KTU_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KTU_DROME
• UniProt AC: Q0E9G3
• Protein Name: Protein kintoun {ECO:0000255|HAMAP-Rule:MF_03069}
• Gene Name: Nop17l {ECO:0000255|HAMAP-Rule:MF_03069}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 834
• Subcellular Localization: Cytoplasm .
• Protein Description: Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment..
• Protein Sequence: MSASRSRNKQSKLCDDERLDISRDEFNRFQEAFGKEEFRKLFFDYVDEIQDPENRKIYESEITQLEKERGVEVRFIHPKPGFVIKTALDGELKCFINIASCEEIQRPKNEVATDPSSGSRGLSWSIPMAQTTSRDDFDAKNNHCKVFDVVFHPDALHLAMRNKQFRQCLIDTALDAIEREYKVSLDRANLKFPKLDYKGIPRPTVIRKMADNPTAEEQEPHPLAHMFPTKPPAPGKQEPRVLPMKTKPSPVPEFTVPRYTIKHSHDVDLSEYTDELDAKLHVTVPRSLVVEIELPLLRSTAECQLDVTSKSIYLFSERQGAKYRLKLDLPFIVDDKAGRARFDTDMRRLSITLPVVRKSIQEQAQMHETLRHFSREDSGVELHSNSESPVEEDPDGELSDSKADISETSSPSVAPANSPFLKSSVHYQLPSKFDCNVLDNVMAFVLHVPNVQPDSIEQLREQRSLHLKFATIGSGYYPTHYAFYVELSAEHEDSSIESAEAEAWDNNVVLKLCLNSQSETPASYLAGLDATELKEYPVHGQYHVKSKGKVNAKKDNAPLDVKFERNQEGHALKVTIRPGTKEEEEDKENQDQEPESDQQQQQQVQNKKPGKKQRKKNKKERSLSESACADMILQEPLAKTNELQPRATFKLPPQRKQRSYSECNDSTGRSHRGILKRFSRYGPRPSMSDSWSSIDDSSSYSCSVDASGTSLFSQSFGGIPEEDRSDAGLSESCKKTVRFNDHIMKQVFRLDSSILGQRKKNQKRRDLKLRAQQRRLSEGDSVDYEETRGSALKQEENPSRNCNDSGLDLTGAAGAHSNNNESDAKNTMMFEMDD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
350	Phosphorylation	DTDMRRLSITLPVVR CCCCHHHHEEHHHHH	16.24	19429919
352	Phosphorylation	DMRRLSITLPVVRKS CCHHHHEEHHHHHHH	22.95	19429919
378	Phosphorylation	RHFSREDSGVELHSN HHHHHHCCCCEECCC	39.73	19429919
384	Phosphorylation	DSGVELHSNSESPVE CCCCEECCCCCCCCC	55.46	19429919
386	Phosphorylation	GVELHSNSESPVEED CCEECCCCCCCCCCC	42.33	19429919
388	Phosphorylation	ELHSNSESPVEEDPD EECCCCCCCCCCCCC	33.78	22817900
596	Phosphorylation	NQDQEPESDQQQQQQ CCCCCCHHHHHHHHH	51.97	30478224
659	Phosphorylation	PPQRKQRSYSECNDS CCHHHCCCHHHCCCC	30.43	27626673
661	Phosphorylation	QRKQRSYSECNDSTG HHHCCCHHHCCCCCC	36.60	29892262
666	Phosphorylation	SYSECNDSTGRSHRG CHHHCCCCCCCCHHH	20.83	27626673
777	Phosphorylation	RAQQRRLSEGDSVDY HHHHHHHCCCCCCCH	37.41	19429919
781	Phosphorylation	RRLSEGDSVDYEETR HHHCCCCCCCHHHHH	27.95	27626673
805	Phosphorylation	PSRNCNDSGLDLTGA CCCCCCCCCCCCCCC	27.54	29892262

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KTU_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KTU_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KTU_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PP12_DROME	Pp1-87B	physical	14605208
PP11_DROME	Pp1alpha-96A	physical	14605208
SGO1_DROME	mei-S332	physical	14605208
PP1B_DROME	flw	genetic	17007873
PP12_DROME	Pp1-87B	genetic	17007873
PP11_DROME	Pp1alpha-96A	physical	17007873
PP1B_DROME	flw	physical	17007873
PP13_DROME	Pp1-13C	physical	17007873
PP12_DROME	Pp1-87B	physical	17007873

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.