MIS_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MIS_HUMAN
• UniProt AC: P03971
• Protein Name: Muellerian-inhibiting factor
• Gene Name: AMH
• Organism: Homo sapiens (Human).
• Sequence Length: 560
• Subcellular Localization: Secreted.
• Protein Description: This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin..
• Protein Sequence: MRDLPLTSLALVLSALGALLGTEALRAEEPAVGTSGLIFREDLDWPPGSPQEPLCLVALGGDSNGSSSPLRVVGALSAYEQAFLGAVQRARWGPRDLATFGVCNTGDRQAALPSLRRLGAWLRDPGGQRLVVLHLEEVTWEPTPSLRFQEPPPGGAGPPELALLVLYPGPGPEVTVTRAGLPGAQSLCPSRDTRYLVLAVDRPAGAWRGSGLALTLQPRGEDSRLSTARLQALLFGDDHRCFTRMTPALLLLPRSEPAPLPAHGQLDTVPFPPPRPSAELEESPPSADPFLETLTRLVRALRVPPARASAPRLALDPDALAGFPQGLVNLSDPAALERLLDGEEPLLLLLRPTAATTGDPAPLHDPTSAPWATALARRVAAELQAAAAELRSLPGLPPATAPLLARLLALCPGGPGGLGDPLRALLLLKALQGLRVEWRGRDPRGPGRAQRSAGATAADGPCALRELSVDLRAERSVLIPETYQANNCQGVCGWPQSDRNPRYGNHVVLLLKMQVRGAALARPPCCVPTAYAGKLLISLSEERISAHHVPNMVATECGCR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MRDLPLTSLALVLS -CCCCCHHHHHHHHH	21.54	50564937
8	Phosphorylation	MRDLPLTSLALVLSA CCCCCHHHHHHHHHH	21.23	50564933
14	Phosphorylation	TSLALVLSALGALLG HHHHHHHHHHHHHHC	17.61	24043423
22	Phosphorylation	ALGALLGTEALRAEE HHHHHHCHHHHHCCC	20.32	50564945
34	Phosphorylation	AEEPAVGTSGLIFRE CCCCCCCCCCEEEEC	17.02	25690035
35	Phosphorylation	EEPAVGTSGLIFRED CCCCCCCCCEEEECC	26.18	46162873
63	Phosphorylation	LVALGGDSNGSSSPL EEEECCCCCCCCCCH	46.49	28787133
64	N-linked_Glycosylation	VALGGDSNGSSSPLR EEECCCCCCCCCCHH	60.14	UniProtKB CARBOHYD
66	Phosphorylation	LGGDSNGSSSPLRVV ECCCCCCCCCCHHHH	31.71	28787133
67	Phosphorylation	GGDSNGSSSPLRVVG CCCCCCCCCCHHHHH	37.06	28787133
114	Phosphorylation	DRQAALPSLRRLGAW CHHHHCHHHHHHCHH	35.04	24719451
145	Phosphorylation	VTWEPTPSLRFQEPP EECCCCCCCCCCCCC	34.35	24719451
190	Phosphorylation	GAQSLCPSRDTRYLV CHHHCCCCCCCEEEE	41.62	46162867
195	Phosphorylation	CPSRDTRYLVLAVDR CCCCCCEEEEEEEEC	11.85	19664994
329	N-linked_Glycosylation	GFPQGLVNLSDPAAL CCCCCCCCCCCHHHH	38.58	UniProtKB CARBOHYD
331	Phosphorylation	PQGLVNLSDPAALER CCCCCCCCCHHHHHH	36.02	28787133
353	O-linked_Glycosylation	LLLLLRPTAATTGDP EEEEECCCCCCCCCC	23.61	OGP
367	O-linked_Glycosylation	PAPLHDPTSAPWATA CCCCCCCCCHHHHHH	43.51	OGP
538	Phosphorylation	YAGKLLISLSEERIS HHCHHHHCCCHHHHH	26.30	46162879
540	Phosphorylation	GKLLISLSEERISAH CHHHHCCCHHHHHHC	30.53	46162885
555	Phosphorylation	HVPNMVATECGCR-- CCCCEEHHHCCCC--	22.01	28450419

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MIS_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MIS_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MIS_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ETV5_HUMAN	ETV5	physical	21988832
ARL8B_HUMAN	ARL8B	physical	21988832
ZMAT2_HUMAN	ZMAT2	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 261550: Persistent Muellerian duct syndrome 1 (PMDS1)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.