NEK5_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NEK5_ARATH
• UniProt AC: Q0WPH8
• Protein Name: Serine/threonine-protein kinase Nek5
• Gene Name: NEK5
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 956
• Protein Description: Involved in epidermal-cell morphogenesis in hypocotyls and roots. May act on the microtubule function. May have a secondary role in trichome branching..
• Protein Sequence: MESRMDQYELMEQIGRGAFGAAILVHHKAERKKYVLKKIRLARQTERCRRSAHQEMSLIARVQHPYIVEFKEAWVEKGCYVCIVTGYCEGGDMAELMKKSNGVYFPEEKLCKWFTQLLLAVEYLHSNYVLHRDLKCSNIFLTKDQDVRLGDFGLAKTLKADDLTSSVVGTPNYMCPELLADIPYGFKSDIWSLGCCIYEMAAYRPAFKAFDMAGLISKVNRSSIGPLPPCYSPSLKALIKGMLRKNPEYRPNASEILKHPYLQPYVEQYRPTLSAASITPEKPLNSREGRRSMAESQNSNSSSEKDNFYVSDKNIRYVVPSNGNKVTETDSGFVDDEDILDHVQQSAENGNLQSVSATKPDGHGILKPVHSDQRPDVIQPRHPKTIRNIMMVLKEEKARENGSPMRSNRSRPSSVPTQKNNVETPSKIPKLGDIAHSSKTNASTPIPPSKLASDSARTPGSFPPKHHMPVIDSSPKLKPRNDRISPSPAAKHEAEEAMSVKRRQRTPPTLPRRTSLIAHQSRQLGADISNMAAKETAKLHPSVPSESETNSHQSRVHASPVSTTPEPKRTSVGSAKGMQSESSNSISSSLSMQAFELCDDASTPYIDMTEHTTPDDHRRSCHSEYSYSFPDISSEMMIRRDEHSTSMRLTEIPDSVSGVQNTIAHHQPEREQGSCPTVLKDDSPATLQSYEPNTSQHQHGDDKFTVKEFVSSVPGPAPLPLHVEPSHQVNSHSDNKTSVMSQNSALEKNNSHSHPHPVVDDVIHVIRHSSFRVGSDQPVMESVEVGVQNVDMGKLINVVRDEMEVRKGATPSESPTTRSIISEPDSRTEPRPKEPDPITNYSETKSFNSCSDSSPAETRTNSFVPEEETTPTPPVKETLDIKSFRQRAEALEGLLELSADLLEQSRLEELAIVLQPFGKNKVSPRETAIWLAKSLKGMMIEDINNNNSSGSSRNCS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
157	Phosphorylation	GDFGLAKTLKADDLT CCCCCCCEECHHHCC	28.08	24894044
223	Phosphorylation	ISKVNRSSIGPLPPC HHHCCHHHCCCCCCC	28.47	22074104
249	Phosphorylation	MLRKNPEYRPNASEI HHHHCCCCCCCHHHH	32.40	22074104
506	Phosphorylation	SVKRRQRTPPTLPRR CHHHHCCCCCCCCCH	25.86	30589143
514	Phosphorylation	PPTLPRRTSLIAHQS CCCCCCHHHHHHHHH	29.21	25561503
515	Phosphorylation	PTLPRRTSLIAHQSR CCCCCHHHHHHHHHH	18.90	25561503
521	Phosphorylation	TSLIAHQSRQLGADI HHHHHHHHHHHCCHH	16.48	19880383
559	Phosphorylation	HQSRVHASPVSTTPE CCCCCCCCCCCCCCC	15.79	23776212
562	Phosphorylation	RVHASPVSTTPEPKR CCCCCCCCCCCCCCC	29.92	23776212
563	Phosphorylation	VHASPVSTTPEPKRT CCCCCCCCCCCCCCC	46.75	23776212
564	Phosphorylation	HASPVSTTPEPKRTS CCCCCCCCCCCCCCC	20.39	23776212
571	Phosphorylation	TPEPKRTSVGSAKGM CCCCCCCCCCCCCCC	28.63	25561503
574	Phosphorylation	PKRTSVGSAKGMQSE CCCCCCCCCCCCCCC	25.34	25561503
810	Phosphorylation	MEVRKGATPSESPTT HHHHCCCCCCCCCCC	35.70	23776212
812	Phosphorylation	VRKGATPSESPTTRS HHCCCCCCCCCCCCC	46.48	23776212
814	Phosphorylation	KGATPSESPTTRSII CCCCCCCCCCCCCCC	31.70	23776212
816	Phosphorylation	ATPSESPTTRSIISE CCCCCCCCCCCCCCC	44.09	23776212
822	Phosphorylation	PTTRSIISEPDSRTE CCCCCCCCCCCCCCC	41.21	23111157

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NEK5_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NEK5_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NEK5_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NEK4_ARATH	NEK4	physical	21605211
NEK5_ARATH	NEK6	physical	21605211
NEK6_ARATH	NEK5	physical	21605211

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.