dbPTM

NEK4_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NEK4_ARATH
UniProt AC	Q8RXT4
Protein Name	Serine/threonine-protein kinase Nek4
Gene Name	NEK4
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	555
Subcellular Localization
Protein Description	May be involved in plant development processes..
Protein Sequence	MERYEVLEQIGKGSFGSALLVRHKQERKKYVLKKIRLARQSDRARRSAHQEMELISTVRNPFVVEYKDSWVEKGCYVCIVIGYCQGGDMTDTIKRACGVHFPEEKLCQWLVQLLMALDYLHSNHILHRDVKCSNIFLTKEQDIRLGDFGLAKILTSDDLTSSVVGTPSYMCPELLADIPYGSKSDIWSLGCCMYEMAAHKPPFKASDVQTLITKIHKLIMDPIPAMYSGSFRGLIKSMLRKNPELRPSANELLNHPHLQPYISMVYMKLESPRRSTFPLQFSERDATLKERRRSSFSNDRRLNPSVSDTEAGSVSSSGKASPTPMFNGRKVSEVTVGVVREEIVPQRQEEAKKQSGAARTPRVAGTSAKASTQRTVFKHELMKVSNPTERRRRVSLPLVVENPYTYESDITALCSLNSPDVSVNTPRFDKIAEFPEDIFQNQNRETASRREVARHSFSSPPCPPHGEDNSNGSITKDKCTVQKRSVSEVKQRRFDTSSYQQRAEALEGLLEFSAKLLQQERYDELGVLLKPFGAERVSSRETAIWLTKSFKEASV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	LEQIGKGSFGSALLV HHHHCCCCCCCHHHH	29.89	25561503
17	Phosphorylation	IGKGSFGSALLVRHK HCCCCCCCHHHHHCH	17.46	25561503
66	Phosphorylation	RNPFVVEYKDSWVEK CCCEEEEECHHHHHC	14.42	19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NEK4_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NEK4_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NEK4_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
NEK4_ARATH	NEK4	physical	21605211
NEK5_ARATH	NEK6	physical	21605211

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NEK4_ARATH

Related Literatures of Post-Translational Modification