OBE2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OBE2_ARATH
• UniProt AC: Q9LUB7
• Protein Name: Protein OBERON 2
• Gene Name: OBE2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 574
• Subcellular Localization: Nucleus .
• Protein Description: Together with OBE1, required for the maintenance and/or establishment of both the shoot and root meristems, probably by controlling the expression of the meristem genes such as WUS, PLT1 and PLT2 and of genes required for auxin responses. Promotes cell meristematic activity via the WUSCHEL-CLAVATA pathway. Involved in the development of the basal pole and in auxin-mediated root and vascular development in the embryo. Confers sensitivity to turnip mosaic virus (TuMV) probably by promoting viral movement and multiplication via interaction with TuMV VPg..
• Protein Sequence: MGTSSGSNHPHQMLPPRQQQRSGGGLETALSLVSSDQEPRRESPAESASSQETWPLGDTVAGKKSMSQKTEPDSMEQTVNVMHHVSNADKVSVRDIARERVELVAERMHRLPDEFLDELKNGLKSILEGNVAQSVDEFMFLQKVVQSRTDLSSVTLVRAHRVQLEILVAINTGIQAFLHPNISLSQPSLIEIFVYKRCRNIACQNQLPADDCYCDICTNRKGFCNLCMCTICNKFDFSVNTCRWIGCDLCSHWTHTDCAIRDGQITTGSSAKNNTSGPGEIVFKCRACNRTSELLGWVKDVFQHCAPNWDRESLMKELDFVSRIFRGSEDQRGRKLFWKCEELIDKIKGGLAEATAAKLILMFFQEIESDSAKSFENGEGGRLMAPQDACNRIAEVVQETLRKMEIVAEEKMRMFKKARMALETCDRELEDKAKEVSELKAERQKKKLQIDELERIVRLKQAEADMFQLKANEAKREADRLQRIVLAKMDKSEEEYASNYLKQRLSEAEAEKQYLFEKIKLQENSRVASQSSGGGGDPSQVMMYSKIRDLLQGYNLSPKVDPQLNERNPFRSNP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MGTSSGSNHP -----CCCCCCCCCC	20.58	25561503
4	Phosphorylation	----MGTSSGSNHPH ----CCCCCCCCCCC	27.29	25561503
5	Phosphorylation	---MGTSSGSNHPHQ ---CCCCCCCCCCCC	46.18	25561503
22	Phosphorylation	PPRQQQRSGGGLETA CHHHHCCCCCCHHHH	37.14	23111157
28	Phosphorylation	RSGGGLETALSLVSS CCCCCHHHHHHHHCC	37.63	19880383
31	Phosphorylation	GGLETALSLVSSDQE CCHHHHHHHHCCCCC	25.02	30407730
34	Phosphorylation	ETALSLVSSDQEPRR HHHHHHHCCCCCCCC	33.23	30407730
35	Phosphorylation	TALSLVSSDQEPRRE HHHHHHCCCCCCCCC	35.51	23111157
43	Phosphorylation	DQEPRRESPAESASS CCCCCCCCCCCCCCC	27.83	30407730
47	Phosphorylation	RRESPAESASSQETW CCCCCCCCCCCCCCC	35.24	30407730
49	Phosphorylation	ESPAESASSQETWPL CCCCCCCCCCCCCCC	41.66	30407730
50	Phosphorylation	SPAESASSQETWPLG CCCCCCCCCCCCCCC	31.58	30407730
53	Phosphorylation	ESASSQETWPLGDTV CCCCCCCCCCCCCCC	25.42	30407730
554	Phosphorylation	IRDLLQGYNLSPKVD HHHHHCCCCCCCCCC	10.44	25561503
557	Phosphorylation	LLQGYNLSPKVDPQL HHCCCCCCCCCCCCH	21.02	30407730

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of OBE2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OBE2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OBE2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
OBE1_ARATH	OBE1	physical	22378640
OBE2_ARATH	OBE2	physical	22378640
OBE4_ARATH	AT3G63500	physical	22378640
OBE3_ARATH	AT1G14740	physical	22378640

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.