NBR1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NBR1_MOUSE
• UniProt AC: P97432
• Protein Name: Next to BRCA1 gene 1 protein
• Gene Name: Nbr1
• Organism: Mus musculus (Mouse).
• Sequence Length: 988
• Subcellular Localization: Cytoplasm . Cytoplasmic vesicle, autophagosome . Lysosome . Cytoplasm, myofibril, sarcomere, M line . In cardiac muscles localizes to the sarcomeric M line (By similarity). Is targeted to lysosomes for degradation (By similarity).
• Protein Description: Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets..
• Protein Sequence: MEPQVTLNVTFKNETQSFLVSDPENTTWADVEAMVKVSFDLNTIQIKYLDEENEEISINSQGEYEEALKMANIKQGNQLQMQVHEGYHVVDEALPKNVVENQAAARTGKKPLAHYSSLVRVLGSDMKTTEEPAPEQCSSAPCDTDQPQDKPPDWFTSYLEMFREQVVKETVEKLEQRLQEKLVLQKPLLSSSPTEVSMPISEETLFLPENQFSWHIACSHCQKRIVGVRYQCSLCPSYNICEDCEAGPYTHDTNHVLLKLRRPVVISSEPFFYSKYSAPRLPAALEQVRLQKQVDKNFVKAEKQRLRAEKKQRKAEVKELKKQLKLHRKIHLWNSIHGLQSPKSPLGRPESLLQSNTLMLPLQPCAPVMPTLSAAFVDENLPDGTHLQPGTKFIKHWRMKNTGNVKWNTDTKLKFMWGNLTLASTEKKDVLVPCLKAGHVGVVSVEFIAPTLEGTYTSHWRLSHKGQQFGPRVWCSIIVDPFPSSESPDNVEGDRISSSKADDFSCEQEEAFLLAEEEIPLGEVTKQTEGTGASASQKTRRAASERELYIPSVDLLTAQDLLSFELLDINIVQELERVPHNTPVDMTPCMSPLPHDSPLIEKPGLGQIQEESEGAGFKAPPDSTVSAKRKAETPASVEETEEDLSGTQFVCETVIRSLTLDAAPDHNPPCRQRSPQRELQLYSTEGQQPLVLPGFCRKDSSLKFALPEEGPRGDEREEIVHIVEEEVVEEEEEVQDEEVQSQSSASSEDYIIILPECFDTSRPLGDSMYSSALSQPGLERGAEGEPGIESGLEPTEARERLPERESQPQEQSISDILTTSQPLDTVPLVPEVAGLPAALSRSAPCGQCESSGVDSPGVDSPATMHEVPPAPDDIRGEPRGSTGLANSRQRSCDHSRHHNGSSIAGGLVKGALSVAASAYKALFSGPPVTAQPIVSEDQTTALMAHLFEMGFCDRQLNLRLLRKHNYNILQVVTELLQVNNNDWYSHRY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
57	Phosphorylation	DEENEEISINSQGEY CCCCCEEEECCCCHH	20.99	25293948
60	Phosphorylation	NEEISINSQGEYEEA CCEEEECCCCHHHHH	37.58	25293948
110	Ubiquitination	AAARTGKKPLAHYSS HHHHHCCCCCHHHHH	46.76	-
116	Phosphorylation	KKPLAHYSSLVRVLG CCCCHHHHHHHHHHC	13.82	29472430
117	Phosphorylation	KPLAHYSSLVRVLGS CCCHHHHHHHHHHCC	24.58	24899341
173	Ubiquitination	VVKETVEKLEQRLQE HHHHHHHHHHHHHHH	53.65	-
181	Ubiquitination	LEQRLQEKLVLQKPL HHHHHHHHHHHCCCC	30.82	-
275	Ubiquitination	SEPFFYSKYSAPRLP CCCCCCCCCCCCCHH	31.67	-
276	Phosphorylation	EPFFYSKYSAPRLPA CCCCCCCCCCCCHHH	12.25	21454597
277	Phosphorylation	PFFYSKYSAPRLPAA CCCCCCCCCCCHHHH	35.22	21454597
329	Ubiquitination	KQLKLHRKIHLWNSI HHHHHHHHHHHHHHH	24.59	-
335	Phosphorylation	RKIHLWNSIHGLQSP HHHHHHHHHCCCCCC	12.36	22817900
341	Phosphorylation	NSIHGLQSPKSPLGR HHHCCCCCCCCCCCC	39.06	22817900
406	Ubiquitination	MKNTGNVKWNTDTKL ECCCCCCCCCCCCCE	38.43	-
427	Ubiquitination	LTLASTEKKDVLVPC EEEEECCCCCCCHHC	55.13	-
465	Ubiquitination	SHWRLSHKGQQFGPR CCEEECCCCCCCCCE	55.85	-
484	Phosphorylation	IIVDPFPSSESPDNV EEECCCCCCCCCCCC	47.30	23140645
485	Phosphorylation	IVDPFPSSESPDNVE EECCCCCCCCCCCCC	42.19	23140645
487	Phosphorylation	DPFPSSESPDNVEGD CCCCCCCCCCCCCCC	39.23	23140645
505	Phosphorylation	SSKADDFSCEQEEAF CCCCCCCCCHHHHHH	24.60	30352176
538	Ubiquitination	TGASASQKTRRAASE CCCCCCHHHHHHHHH	41.31	-
538	Acetylation	TGASASQKTRRAASE CCCCCCHHHHHHHHH	41.31	6565869
591	Phosphorylation	VDMTPCMSPLPHDSP CCCCCCCCCCCCCCC	29.96	25338131
597	Phosphorylation	MSPLPHDSPLIEKPG CCCCCCCCCCCCCCC	20.69	-
626	Phosphorylation	APPDSTVSAKRKAET CCCCCCCCCCCCCCC	28.32	-
633	Phosphorylation	SAKRKAETPASVEET CCCCCCCCCCCHHHC	29.08	30635358
636	Phosphorylation	RKAETPASVEETEED CCCCCCCCHHHCHHH	31.12	30635358
640	Phosphorylation	TPASVEETEEDLSGT CCCCHHHCHHHHCCC	31.04	30635358
645	Phosphorylation	EETEEDLSGTQFVCE HHCHHHHCCCHHHHH	52.71	30635358
647	Phosphorylation	TEEDLSGTQFVCETV CHHHHCCCHHHHHHH	18.56	30635358
653	Phosphorylation	GTQFVCETVIRSLTL CCHHHHHHHHHHCCC	18.99	30635358
657	Phosphorylation	VCETVIRSLTLDAAP HHHHHHHHCCCCCCC	18.00	26824392
659	Phosphorylation	ETVIRSLTLDAAPDH HHHHHHCCCCCCCCC	24.68	25619855
674	Phosphorylation	NPPCRQRSPQRELQL CCCCCCCCCCCEEEE	19.62	29899451
683	Phosphorylation	QRELQLYSTEGQQPL CCEEEEEECCCCCCE	28.68	29899451
700	Phosphorylation	PGFCRKDSSLKFALP CCEECCCCCCCEECC	40.37	22006019
703	Ubiquitination	CRKDSSLKFALPEEG ECCCCCCCEECCCCC	30.45	-
806	Phosphorylation	ERLPERESQPQEQSI HHCCCCCCCCCCCCH	54.07	23649490
812	Phosphorylation	ESQPQEQSISDILTT CCCCCCCCHHHHHHC	24.25	23649490
814	Phosphorylation	QPQEQSISDILTTSQ CCCCCCHHHHHHCCC	24.68	23649490
820	Phosphorylation	ISDILTTSQPLDTVP HHHHHHCCCCCCCCC	25.27	23649490
860	Phosphorylation	VDSPGVDSPATMHEV CCCCCCCCCCCCCCC	17.64	-
909	Ubiquitination	SIAGGLVKGALSVAA CHHHHHHHHHHHHHH	43.43	-
919	Phosphorylation	LSVAASAYKALFSGP HHHHHHHHHHHHCCC	8.36	29514104
920	Ubiquitination	SVAASAYKALFSGPP HHHHHHHHHHHCCCC	38.03	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NBR1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NBR1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NBR1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MK14_MOUSE	Mapk14	physical	20616007
SQSTM_MOUSE	Sqstm1	physical	20616007
MAP1B_MOUSE	Map1b	physical	22654911
UBB_MOUSE	Ubb	physical	19427866
UBE2O_MOUSE	Ube2o	physical	19427866
LTOR2_MOUSE	Lamtor2	physical	19427866
TMEDA_MOUSE	Tmed10	physical	19427866
UBC_MOUSE	Ubc	physical	19427866

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.