LOXL3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LOXL3_HUMAN
• UniProt AC: P58215
• Protein Name: Lysyl oxidase homolog 3 {ECO:0000305}
• Gene Name: LOXL3 {ECO:0000303|PubMed:11386757, ECO:0000312|HGNC:HGNC:13869}
• Organism: Homo sapiens (Human).
• Sequence Length: 753
• Subcellular Localization: Secreted, extracellular space . Cytoplasm . Nucleus . It is unclear how LOXL3 is both intracellular (cytoplasmic and nuclear) and extracellular: it contains a clear signal sequence and is predicted to localize in the extracellular medium. However, th
• Protein Description: Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins. [PubMed: 17018530]
• Protein Sequence: MRPVSVWQWSPWGLLLCLLCSSCLGSPSPSTGPEKKAGSQGLRFRLAGFPRKPYEGRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCSGTEQSVTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSNVIEVEHHLQVEEVRIRPAVGWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYRLLAQRQQHSFGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQKKQQQSKPQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNLPYTGAETRIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYANHGLQETWYWDSGNITEVVMSGVRCTGTELSLDQCAHHGTHITCKRTGTRFTAGVICSETASDLLLHSALVQETAYIEDRPLHMLYCAAEENCLASSARSANWPYGHRRLLRFSSQIHNLGRADFRPKAGRHSWVWHECHGHYHSMDIFTHYDILTPNGTKVAEGHKASFCLEDTECQEDVSKRYECANFGEQGITVGCWDLYRHDIDCQWIDITDVKPGNYILQVVINPNFEVAESDFTNNAMKCNCKYDGHRIWVHNCHIGDAFSEEANRRFERYPGQTSNQII

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Phosphorylation	GPEKKAGSQGLRFRL CCCCCCCCCCCEEEE	26.40	23532336
111	N-linked_Glycosylation	TGRIWLDNLSCSGTE CCEEEEECCCCCCCC	31.51	UniProtKB CARBOHYD
153 (in isoform 3)	Phosphorylation	-	46.15	22210691
155 (in isoform 3)	Phosphorylation	-	31.62	22210691
266	N-linked_Glycosylation	SLEFYRANDTARCPG EEEEEECCCCCCCCC	37.86	UniProtKB CARBOHYD
390	N-linked_Glycosylation	LWKCPHKNITAEDCS EEECCCCCCCHHHCC	33.53	UniProtKB CARBOHYD
481	N-linked_Glycosylation	TWYWDSGNITEVVMS EEEEECCCCEEEEEC	41.79	UniProtKB CARBOHYD
553	Phosphorylation	DRPLHMLYCAAEENC CCCHHHHHHHHHHCC	3.42	28851738
564	Phosphorylation	EENCLASSARSANWP HHCCHHHCCHHCCCC	23.30	28851738
625	N-linked_Glycosylation	HYDILTPNGTKVAEG CEEEECCCCCEECCC	66.58	UniProtKB CARBOHYD
670	"2',4',5'-topaquinone"	TVGCWDLYRHDIDCQ EEECHHHHCCCCCCC	11.93	-
670	Other	TVGCWDLYRHDIDCQ EEECHHHHCCCCCCC	11.93	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LOXL3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LOXL3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LOXL3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EDEM1_HUMAN	EDEM1	physical	28514442
MSI1H_HUMAN	MSI1	physical	28514442
SUFU_HUMAN	SUFU	physical	28514442
RL23_HUMAN	RPL23	physical	28514442
GRP78_HUMAN	HSPA5	physical	28514442
VP26B_HUMAN	VPS26B	physical	28514442
SENP5_HUMAN	SENP5	physical	28514442
MSI2H_HUMAN	MSI2	physical	28514442
LTBP1_HUMAN	LTBP1	physical	28514442
KDEL1_HUMAN	KDELC1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.