NKG2A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NKG2A_HUMAN
• UniProt AC: P26715
• Protein Name: NKG2-A/NKG2-B type II integral membrane protein
• Gene Name: KLRC1
• Organism: Homo sapiens (Human).
• Sequence Length: 233
• Subcellular Localization: Membrane; Single-pass type II membrane protein.
• Protein Description: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells..
• Protein Sequence: MDNQGVIYSDLNLPPNPKRQQRKPKGNKNSILATEQEITYAELNLQKASQDFQGNDKTYHCKDLPSAPEKLIVGILGIICLILMASVVTIVVIPSTLIQRHNNSSLNTRTQKARHCGHCPEEWITYSNSCYYIGKERRTWEESLLACTSKNSSLLSIDNEEEMKFLSIISPSSWIGVFRNSSHHPWVTMNGLAFKHEIKDSDNAELNCAVLQVNRLKSAQCGSSIIYHCKHKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MDNQGVIYSDLNLPP CCCCCCCCCCCCCCC	8.17	12165520
40	Phosphorylation	ATEQEITYAELNLQK ECHHHEEHHHHHHHH	12.07	12165520
89	Phosphorylation	ILMASVVTIVVIPST HHHHHCHHEEECCHH	13.10	-
102	N-linked_Glycosylation	STLIQRHNNSSLNTR HHHHHHCCCCCCCHH	52.87	UniProtKB CARBOHYD
103	N-linked_Glycosylation	TLIQRHNNSSLNTRT HHHHHCCCCCCCHHH	27.18	UniProtKB CARBOHYD
104	Phosphorylation	LIQRHNNSSLNTRTQ HHHHCCCCCCCHHHH	41.33	-
105	Phosphorylation	IQRHNNSSLNTRTQK HHHCCCCCCCHHHHH	27.97	-
108	Phosphorylation	HNNSSLNTRTQKARH CCCCCCCHHHHHHHC	40.15	-
110	Phosphorylation	NSSLNTRTQKARHCG CCCCCHHHHHHHCCC	32.17	-
151	N-linked_Glycosylation	LLACTSKNSSLLSID HHHHCCCCCCCCCCC	36.28	UniProtKB CARBOHYD
167	Phosphorylation	EEEMKFLSIISPSSW HHHHHHEEEECHHHE	22.47	30108239
170	Phosphorylation	MKFLSIISPSSWIGV HHHEEEECHHHEEEE	19.63	30108239
172	Phosphorylation	FLSIISPSSWIGVFR HEEEECHHHEEEEEC	31.36	30108239
173	Phosphorylation	LSIISPSSWIGVFRN EEEECHHHEEEEECC	26.54	30108239
180	N-linked_Glycosylation	SWIGVFRNSSHHPWV HEEEEECCCCCCCEE	36.08	UniProtKB CARBOHYD
195	Acetylation	TMNGLAFKHEIKDSD EECCEEEEEEECCCC	34.42	7479721
199	Acetylation	LAFKHEIKDSDNAEL EEEEEEECCCCCCCE	48.47	7479729

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NKG2A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NKG2A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NKG2A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KLRD1_HUMAN	KLRD1	physical	10320637
MAL_HUMAN	MAL	physical	25416956
PMP22_HUMAN	PMP22	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.