PARP6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PARP6_HUMAN
• UniProt AC: Q2NL67
• Protein Name: Poly [ADP-ribose] polymerase 6
• Gene Name: PARP6
• Organism: Homo sapiens (Human).
• Sequence Length: 630
• Protein Sequence: MDIKGQFWNDDDSEGDNESEEFLYGVQGSCAADLYRHPQLDADIEAVKEIYSENSVSIREYGTIDDVDIDLHINISFLDEEVSTAWKVLRTEPIVLRLRFSLSQYLDGPEPSIEVFQPSNKEGFGLGLQLKKILGMFTSQQWKHLSNDFLKTQQEKRHSWFKASGTIKKFRAGLSIFSPIPKSPSFPIIQDSMLKGKLGVPELRVGRLMNRSISCTMKNPKVEVFGYPPSPQAGLLCPQHVGLPPPARTSPLVSGHCKNIPTLEYGFLVQIMKYAEQRIPTLNEYCVVCDEQHVFQNGSMLKPAVCTRELCVFSFYTLGVMSGAAEEVATGAEVVDLLVAMCRAALESPRKSIIFEPYPSVVDPTDPKTLAFNPKKKNYERLQKALDSVMSIREMTQGSYLEIKKQMDKLDPLAHPLLQWIISSNRSHIVKLPLSRLKFMHTSHQFLLLSSPPAKEARFRTAKKLYGSTFAFHGSHIENWHSILRNGLVNASYTKLQLHGAAYGKGIYLSPISSISFGYSGMGKGQHRMPSKDELVQRYNRMNTIPQTRSIQSRFLQSRNLNCIALCEVITSKDLQKHGNIWVCPVSDHVCTRFFFVYEDGQVGDANINTQDPKIQKEIMRVIGTQVYTN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
55	Phosphorylation	KEIYSENSVSIREYG HHHHHCCCCEEEECC	17.12	24719451
57	Phosphorylation	IYSENSVSIREYGTI HHHCCCCEEEECCCC	18.75	24719451
101	Phosphorylation	IVLRLRFSLSQYLDG EEEEEEEEHHHHCCC	22.22	-
103	Phosphorylation	LRLRFSLSQYLDGPE EEEEEEHHHHCCCCC	18.64	-
105	Phosphorylation	LRFSLSQYLDGPEPS EEEEHHHHCCCCCCC	11.91	-
175	Phosphorylation	KKFRAGLSIFSPIPK HHHCCCCEEECCCCC	22.22	24702127
178	Phosphorylation	RAGLSIFSPIPKSPS CCCCEEECCCCCCCC	21.90	24702127
237	ADP-ribosylation	SPQAGLLCPQHVGLP CCCCCCCCCCCCCCC	3.52	25043379
348	Phosphorylation	MCRAALESPRKSIIF HHHHHHHCCCCCEEE	30.75	23879269
352	Phosphorylation	ALESPRKSIIFEPYP HHHCCCCCEEEECCC	23.38	-
384	Ubiquitination	KNYERLQKALDSVMS CCHHHHHHHHHHHHH	56.35	-
388	Phosphorylation	RLQKALDSVMSIREM HHHHHHHHHHHHHHH	22.14	-
391	Phosphorylation	KALDSVMSIREMTQG HHHHHHHHHHHHHCC	19.15	23532336
404	Ubiquitination	QGSYLEIKKQMDKLD CCCHHHHHHHHHHCC	27.81	-
442	Phosphorylation	SRLKFMHTSHQFLLL HHHCCCCCCCEEEHH	19.00	29083192
443	Phosphorylation	RLKFMHTSHQFLLLS HHCCCCCCCEEEHHC	10.70	29083192
482	Phosphorylation	SHIENWHSILRNGLV HHHHHHHHHHHCCCC	18.22	-
544	Phosphorylation	QRYNRMNTIPQTRSI HHHHHCCCCCCHHHH	25.37	30242111
548	Phosphorylation	RMNTIPQTRSIQSRF HCCCCCCHHHHHHHH	22.49	30242111
600	ADP-ribosylation	RFFFVYEDGQVGDAN EEEEEEECCEECCCC	34.83	25043379

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PARP6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PARP6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PARP6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ANKY2_HUMAN	ANKMY2	physical	22863883
ARI2_HUMAN	ARIH2	physical	22863883
NSF1C_HUMAN	NSFL1C	physical	22863883
PLIN3_HUMAN	PLIN3	physical	22863883
RPR1A_HUMAN	RPRD1A	physical	22863883
SURF2_HUMAN	SURF2	physical	22863883

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.