dbPTM

NOC3L_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NOC3L_DROME
UniProt AC	Q9VI82
Protein Name	Nucleolar complex protein 3 homolog
Gene Name	CG1234
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	822
Subcellular Localization	Nucleus, nucleolus.
Protein Description
Protein Sequence	MGTKKVKISSVKRAAHLKSKKTPLSKQQQQKQKQKRDQLKSKREQGQNIFSQKARKRDNLAQRKKHNKLASLGLDPLEEDNEDGDDEMLENVADMLDGDDLALLQANKRKRKAKTTGENDPDQGQSIGLERAYASDTKKEQDAQKIKLDLLPIKSRDGQIITRTTEVDYIPKPKQKKKNEEEEEDDSEEDGDTEYEDSDDDVVNDVEAATAAPVQKLISTTDLLIARQQEIERQKYRIGIICSGLLEKPEDKMRNFHALYELMDEINPASRQANLMAVRKLAIISVTEIFKDILPEYRVGQVDTKMQTLRKATLDRVTFENALLQQFKKFLQKLEQITAQVNRRGGLRTPQTVKLATVAVQCMCDLLVAHPYFNYVQNIAQLLVYMLNCNYAEMRTAVHQCFRTVFSNDKRLEMTLFIVRRINHLIKTKQNNVHVECITCLMGLKIKNVNLDAEKENELKQKKLESHRQRLLSLSKKERKRRKKLTEVNRELEETRAEENKQAKHQKLTEIIKMVFTIYFRVLKNDPTSRVLSAILEGLAEFAHVINLDFFSDLIDVLNRILEDQDELGYRERLHCVQTIFVILSGQGEVLNIDPIRFYQHFYRNMLAVQAGKNHDDFAIILRTLDEVLVKRRRNMSQQRLMAFMKRLLTGSLHLLHNGTLATLGTIKQTFQLTSVLDNLLDTDTTIGSGRYDPELDDPEYCNAASTALYELALLARHYHPTVRRMAVHIAHGVPATGEGALPTEIGKLTSHELFTQFDSTQMAFNPTIPLPKAGQPKLKRGKHLYIRSDFKQEYGKLLQQGKVSQTKDKQTLQIDFFSALQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
187	Phosphorylation	EEEEEDDSEEDGDTE HHHCCCCCCCCCCCC	56.03	23607784
193	Phosphorylation	DSEEDGDTEYEDSDD CCCCCCCCCCCCCCC	46.10	23607784
195	Phosphorylation	EEDGDTEYEDSDDDV CCCCCCCCCCCCCCH	27.42	23607784
198	Phosphorylation	GDTEYEDSDDDVVND CCCCCCCCCCCHHCH	30.88	23607784

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NOC3L_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NOC3L_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NOC3L_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NOC3L_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-187; THR-193 ANDSER-198, AND MASS SPECTROMETRY.	18327897 [Abstract]