NEO1_HUMAN - dbPTM
NEO1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NEO1_HUMAN
UniProt AC Q92859
Protein Name Neogenin
Gene Name NEO1
Organism Homo sapiens (Human).
Sequence Length 1461
Subcellular Localization Cell membrane
Single-pass type I membrane protein.
Protein Description Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response..
Protein Sequence MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKMPNDQASGSGGKGSRLPDLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRTTSHQKKKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQDITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVISAHPIHSLDNPHHHFHSSSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVRNTPSTDTMPASSSQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPTYDPALPSTPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLEDSESSYEPDELTKEMAHLEGLMKDLNAITTA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
51PhosphorylationGASIRTFTPFYFLVE
CCCCCEECCEEEEEE		16.33-
68PhosphorylationDTLSVRGSSVILNCS
CEEEECCCEEEEECC		15.74-
69PhosphorylationTLSVRGSSVILNCSA
EEEECCCEEEEECCC		18.92-
73N-linked_GlycosylationRGSSVILNCSAYSEP
CCCEEEEECCCCCCC		13.43UniProtKB CARBOHYD
164PhosphorylationQPEPSSVYAGNNAIL
CCCCCCCCCCCCEEE		15.67-
210N-linked_GlycosylationSGMLVISNATEGDGG
CCCEEECCCCCCCCC		39.49UniProtKB CARBOHYD
210N-linked_GlycosylationSGMLVISNATEGDGG
CCCEEECCCCCCCCC		39.4916335952
219PhosphorylationTEGDGGLYRCVVESG
CCCCCCEEEEEEECC		12.77-
225PhosphorylationLYRCVVESGGPPKYS
EEEEEEECCCCCCCC		37.12-
326N-linked_GlycosylationFCIADNGNETIEAQA
EEEEECCCCEEEEEE		49.87UniProtKB CARBOHYD
434O-linked_GlycosylationILEHAPATTGPLPSA
EEECCCCCCCCCCCC		31.09OGP
470N-linked_GlycosylationASDPHGDNLTYSVFY
CCCCCCCCEEEEEEE		38.5819349973
470N-linked_GlycosylationASDPHGDNLTYSVFY
CCCCCCCCEEEEEEE		38.5819349973
489N-linked_GlycosylationIARERVENTSHPGEM
CEEEECCCCCCCCCE		43.9816335952
490PhosphorylationARERVENTSHPGEMQ
EEEECCCCCCCCCEE		18.2022210691
491PhosphorylationRERVENTSHPGEMQV
EEECCCCCCCCCEEE		38.9922210691
499PhosphorylationHPGEMQVTIQNLMPA
CCCCEEEEEEHHCEE		10.4322210691
507PhosphorylationIQNLMPATVYIFRVM
EEHHCEEEEEEEEEE		14.1522210691
521PhosphorylationMAQNKHGSGESSAPL
ECCCCCCCCCCCCCC		38.8222210691
524PhosphorylationNKHGSGESSAPLRVE
CCCCCCCCCCCCEEE		35.0122210691
525PhosphorylationKHGSGESSAPLRVET
CCCCCCCCCCCEEEC		29.6022210691
602PhosphorylationTINGLKKYTEYSFRV
EECCHHHCCEEEEEE		11.83-
603PhosphorylationINGLKKYTEYSFRVV
ECCHHHCCEEEEEEE		37.01-
639N-linked_GlycosylationVPSAAPQNLSLEVRN
CCCCCCCCEEEEEEC		30.4519349973
639N-linked_GlycosylationVPSAAPQNLSLEVRN
CCCCCCCCEEEEEEC		30.4519349973
715N-linked_GlycosylationRVAALTINGTGPATD
EEEEEEECCCCCCCC		36.42UniProtKB CARBOHYD
846O-linked_GlycosylationFVINAPYTPVPDPTP
EEECCCCCCCCCCCC		19.42OGP
891PhosphorylationKITDSRYYTVRWKTN
CCCCCCCEEEEEECC		9.5422817900
909N-linked_GlycosylationNTKYKNANATTLSYL
CCCCCCCCCCHHHHH		47.41UniProtKB CARBOHYD
911PhosphorylationKYKNANATTLSYLVT
CCCCCCCCHHHHHHH		28.2524719451
914PhosphorylationNANATTLSYLVTGLK
CCCCCHHHHHHHCCC		17.8324719451
915PhosphorylationANATTLSYLVTGLKP
CCCCHHHHHHHCCCC		14.3322817900
938PhosphorylationMVTKGRRSSTWSMTA
EEECCCCCCCEEEEE		30.6625137130
939PhosphorylationVTKGRRSSTWSMTAH
EECCCCCCCEEEEEC		31.8925137130
955PhosphorylationTTFELVPTSPPKDVT
CEEEEECCCCCCCEE		46.52-
956PhosphorylationTFELVPTSPPKDVTV
EEEEECCCCCCCEEE		32.89-
1056PhosphorylationFRTPKADSSDKMPND
CCCCCCCCCCCCCCC		45.34-
1057PhosphorylationRTPKADSSDKMPNDQ
CCCCCCCCCCCCCCC		41.62-
1066PhosphorylationKMPNDQASGSGGKGS
CCCCCCCCCCCCCCC		28.05-
1068PhosphorylationPNDQASGSGGKGSRL
CCCCCCCCCCCCCCC		41.71-
1080PhosphorylationSRLPDLGSDYKPPMS
CCCCCCCCCCCCCCC		45.09-
1082PhosphorylationLPDLGSDYKPPMSGS
CCCCCCCCCCCCCCC		27.39-
1162UbiquitinationSKDVKPPDLWIHHER
CCCCCCCCCEEEEEC		64.2621890473
1173UbiquitinationHHERLELKPIDKSPD
EEECCCCCCCCCCCC		30.4721890473
1173 (in isoform 1)Ubiquitination-30.4721890473
1173UbiquitinationHHERLELKPIDKSPD
EEECCCCCCCCCCCC		30.4721890473
1173 (in isoform 2)Ubiquitination-30.4721890473
1178PhosphorylationELKPIDKSPDPNPIM
CCCCCCCCCCCCCCC		30.6830576142
1186PhosphorylationPDPNPIMTDTPIPRN
CCCCCCCCCCCCCCC		37.1230576142
1188PhosphorylationPNPIMTDTPIPRNSQ
CCCCCCCCCCCCCCC		17.6021815630
1194PhosphorylationDTPIPRNSQDITPVD
CCCCCCCCCCCCCCC		30.4330266825
1198PhosphorylationPRNSQDITPVDNSMD
CCCCCCCCCCCCCCC		26.0830266825
1203PhosphorylationDITPVDNSMDSNIHQ
CCCCCCCCCCCCHHH		21.3623927012
1206PhosphorylationPVDNSMDSNIHQRRN
CCCCCCCCCHHHHHC		29.1023927012
1214PhosphorylationNIHQRRNSYRGHESE
CHHHHHCCCCCCCCH		17.8827422710
1215PhosphorylationIHQRRNSYRGHESED
HHHHHCCCCCCCCHH		24.9430576142
1220PhosphorylationNSYRGHESEDSMSTL
CCCCCCCCHHHHHHH		40.8230576142
1223PhosphorylationRGHESEDSMSTLAGR
CCCCCHHHHHHHCCC		15.5830576142
1225PhosphorylationHESEDSMSTLAGRRG
CCCHHHHHHHCCCCC		24.9929255136
1226PhosphorylationESEDSMSTLAGRRGM
CCHHHHHHHCCCCCC		16.4025849741
1279PhosphorylationSPARSHLYHPGSPWP
CCCHHHCCCCCCCCC		10.6727642862
1283PhosphorylationSHLYHPGSPWPIGTS
HHCCCCCCCCCCCCC		28.3928122231
1289PhosphorylationGSPWPIGTSMSLSDR
CCCCCCCCCCCHHHC		23.2123927012
1290PhosphorylationSPWPIGTSMSLSDRA
CCCCCCCCCCHHHCC		10.9323927012
1292PhosphorylationWPIGTSMSLSDRANS
CCCCCCCCHHHCCCC		25.2123927012
1294PhosphorylationIGTSMSLSDRANSTE
CCCCCCHHHCCCCCH		20.1128464451
1299PhosphorylationSLSDRANSTESVRNT
CHHHCCCCCHHHCCC		32.3525849741
1300PhosphorylationLSDRANSTESVRNTP
HHHCCCCCHHHCCCC		31.8923927012
1302PhosphorylationDRANSTESVRNTPST
HCCCCCHHHCCCCCC		26.8523927012
1382PhosphorylationYDPALPSTPLLSQQA
CCCCCCCCCCCCHHH		18.93-
1386PhosphorylationLPSTPLLSQQALNHH
CCCCCCCCHHHHHHH		28.12-
1399PhosphorylationHHIHSVKTASIGTLG
HHCCEEEECCCCCCC		24.3923403867
1401PhosphorylationIHSVKTASIGTLGRS
CCEEEECCCCCCCCC		27.1223403867
1404PhosphorylationVKTASIGTLGRSRPP
EEECCCCCCCCCCCC		25.1130576142
1432PhosphorylationTTRMLEDSESSYEPD
HHCHHCCCCCCCCCH		29.9728796482
1434PhosphorylationRMLEDSESSYEPDEL
CHHCCCCCCCCCHHH		42.0228796482
1435PhosphorylationMLEDSESSYEPDELT
HHCCCCCCCCCHHHH		29.4822617229
1436PhosphorylationLEDSESSYEPDELTK
HCCCCCCCCCHHHHH		40.5420007894
1442PhosphorylationSYEPDELTKEMAHLE
CCCCHHHHHHHHHHH		23.9423186163
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NEO1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NEO1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NEO1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CAD15_MOUSECdh15physical
15520228
CADH2_MOUSECdh2physical
15520228
NET3_MOUSENtn3physical
15520228
CDON_MOUSECdonphysical
15520228
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NEO1_HUMAN

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.";
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.;
Nat. Biotechnol. 27:378-386(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-210; ASN-470 AND ASN-639,AND MASS SPECTROMETRY.
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction,hydrazide chemistry, and mass spectrometry.";
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,Moore R.J., Smith R.D.;
J. Proteome Res. 4:2070-2080(2005).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-210 AND ASN-489, AND MASSSPECTROMETRY.

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