MA653_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MA653_ARATH
• UniProt AC: Q9FHM4
• Protein Name: 65-kDa microtubule-associated protein 3
• Gene Name: MAP65-3
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 707
• Subcellular Localization: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, phragmoplast. Locates only to the mitotic MT arrays. Present in MT cortical arrays just before mitosis. Associates to MT in preprophase band, during anaphase, and in phragmoplast, including midzone. Distri
• Protein Description: Microtubule-associated protein that plays a critical role in organizing the mitotic microtubule array during both early and late mitosis in all plant organs. Essential for the cytokinesis, especially in roots, by maintaining the integrity of the overlapped microtubules in the phragmoplast. Required during root morphogenesis. Needed for giant cell development during root knot nematode infection, where cytokinesis is initiated but not completed..
• Protein Sequence: MASVQKDPILQVETTCGSLLFELQIIWDEVGETETDRDQMLLELERECLEVYRRKVDQANRCRAQLRQAIADAEAQLAAICSAMGERPVHIRQSDQSVGSLKQELGRILPELEEMQKRKVERRNQFIVVMEQIDSITNDIKGQGELVHSEPLIDETNLSMRKLEELHCQLQVLQKEKIDRVETIRKHLCTLYSHCSVLGMDFNEVVGQVNPTLSDPEGPRSLSDHTIEKLGAAVQKLMEVKIQRMQRLQDLATTMLELWNLMDTPIEEQQEYQHITCNIAASEHEITEANSLSEDFIKYVEAEVVRLDEVKASKMKELVLKKRSELEEICRKTHLLPVSDSAIDQTIVAIESGIVDATMVLEHLEQHISKIKEEALSRKEILERVEKWLSACDEESWLEEYNRDDNRYNAGRGAHLTLKRAEKARNLVTKLPGMVEALASKTIVWEQENGIEFLYDGIRLLSMLEEYNILRQEREEEHRRQRDQKKLQGQLIAEQEALYGSKPSPSKPLGGKKAPRMSTGGASNRRLSLGAAMHQTPKPNKKADHRHNDGALSNGRRGLDIAGLPSRKQSMNPSEMLQSPLVRKPFSPISTTVVASKANIATTTTQQLPKNNAVNEISSFATPIKNNNILRNLEEEKMMTMMMQTPKNVAAMIPIPSTPATVSVPMHTAPTPFTNNARLMSEKPEVVEYSFEERRLAFMLQSECRLV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
352	Phosphorylation	QTIVAIESGIVDATM HHHHHHHCCCCCHHH	27.92	28011693
504	Phosphorylation	ALYGSKPSPSKPLGG HHHCCCCCCCCCCCC	45.61	-
518	Phosphorylation	GKKAPRMSTGGASNR CCCCCCCCCCCCCCC	25.77	25561503
519	Phosphorylation	KKAPRMSTGGASNRR CCCCCCCCCCCCCCC	30.23	25561503
528	Phosphorylation	GASNRRLSLGAAMHQ CCCCCCCCCCCHHCC	23.97	-
587	Phosphorylation	PLVRKPFSPISTTVV CCCCCCCCCCCHHEE	29.83	30291188
622	Phosphorylation	NEISSFATPIKNNNI CHHHHCCCCCCCCCH	24.44	23328941

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MA653_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MA653_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MA653_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MAD2_ARATH	MAD2	physical	25262777
BUBR1_ARATH	BUBR1	physical	25262777
BRK1_ARATH	BRK1	physical	25262777
BUB31_ARATH	BUB3.1	physical	25262777

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.