNPRLVSINSTSRKGMSVELPQKPPPPPSLLDRFKALLNQREDEFGGGEEVLPPSMDEIVQLYEVVLGELTFNSKPIITDLTIIAGEQREHGEGIANAICTRILEAPVEQKLPSLYLLDSIVKNIGRDYGRYFSSRLPEVFCLAYRQAHPSLHPSMRHLFGTWSSVFPPPVLRKIDMQLQLSSAANQSSVGASEPSQPTRGIHVNPKYLRRLEPSAAENNLRGINSSARVYGQNSLGGYNDFEDQLESPSSLSSTPDGFTRRSNDGANPSNQAFNYGMGRATSRDDEHMEWRRKENLGQGNDHERPRALIDAYGVDTSKHVTINKPIRDMNGMHSKMVTPWQNTEEEEFDWEDMSPTLDRSRAGEFLRSSVPALGSVRARPRVGNTSDFHLDSDIKNGVSHQLRENWSLSQNYPHTSNRVDTRAGKDLKVLASSVGLVSSNSEFGAPPFDSIQDVNSRFGRALPDGTWPHLSARGPNSLPVPSAHLHHLANPGNAMSNRLQGKPLYRPENQVSQSHLNDMTQQNQMLVNYLPSSSAMAPRPMQSLLTHVSHGYPPHGSTIRPSLSIQGGEAMHPLSSGVLSQIGASNQPPGGAFSGLIGSLMAQGLISLNNQPAGQGPLGLEFDADMLKIRNESAISALYGDLPRQCTTCGLRFKCQEEHSKHMDWHVTKNRMSKNHKQNPSRKWFVSASMWLSGAEALGAEAVPGFLPTEPTTEKKDDEDMAVPADEDQTSCALCGEPFEDFYSDETEEWMYKGAVYMNAPEESTTDMDKSQLGPIVHAKCRPESNGGDMEEGSQRKKMRS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
237	Phosphorylation	INSSARVYGQNSLGG CCCCCEEECCCCCCC		23172892
241	Phosphorylation	ARVYGQNSLGGYNDF CEEECCCCCCCCCCH		23172892
245	Phosphorylation	GQNSLGGYNDFEDQL CCCCCCCCCCHHHHH		23172892
254	Phosphorylation	DFEDQLESPSSLSST CHHHHHCCCCCCCCC		23172892
256	Phosphorylation	EDQLESPSSLSSTPD HHHHCCCCCCCCCCC		23172892
257	Phosphorylation	DQLESPSSLSSTPDG HHHCCCCCCCCCCCC		23172892
259	Phosphorylation	LESPSSLSSTPDGFT HCCCCCCCCCCCCCC		23172892
260	Phosphorylation	ESPSSLSSTPDGFTR CCCCCCCCCCCCCCC		23172892
261	Phosphorylation	SPSSLSSTPDGFTRR CCCCCCCCCCCCCCC		23172892
266	Phosphorylation	SSTPDGFTRRSNDGA CCCCCCCCCCCCCCC		23172892

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PCFS4_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PCFS4_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PCFS4_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CLP1_ARATH	CLPS3	physical	18298670
FY_ARATH	FY	physical	18298670
RPB8B_ARATH	NRPB8B	physical	24004414
PCFS1_ARATH	AT1G66500	physical	18479511
PCFS4_ARATH	PCFS4	physical	18479511

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.