UniProt ID | NAT10_DROME | |
---|---|---|
UniProt AC | Q9W3C1 | |
Protein Name | RNA cytidine acetyltransferase {ECO:0000255|HAMAP-Rule:MF_03211} | |
Gene Name | l(1)G0020 | |
Organism | Drosophila melanogaster (Fruit fly). | |
Sequence Length | 1008 | |
Subcellular Localization | Nucleus, nucleolus . | |
Protein Description | RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (Probable). Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. [PubMed: 11493925] | |
Protein Sequence | MVKKKIDNRIRVMIENGVKLGHRTMFIVIGDKARDQVPILYDILTKSTVKARPTVLWCYKNKDEAISNHGKKRAKKIAVGKVDVNEADLFDSFRVATTIHGRYYSETHAVLGRTYGVCVLQDFEALTPNLLARTVETVEGGGLIILLLKTLQSLKQLYTMSMDVHKRFRTEAHQTVTCRFNERLILSLADCKRCLVVNDDLTVLPLSSKTINVEPVNPAGAGRSPNEASLKELKESLLTVQPAGALVNLCKTYDQANAVAQFIEALVDKQLKPPMSLTAARGRGKSAALGLSIAAAVAFGYVNIYVTSPHPENLITLFEFVLKGFDALEYQEHADYTIIRSTNADYKKAIIRINITRSSRQTIQYIAPSDTHLLNAADLLLIDEAAAIPLPLVKKMIGPYLVFMASTINGYEGTGRSLSLKLISQLQKDNNARPPLKLEESIRYQENDDIEKWLINLLCLDASTVPSISSGCPTPDACELYYVDRDALFSYHKAAEAFLHRLVSIYVSSHYKNTPNDLQMMSDAPAHHLFCLLGPVQRMDALPEILVVIQVALEGQISAQSISDSLGRGKKAAGDLIPWNVAEQYGDRDFPKLCGVRIVRVATHPNYQRMGYGKRAIQLLKDYYARKHTNLEDGPVASKDAGKGIEEVEEEELSLLKEQIRPRSRIPTLLQRLHERVPEHVDYIGTSYGLTTELLKFWKNAGFVPVYLSQKSNELTAEHSCIMLHTPNATPWLGLYYQDFRRRVLKLMGKTFREFETKLCLALLKNKSVDTEGSALKVLDKPMLDVYFLPHDLQRLESYARQQSEFRLIIDLLTDIAQLYFQGRIDGLQLDLVQQGILLALGVQGKTVDALGLELNMPGNQLLAKFFDAMKRCNQCFRSVLEEHIEGGMLREADLSKGEELQPLTLSLDKELDQTAQKLSKQQRKELKRLKAEQLDEFQIKGTEEDWSKALETNGTGGGSGLLSVKSGVKRLDGPIETREDGDLAAPLSKKKKKNNPKQRRSQGKSLI | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
664 | Phosphorylation | KEQIRPRSRIPTLLQ HHHHCCCCHHHHHHH | 27626673 | ||
896 | Phosphorylation | MLREADLSKGEELQP CCCHHCCCCCCCCCC | 22817900 | ||
907 | Phosphorylation | ELQPLTLSLDKELDQ CCCCEECCCHHHHHH | 18327897 | ||
960 | Phosphorylation | TNGTGGGSGLLSVKS CCCCCCCCCCEEECC | 22817900 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NAT10_DROME !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NAT10_DROME !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NAT10_DROME !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
NOG1_DROME | Non1 | physical | 22036573 | |
NOC3L_DROME | CG1234 | physical | 22036573 | |
RRP12_DROME | CG2691 | physical | 22036573 | |
Y8611_DROME | CG8611 | physical | 22036573 | |
PESC_DROME | CG4364 | physical | 22036573 | |
GNL3_DROME | Ns1 | physical | 22036573 |
Kegg Drug | ||||||
---|---|---|---|---|---|---|
DrugBank | ||||||
There are no disease associations of PTM sites. |
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