MTA70_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MTA70_DROME
• UniProt AC: Q9VCE6
• Protein Name: N6-adenosine-methyltransferase MT-A70-like protein
• Gene Name: Ime4 {ECO:0000303|PubMed:27919081, ECO:0000303|PubMed:28675155}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 608
• Subcellular Localization: Nucleus .
• Protein Description: Catalytic component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and is required for sex determination. [PubMed: 27919077]
• Protein Sequence: MADAWDIKSLKTKRNTLREKLEKRKKERIEILSDIQEDLTNPKKELVEADLEVQKEVLQALSSCSLALPIVSTQVVEKIAGSSLEMVNFILGKLANQGAIVIRNVTIGTEAGCEIISVQPKELKEILEDTNDTCQQKEEEAKRKLEVDDVDQPQEKTIKLESTVARKESTSLDAPDDIMMLLSMPSTREKQSKQVGEEILELLTKPTAKERSVAEKFKSHGGAQVMEFCSHGTKVECLKAQQATAEMAAKKKQERRDEKELRPDVDAGENVTGKVPKTESAAEDGEIIAEVINNCEAESQESTDGSDTCSSETTDKCTKLHFKKIIQAHTDESLGDCSFLNTCFHMATCKYVHYEVDTLPHINTNKPTDVKTKLSLKRSVDSSCTLYPPQWIQCDLRFLDMTVLGKFAVVMADPPWDIHMELPYGTMSDDEMRALGVPALQDDGLIFLWVTGRAMELGRDCLKLWGYERVDELIWVKTNQLQRIIRTGRTGHWLNHGKEHCLVGMKGNPTNLNRGLDCDVIVAEVRATSHKPDEIYGIIERLSPGTRKIELFGRPHNIQPNWITLGNQLDGIRLVDPELITQFQKRYPDGNCMSPASANAASINGIQK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
169	Phosphorylation	STVARKESTSLDAPD EHHHCCCCCCCCCCH	26.74	19429919
170	Phosphorylation	TVARKESTSLDAPDD HHHCCCCCCCCCCHH	34.11	19429919
171	Phosphorylation	VARKESTSLDAPDDI HHCCCCCCCCCCHHH	33.27	19429919
183	Phosphorylation	DDIMMLLSMPSTREK HHHHHHHHCCCCHHH	25.37	19429919
186	Phosphorylation	MMLLSMPSTREKQSK HHHHHCCCCHHHHHH	31.30	19429919
187	Phosphorylation	MLLSMPSTREKQSKQ HHHHCCCCHHHHHHH	36.66	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MTA70_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MTA70_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MTA70_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MSS4_DROME	CG7787	physical	14605208
MET14_DROME	CG7818	physical	14605208
DTBP1_DROME	Dysb	physical	14605208
NOTCH_DROME	N	genetic	21873203

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.