NYAP1_HUMAN - dbPTM
NYAP1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NYAP1_HUMAN
UniProt AC Q6ZVC0
Protein Name Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1
Gene Name NYAP1
Organism Homo sapiens (Human).
Sequence Length 841
Subcellular Localization
Protein Description Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis..
Protein Sequence MNLLYRKTKLEWRQHKEEEAKRSSSKEVAPAGSAGPAAGQGPGVRVRDIASLRRSLRMGFMTMPASQEHTPHPCRSAMAPRSLSCHSVGSMDSVGGGPGGASGGLTEDSSTRRPPAKPRRHPSTKLSMVGPGSGAETPPSKKAGSQKPTPEGRESSRKVPPQKPRRSPNTQLSVSFDESCPPGPSPRGGNLPLQRLTRGSRVAGDPDVGAQEEPVYIEMVGDVFRGGGRSGGGLAGPPLGGGGPTPPAGADSDSEESEAIYEEMKYPLPEEAGEGRANGPPPLTATSPPQQPHALPPHAHRRPASALPSRRDGTPTKTTPCEIPPPFPNLLQHRPPLLAFPQAKSASRTPGDGVSRLPVLCHSKEPAGSTPAPQVPARERETPPPPPPPPAANLLLLGPSGRARSHSTPLPPQGSGQPRGERELPNSHSMICPKAAGAPAAPPAPAALLPGPPKDKAVSYTMVYSAVKVTTHSVLPAGPPLGAGEPKTEKEISVLHGMLCTSSRPPVPGKTSPHGGAMGAAAGVLHHRGCLASPHSLPDPTVGPLTPLWTYPATAAGLKRPPAYESLKAGGVLNKGCGVGAPSPMVKIQLQEQGTDGGAFASISCAHVIASAGTPEEEEEEVGAATFGAGWALQRKVLYGGRKAKELDKVEDGARAWNGSAEGPGKVEREDRGPGTSGIPVRSQGAEGLLARIHHGDRGGSRTALPIPCQTFPACHRNGDFTGGYRLGRSASTSGVRQVVLHTPRPCSQPRDALSQPHPALPLPLPLPPQPARERDGKLLEVIERKRCVCKEIKARHRPDRGLCKQESMPILPSWRRGPEPRKSGTPPCRRQHTVLWDTAI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
23PhosphorylationKEEEAKRSSSKEVAP
HHHHHHHHCCCCCCC		37.9525278378
24PhosphorylationEEEAKRSSSKEVAPA
HHHHHHHCCCCCCCC		49.8425278378
25PhosphorylationEEAKRSSSKEVAPAG
HHHHHHCCCCCCCCC		33.8025278378
33PhosphorylationKEVAPAGSAGPAAGQ
CCCCCCCCCCCCCCC		31.9625278378
51PhosphorylationVRVRDIASLRRSLRM
CCHHHHHHHHHHHHH		23.8124719451
123PhosphorylationAKPRRHPSTKLSMVG
CCCCCCCCCCCEEEC		31.8629083192
124PhosphorylationKPRRHPSTKLSMVGP
CCCCCCCCCCEEECC		40.2229083192
127PhosphorylationRHPSTKLSMVGPGSG
CCCCCCCEEECCCCC		16.9924114839
133PhosphorylationLSMVGPGSGAETPPS
CEEECCCCCCCCCCC		37.6524114839
137PhosphorylationGPGSGAETPPSKKAG
CCCCCCCCCCCCCCC		39.7129083192
140PhosphorylationSGAETPPSKKAGSQK
CCCCCCCCCCCCCCC		48.2529083192
170PhosphorylationKPRRSPNTQLSVSFD
CCCCCCCCCEEEEEC		33.9830576142
173PhosphorylationRSPNTQLSVSFDESC
CCCCCCEEEEECCCC		13.0930576142
179PhosphorylationLSVSFDESCPPGPSP
EEEEECCCCCCCCCC		33.4930576142
254PhosphorylationPAGADSDSEESEAIY
CCCCCCCCHHHHHHH		47.41-
305PhosphorylationHAHRRPASALPSRRD
CCCCCCHHHCCCCCC		32.7824114839
345PhosphorylationLAFPQAKSASRTPGD
ECCCCCCCCCCCCCC		34.2022210691
347PhosphorylationFPQAKSASRTPGDGV
CCCCCCCCCCCCCCC		43.7222210691
349PhosphorylationQAKSASRTPGDGVSR
CCCCCCCCCCCCCCC		29.1822210691
355PhosphorylationRTPGDGVSRLPVLCH
CCCCCCCCCCCEEEE		33.36-
382PhosphorylationVPARERETPPPPPPP
CCCCCCCCCCCCCCC		47.5224076635
427PhosphorylationGERELPNSHSMICPK
CCCCCCCCCCCCCCH		18.2625690035
429PhosphorylationRELPNSHSMICPKAA
CCCCCCCCCCCCHHC		15.0625690035
459PhosphorylationPPKDKAVSYTMVYSA
CCCCCCCEEEEEEEE		21.5325072903
460PhosphorylationPKDKAVSYTMVYSAV
CCCCCCEEEEEEEEE		7.7025884760
461PhosphorylationKDKAVSYTMVYSAVK
CCCCCEEEEEEEEEE		7.8325072903
464PhosphorylationAVSYTMVYSAVKVTT
CCEEEEEEEEEEEEE		4.7025072903
465PhosphorylationVSYTMVYSAVKVTTH
CEEEEEEEEEEEEEC		18.3825072903
533PhosphorylationHHRGCLASPHSLPDP
HHCCCCCCCCCCCCC		15.36-
551PhosphorylationPLTPLWTYPATAAGL
CCCCCCCCCCCCCCC		4.54-
554PhosphorylationPLWTYPATAAGLKRP
CCCCCCCCCCCCCCC		16.73-
639PhosphorylationALQRKVLYGGRKAKE
HHHHHHHHCCCCCHH		22.1118083107
649AcetylationRKAKELDKVEDGARA
CCCHHHCCCCCCCCC		61.2119825487
666AcetylationGSAEGPGKVEREDRG
CCCCCCCCCCCCCCC		44.0219821401
703PhosphorylationGDRGGSRTALPIPCQ
CCCCCCCCCCCCCCC		33.95-
743PhosphorylationVRQVVLHTPRPCSQP
CEEEEECCCCCCCCC		19.48-
805AcetylationRPDRGLCKQESMPIL
CCCCCCCCCCCCCCC		63.2412655481
814PhosphorylationESMPILPSWRRGPEP
CCCCCCCHHCCCCCC		29.7526091039
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NYAP1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NYAP1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NYAP1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NCKP1_HUMANNCKAP1physical
21946561
CYFP2_HUMANCYFIP2physical
21946561
CYFP1_HUMANCYFIP1physical
21946561
P85A_HUMANPIK3R1physical
21946561
RHG26_HUMANARHGAP26physical
21946561
ACOT9_HUMANACOT9physical
21946561
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NYAP1_HUMAN

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Related Literatures of Post-Translational Modification

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