NUD12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NUD12_HUMAN
• UniProt AC: Q9BQG2
• Protein Name: Peroxisomal NADH pyrophosphatase NUDT12
• Gene Name: NUDT12
• Organism: Homo sapiens (Human).
• Sequence Length: 462
• Subcellular Localization: Peroxisome .
• Protein Description: Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle..
• Protein Sequence: MSSVKRSLKQEIVTQFHCSAAEGDIAKLTGILSHSPSLLNETSENGWTALMYAARNGHPEIVQFLLEKGCDRSIVNKSRQTALDIAVFWGYKHIANLLATAKGGKKPWFLTNEVEECENYFSKTLLDRKSEKRNNSDWLLAKESHPATVFILFSDLNPLVTLGGNKESFQQPEVRLCQLNYTDIKDYLAQPEKITLIFLGVELEIKDKLLNYAGEVPREEEDGLVAWFALGIDPIAAEEFKQRHENCYFLHPPMPALLQLKEKEAGVVAQARSVLAWHSRYKFCPTCGNATKIEEGGYKRLCLKEDCPSLNGVHNTSYPRVDPVVIMQVIHPDGTKCLLGRQKRFPPGMFTCLAGFIEPGETIEDAVRREVEEESGVKVGHVQYVACQPWPMPSSLMIGCLALAVSTEIKVDKNEIEDARWFTREQVLDVLTKGKQQAFFVPPSRAIAHQLIKHWIRINPNL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
84	Ubiquitination	KSRQTALDIAVFWGY HHHHHHHHHHHHHHH	25.08	32015554
91	Phosphorylation	DIAVFWGYKHIANLL HHHHHHHHHHHHHHH	7.03	26074081
100	Phosphorylation	HIANLLATAKGGKKP HHHHHHHHHCCCCCC	28.95	26074081
102	Ubiquitination	ANLLATAKGGKKPWF HHHHHHHCCCCCCEE	64.93	32015554
102	Acetylation	ANLLATAKGGKKPWF HHHHHHHCCCCCCEE	64.93	30590937
111	Phosphorylation	GKKPWFLTNEVEECE CCCCEEECCCHHHHH	21.62	26074081
136	Phosphorylation	KSEKRNNSDWLLAKE HHHHHCCCCCHHHCC	33.44	27251275
167	Ubiquitination	VTLGGNKESFQQPEV EECCCCHHHHCCCCE	61.87	29967540
181	Phosphorylation	VRLCQLNYTDIKDYL EEEECCCCCCHHHHH	17.87	-
185	Succinylation	QLNYTDIKDYLAQPE CCCCCCHHHHHCCCC	43.03	-
185	Succinylation	QLNYTDIKDYLAQPE CCCCCCHHHHHCCCC	43.03	-
185	Ubiquitination	QLNYTDIKDYLAQPE CCCCCCHHHHHCCCC	43.03	29967540
187	Phosphorylation	NYTDIKDYLAQPEKI CCCCHHHHHCCCCCE	10.03	-
261	Ubiquitination	MPALLQLKEKEAGVV CHHHHHHHHHHHHHH	54.50	-
292	Succinylation	PTCGNATKIEEGGYK CCCCCCEEEECCCEE	45.79	-
292	Succinylation	PTCGNATKIEEGGYK CCCCCCEEEECCCEE	45.79	-
415	Ubiquitination	EIKVDKNEIEDARWF CEECCHHHHCHHCCC	54.20	29967540
433	Ubiquitination	QVLDVLTKGKQQAFF HHHHHHHCCCCCEEE	61.01	29967540
453	Acetylation	AIAHQLIKHWIRINP HHHHHHHHHHHHCCC	41.29	23954790

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NUD12_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NUD12_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NUD12_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NCOA5_HUMAN	NCOA5	physical	26186194
FKB15_HUMAN	FKBP15	physical	26186194
LZTR1_HUMAN	LZTR1	physical	26186194
VWA8_HUMAN	VWA8	physical	26186194
BLMH_HUMAN	BLMH	physical	26186194
ZO2_HUMAN	TJP2	physical	26186194
SIR2_HUMAN	SIRT2	physical	26186194
LZTR1_HUMAN	LZTR1	physical	28514442
NCOA5_HUMAN	NCOA5	physical	28514442
VWA8_HUMAN	VWA8	physical	28514442
FKB15_HUMAN	FKBP15	physical	28514442
ZO2_HUMAN	TJP2	physical	28514442
SIR2_HUMAN	SIRT2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.