dbPTM

Y8611_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	Y8611_DROME
UniProt AC	Q86B47
Protein Name	Probable ATP-dependent RNA helicase CG8611
Gene Name	CG8611
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	975
Subcellular Localization
Protein Description	Probable ATP-dependent RNA helicase..
Protein Sequence	MVENISLNVTVKSSARKNQQQSPALSVKKRAQKSQDFDFQFNVDKPKVKAIVVRRRAPPSKVEPTNSSVPNTTKSPTPSVSSSKSAISTLSASPKANASNDDLMFNVSPTKPPVKSVLGDDFMLNVTTKPVVAQKAKPKITRAERLGKKQRQGKPLTKLSEEQITRALKSNKKPKNPNQLPTPGDLFRAQLEEERRQKRREEGGGDQEASADEEDAKNNSGGGSPRVKPSSAVKESKKSSDIEDSGESGEESATSDEEPDESSAQSPGQEKEPKQTAKKPPKAEETSSTNRFRTKKIGLFDQSDVEALKQLGQRAVKPVKETIFTGSKISTLGLHPHAVKNLEDLLSIRELTSVQQKTIPEVLQGKDVLVRSQTGSGKTLAYALPLVELLQKQQPRIQRKDGVLALVIVPTRELVMQTYELIQKLVKPYTWIVPGSLLGGESRKSEKARLRKGINILIGTPGRLVDHLLHTASFKLTKLQFLILDEADRLLELGYERDVKQLVEAIDKQRAECEDKELPQLQRMLLSATLTSQVQQLAGLTLKNPLYIDNSDEAASAALKSKDGYQKETIEALLEVDDGLGEYQEDVTGVLSIPENLQLSYVVVPPKLRLVALSSLLAKEVDASPKQFKAIVFMSTTEMVNFHHDMLNEALTRRVLDEEDEQEKGDSDDDGDIPLLQGLRFFKLHGSMTQTERQGVFRGFRDCASCVLLATDVVGRGIDVPDIKLVVQYTPPQTTADFVHRVGRTARAGRKGRAVLFLTPSEAQFVRHLEKKRIRIQQGDMYAYLQTLLPKDDEARTVQEAASNLQHKFQTLLEDDRELHDKSCKAFVSWMKFYSTFPKELKPIFNVRIAHMGHFAKSFALKEAPSKFAAKHAAPKAAPPTNRLTYTERDPEKIQAQKRAKRRFTTTVSGEVRQLQQRDVGAQKPGAPPPKGGFIGGGVGRSSFMKSLGKSRALNMSEFDSGLPPEGAAKRRKQA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21 (in isoform 2)	Phosphorylation	-	41.43	19429919
22	Phosphorylation	ARKNQQQSPALSVKK HHCCCCCCCCHHHHH	14.06	19429919
68	Phosphorylation	KVEPTNSSVPNTTKS CCCCCCCCCCCCCCC	43.60	23607784
72	Phosphorylation	TNSSVPNTTKSPTPS CCCCCCCCCCCCCCC	29.54	23607784
73	Phosphorylation	NSSVPNTTKSPTPSV CCCCCCCCCCCCCCC	35.84	23607784
75	Phosphorylation	SVPNTTKSPTPSVSS CCCCCCCCCCCCCCC	31.73	23607784
77	Phosphorylation	PNTTKSPTPSVSSSK CCCCCCCCCCCCCCC	34.97	23607784
79	Phosphorylation	TTKSPTPSVSSSKSA CCCCCCCCCCCCCCH	36.79	23607784
81	Phosphorylation	KSPTPSVSSSKSAIS CCCCCCCCCCCCHHH	32.98	23607784
82	Phosphorylation	SPTPSVSSSKSAIST CCCCCCCCCCCHHHH	39.36	23607784
83	Phosphorylation	PTPSVSSSKSAISTL CCCCCCCCCCHHHHH	24.11	23607784
88	Phosphorylation	SSSKSAISTLSASPK CCCCCHHHHHCCCCC	24.02	19429919
89	Phosphorylation	SSKSAISTLSASPKA CCCCHHHHHCCCCCC	20.72	19429919
91	Phosphorylation	KSAISTLSASPKANA CCHHHHHCCCCCCCC	27.13	29892262
93	Phosphorylation	AISTLSASPKANASN HHHHHCCCCCCCCCC	24.45	19429919
99	Phosphorylation	ASPKANASNDDLMFN CCCCCCCCCCCCCEE	40.37	22817900
108	Phosphorylation	DDLMFNVSPTKPPVK CCCCEECCCCCCCCC	28.14	21082442
210	Phosphorylation	GGGDQEASADEEDAK CCCCCCCCCCHHHHH	35.18	19429919
220	Phosphorylation	EEDAKNNSGGGSPRV HHHHHHCCCCCCCCC	48.48	25749252
224	Phosphorylation	KNNSGGGSPRVKPSS HHCCCCCCCCCCCCH	16.89	25749252
667	Phosphorylation	DEQEKGDSDDDGDIP HHHHCCCCCCCCCCC	52.16	10731138

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of Y8611_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of Y8611_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of Y8611_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of Y8611_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75; SER-99; SER-210;SER-220 AND SER-224, AND MASS SPECTROMETRY.	18327897 [Abstract]
"An integrated chemical, mass spectrometric and computational strategyfor (quantitative) phosphoproteomics: application to Drosophilamelanogaster Kc167 cells."; Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D.,Juenger M.A., Eng J.K., Aebersold R., Tao W.A.; Mol. Biosyst. 3:275-286(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-667, AND MASSSPECTROMETRY.	17372656 [Abstract]