MT21C_HUMAN - dbPTM
MT21C_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MT21C_HUMAN
UniProt AC Q5VZV1
Protein Name Protein-lysine methyltransferase METTL21C
Gene Name METTL21C
Organism Homo sapiens (Human).
Sequence Length 264
Subcellular Localization Nucleus .
Protein Description Protein-lysine methyltransferase..
Protein Sequence MDVCLSSAQQPGRRGEGLSSPGGWLEAEKKGAPQKDSTGGVLEESNKIEPSLHSLQKFVPTDYASYTQEHYRFAGKEIVIQESIESYGAVVWPGAMALCQYLEEHAEELNFQDAKILEIGAGPGLVSIVASILGAQVTATDLPDVLGNLQYNLLKNTLQCTAHLPEVKELVWGEDLDKNFPKSAFYYDYVLASDVVYHHYFLDKLLTTMVYLSQPGTVLLWANKFRFSTDYEFLDKFKQVFDTTLLAEYPESSVKLFKGILKWD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
19PhosphorylationGRRGEGLSSPGGWLE
CCCCCCCCCCCCCHH		45.39-
37PhosphorylationKGAPQKDSTGGVLEE
CCCCCCCCCCCHHCC		35.67-
38PhosphorylationGAPQKDSTGGVLEES
CCCCCCCCCCHHCCC		48.35-
45PhosphorylationTGGVLEESNKIEPSL
CCCHHCCCCCCCCCH		33.76-
183PhosphorylationLDKNFPKSAFYYDYV
CCCCCCCHHHHHCHH		24.6923663014
186PhosphorylationNFPKSAFYYDYVLAS
CCCCHHHHHCHHCHH		8.6423663014
187PhosphorylationFPKSAFYYDYVLASD
CCCHHHHHCHHCHHH		8.3723663014
189PhosphorylationKSAFYYDYVLASDVV
CHHHHHCHHCHHHHH		4.9323663014
193PhosphorylationYYDYVLASDVVYHHY
HHCHHCHHHHHHHHH		27.1223663014
197PhosphorylationVLASDVVYHHYFLDK
HCHHHHHHHHHHHHH		5.2423663014
200PhosphorylationSDVVYHHYFLDKLLT
HHHHHHHHHHHHHHH		7.7923663014
224AcetylationTVLLWANKFRFSTDY
EEEEEECCCCCCCCH		30.1230586627
243PhosphorylationKFKQVFDTTLLAEYP
HHHHHCCCHHHHHCC		14.1029083192
244PhosphorylationFKQVFDTTLLAEYPE
HHHHCCCHHHHHCCH		22.9429083192
249PhosphorylationDTTLLAEYPESSVKL
CCHHHHHCCHHHHHH		13.4929083192
252PhosphorylationLLAEYPESSVKLFKG
HHHHCCHHHHHHHHH		35.6129083192
253PhosphorylationLAEYPESSVKLFKGI
HHHCCHHHHHHHHHH		22.9329083192
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MT21C_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MT21C_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MT21C_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CARM1_HUMANCARM1physical
23349634
GRDN_HUMANCCDC88Aphysical
23349634
TCPG_HUMANCCT3physical
23349634
DYHC1_HUMANDYNC1H1physical
23349634
TF3C4_HUMANGTF3C4physical
23349634
HS71L_HUMANHSPA1Lphysical
23349634
GRP78_HUMANHSPA5physical
23349634
HSP7C_HUMANHSPA8physical
23349634
KDM1A_HUMANKDM1Aphysical
23349634
MD1L1_HUMANMAD1L1physical
23349634
MT21A_HUMANMETTL21Aphysical
23349634
TBB2A_HUMANTUBB2Aphysical
23349634
GCP2_HUMANTUBGCP2physical
23349634
UBB_HUMANUBBphysical
23349634
UBC_HUMANUBCphysical
23349634
BCKD_HUMANBCKDKphysical
26186194
BCKD_HUMANBCKDKphysical
28514442
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MT21C_HUMAN

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Related Literatures of Post-Translational Modification

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