MPK18_ARATH - dbPTM
MPK18_ARATH - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MPK18_ARATH
UniProt AC Q9C5C0
Protein Name Mitogen-activated protein kinase 18
Gene Name MPK18
Organism Arabidopsis thaliana (Mouse-ear cress).
Sequence Length 615
Subcellular Localization Cytoplasm .
Protein Description Mitogen-activated protein kinase (MAPK) that is specifically regulated by PHS1 and mediates signaling that regulates cortical microtubule functions, maybe through regulation of microtubule dynamic instability..
Protein Sequence MQQNQVKKGTKEMEFFTEYGDANRYRILEVIGKGSYGVVCAAIDTHTGEKVAIKKINDVFEHISDALRILREVKLLRLLRHPDIVEIKSIMLPPSKREFKDIYVVFELMESDLHQVIKANDDLTREHHQFFLYQMLRALKFMHTANVYHRDLKPKNILANANCKLKVCDFGLARVAFNDTPTTVFWTDYVATRWYRAPELCGSFFSKYTPAIDVWSIGCIFAEVLTGKPLFPGKSVVHQLELITDLLGTPKSETISGVRNDKARKYLTEMRKKNPVTFSQKFSKADPLALRLLQRLLAFDPKDRPTPAEALADPYFKGLSKIEREPSSQQISKMEFEFERRRLTKDDIRELIYREILEYHPQLLKDYMSGSEGSNFVYPSAIGHLRQQFTYLEENSSRNGPVIPLERKHASLPRSTVHSTVVHSTSQPNLGATDSRRVSFEPSKNGASSAGHPSTSAYPTKSIGPPPRVPPSGRPGRVVESSVSYENGRNLKEAYFRSAVSSPHCYFRPNTMTNPENRNIEASSFPPKPQNPVHQFSPTEPPAATTNQADVETMNHPNPYFQPQLPKTDQLNNNTHMAIDAKLLQAQSQFGPAGAAAVAVAAHRNIGTISYSAAS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
180PhosphorylationARVAFNDTPTTVFWT
EEEECCCCCCCEEEE
24.5230407730
182PhosphorylationVAFNDTPTTVFWTDY
EECCCCCCCEEEEHH
37.3730407730
183PhosphorylationAFNDTPTTVFWTDYV
ECCCCCCCEEEEHHC
18.2130407730
187PhosphorylationTPTTVFWTDYVATRW
CCCCEEEEHHCCCCC
13.1423111157
189PhosphorylationTTVFWTDYVATRWYR
CCEEEEHHCCCCCCC
5.6623111157
192PhosphorylationFWTDYVATRWYRAPE
EEEHHCCCCCCCCHH
16.2230407730
411PhosphorylationPLERKHASLPRSTVH
CCCHHCCCCCCCEEE
38.3329654922
425PhosphorylationHSTVVHSTSQPNLGA
EEEEEECCCCCCCCC
19.2625561503
426PhosphorylationSTVVHSTSQPNLGAT
EEEEECCCCCCCCCC
46.8125561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MPK18_ARATH !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
187TPhosphorylation

28848569

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MPK18_ARATH !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CLAH2_ARATHAT3G08530physical
21798944
PUB14_ARATHPUB14physical
21798944
2AB2A_ARATHAT5G44090physical
21798944
RGA_ARATHRGA1physical
21798944
MPK18_ARATHMPK18physical
19392697

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MPK18_ARATH

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Related Literatures of Post-Translational Modification

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