MPK18_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MPK18_ARATH
• UniProt AC: Q9C5C0
• Protein Name: Mitogen-activated protein kinase 18
• Gene Name: MPK18
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 615
• Subcellular Localization: Cytoplasm .
• Protein Description: Mitogen-activated protein kinase (MAPK) that is specifically regulated by PHS1 and mediates signaling that regulates cortical microtubule functions, maybe through regulation of microtubule dynamic instability..
• Protein Sequence: MQQNQVKKGTKEMEFFTEYGDANRYRILEVIGKGSYGVVCAAIDTHTGEKVAIKKINDVFEHISDALRILREVKLLRLLRHPDIVEIKSIMLPPSKREFKDIYVVFELMESDLHQVIKANDDLTREHHQFFLYQMLRALKFMHTANVYHRDLKPKNILANANCKLKVCDFGLARVAFNDTPTTVFWTDYVATRWYRAPELCGSFFSKYTPAIDVWSIGCIFAEVLTGKPLFPGKSVVHQLELITDLLGTPKSETISGVRNDKARKYLTEMRKKNPVTFSQKFSKADPLALRLLQRLLAFDPKDRPTPAEALADPYFKGLSKIEREPSSQQISKMEFEFERRRLTKDDIRELIYREILEYHPQLLKDYMSGSEGSNFVYPSAIGHLRQQFTYLEENSSRNGPVIPLERKHASLPRSTVHSTVVHSTSQPNLGATDSRRVSFEPSKNGASSAGHPSTSAYPTKSIGPPPRVPPSGRPGRVVESSVSYENGRNLKEAYFRSAVSSPHCYFRPNTMTNPENRNIEASSFPPKPQNPVHQFSPTEPPAATTNQADVETMNHPNPYFQPQLPKTDQLNNNTHMAIDAKLLQAQSQFGPAGAAAVAVAAHRNIGTISYSAAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
180	Phosphorylation	ARVAFNDTPTTVFWT EEEECCCCCCCEEEE	24.52	30407730
182	Phosphorylation	VAFNDTPTTVFWTDY EECCCCCCCEEEEHH	37.37	30407730
183	Phosphorylation	AFNDTPTTVFWTDYV ECCCCCCCEEEEHHC	18.21	30407730
187	Phosphorylation	TPTTVFWTDYVATRW CCCCEEEEHHCCCCC	13.14	23111157
189	Phosphorylation	TTVFWTDYVATRWYR CCEEEEHHCCCCCCC	5.66	23111157
192	Phosphorylation	FWTDYVATRWYRAPE EEEHHCCCCCCCCHH	16.22	30407730
411	Phosphorylation	PLERKHASLPRSTVH CCCHHCCCCCCCEEE	38.33	29654922
425	Phosphorylation	HSTVVHSTSQPNLGA EEEEEECCCCCCCCC	19.26	25561503
426	Phosphorylation	STVVHSTSQPNLGAT EEEEECCCCCCCCCC	46.81	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MPK18_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
187	T	Phosphorylation	Dually phosphorylated on Thr-187 and Tyr-189, which activates the enzyme (By similarity).	28848569

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MPK18_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CLAH2_ARATH	AT3G08530	physical	21798944
PUB14_ARATH	PUB14	physical	21798944
2AB2A_ARATH	AT5G44090	physical	21798944
RGA_ARATH	RGA1	physical	21798944
MPK18_ARATH	MPK18	physical	19392697

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.