LIPP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LIPP_HUMAN
• UniProt AC: P16233
• Protein Name: Pancreatic triacylglycerol lipase
• Gene Name: PNLIP
• Organism: Homo sapiens (Human).
• Sequence Length: 465
• Subcellular Localization: Secreted .
• Protein Sequence: MLPLWTLSLLLGAVAGKEVCYERLGCFSDDSPWSGITERPLHILPWSPKDVNTRFLLYTNENPNNFQEVAADSSSISGSNFKTNRKTRFIIHGFIDKGEENWLANVCKNLFKVESVNCICVDWKGGSRTGYTQASQNIRIVGAEVAYFVEFLQSAFGYSPSNVHVIGHSLGAHAAGEAGRRTNGTIGRITGLDPAEPCFQGTPELVRLDPSDAKFVDVIHTDGAPIVPNLGFGMSQVVGHLDFFPNGGVEMPGCKKNILSQIVDIDGIWEGTRDFAACNHLRSYKYYTDSIVNPDGFAGFPCASYNVFTANKCFPCPSGGCPQMGHYADRYPGKTNDVGQKFYLDTGDASNFARWRYKVSVTLSGKKVTGHILVSLFGNKGNSKQYEIFKGTLKPDSTHSNEFDSDVDVGDLQMVKFIWYNNVINPTLPRVGASKIIVETNVGKQFNFCSPETVREEVLLTLTPC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
47	Phosphorylation	PLHILPWSPKDVNTR CEEECCCCCCCCCCC	21.82	24719451
58	Phosphorylation	VNTRFLLYTNENPNN CCCCEEEEECCCCCC	15.07	22210691
59	Phosphorylation	NTRFLLYTNENPNNF CCCEEEEECCCCCCH	35.71	22210691
75	Phosphorylation	EVAADSSSISGSNFK HHHCCCCCCCCCCCC	25.40	22210691
183	N-linked_Glycosylation	GEAGRRTNGTIGRIT HHCHHCCCCCCEECC	43.74	UniProtKB CARBOHYD
185	Phosphorylation	AGRRTNGTIGRITGL CHHCCCCCCEECCCC	23.48	-
334	Acetylation	YADRYPGKTNDVGQK CCCCCCCCCCCCCCE	39.38	7825045
335	Phosphorylation	ADRYPGKTNDVGQKF CCCCCCCCCCCCCEE	42.43	-
360	Phosphorylation	ARWRYKVSVTLSGKK CEEEEEEEEEECCCE	12.77	24719451
364	Phosphorylation	YKVSVTLSGKKVTGH EEEEEEECCCEEEEE	38.92	24719451
420	Phosphorylation	QMVKFIWYNNVINPT EEEEEEEECCCCCCC	7.64	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LIPP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LIPP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LIPP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LMF1_HUMAN	LMF1	physical	19783858
LIPR2_HUMAN	PNLIPRP2	physical	28514442
EKI1_HUMAN	ETNK1	physical	28514442
ZN444_HUMAN	ZNF444	physical	28514442
SUMF1_HUMAN	SUMF1	physical	28514442
ZN787_HUMAN	ZNF787	physical	28514442
RSAD1_HUMAN	RSAD1	physical	28514442
LAMC1_HUMAN	LAMC1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.