MGRN1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MGRN1_RAT
• UniProt AC: Q5XIQ4
• Protein Name: E3 ubiquitin-protein ligase MGRN1
• Gene Name: Mgrn1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 533
• Subcellular Localization: Cytoplasm, cytosol. Cell membrane. Early endosome. The endosomal localization is dependent on the interaction with TSG101..
• Protein Description: E3 ubiquitin-protein ligase. Mediates TSG101 monoubiquitination at multiple sites. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity)..
• Protein Sequence: MGSILSRRIAGVEDIDIQANSAYRYPPKSAGNYFASHFFMGGEKFDTPHPEGYLFGENMDLNFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDTDSPTEDGEKPRVLYSLEFTFDADARVAITIYCQAVEEFVNGMTVYSCKNPSLQSETVHYKRGVSQQFSLPSFKIDFSEWKDDELNFDLDRGVFPVVIQAVVDEGDVVEVTGHAHVLLAAFEKHVDGSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSSECVVCLSDLRDTLILPCRHLCLCTSCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPISFSPVLAQSVDHDEHSNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGISDGLSQASCPLAGLDRIIENGIQKGKTQSKSPDSTLRSPSSPIHEEDEEKLSEDPEAPLPPSGVELVLQESSSPESFGTEEVGEPSLKQGSRVPSIDDVLQDGSPQHHGCSQPVPPADIYLPALGPESCSVGIEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGSILSRRI ------CCCHHHHCC	24.32	-
102	Ubiquitination	SLRLVRYKDDTDSPT CEEEEEECCCCCCCC	38.27	-
107	Phosphorylation	RYKDDTDSPTEDGEK EECCCCCCCCCCCCC	35.50	30240740
338	Phosphorylation	RKKPGALSPISFSPV HCCCCCCCCCCCCCH	21.47	30240740
390	Phosphorylation	AIPSAPLYEEITYSG CCCCCCCCEECEECC	15.51	-
425	Phosphorylation	NGIQKGKTQSKSPDS CCCCCCCCCCCCCCC	46.90	28432305
427	Phosphorylation	IQKGKTQSKSPDSTL CCCCCCCCCCCCCCC	40.09	28432305
429	Phosphorylation	KGKTQSKSPDSTLRS CCCCCCCCCCCCCCC	38.90	28432305
432	Phosphorylation	TQSKSPDSTLRSPSS CCCCCCCCCCCCCCC	32.50	28432305
433	Phosphorylation	QSKSPDSTLRSPSSP CCCCCCCCCCCCCCC	33.30	28432305
436	Phosphorylation	SPDSTLRSPSSPIHE CCCCCCCCCCCCCCH	32.04	30181290
438	Phosphorylation	DSTLRSPSSPIHEED CCCCCCCCCCCCHHH	50.41	28432305
439	Phosphorylation	STLRSPSSPIHEEDE CCCCCCCCCCCHHHH	31.12	30240740
450	Phosphorylation	EEDEEKLSEDPEAPL HHHHHHHCCCCCCCC	51.53	-
502	Phosphorylation	DDVLQDGSPQHHGCS HHHHCCCCCCCCCCC	29.67	30240740

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MGRN1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MGRN1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MGRN1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GDU1_ARATH	GDU1	physical	24036454
GDU2_ARATH	GDU2	physical	24036454
GDU3_ARATH	GDU3	physical	24036454
GDU5_ARATH	GDU5	physical	24036454

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.