KHDR3_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KHDR3_RAT
• UniProt AC: Q9JLP1
• Protein Name: KH domain-containing, RNA-binding, signal transduction-associated protein 3
• Gene Name: Khdrbs3
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 346
• Subcellular Localization: Nucleus .
• Protein Description: RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. [PubMed: 11118435 Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro. Binds optimally to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A RNA-binding abilities are down-regulated by tyrosine kinase PTK6 (By similarity Involved in splice site selection of vascular endothelial growth factor. In vitro regulates CD44 alternative splicing by direct binding to purine-rich exonic enhancer]
• Protein Sequence: MEEKYLPELMAEKDSLDPSFTHALRLVNREIEKFQKGEAKDEEKYIDVVINKNMKLGQKVLIPVKQFPKFNFVGKLLGPRGNSLKRLQEETLTKMSILGKGSMRDKAKEEELRKSGEAKYFHLNDDLHVLIEVFAPPAEAYARMGHALEDIKKFLIPDYNDEIRQAQLQELTYLNGGSENADVPVVRGKSTLRTRGVTTPAITRGRGGVTARPVAVGVPRGTPTPRGVLSTRGPVSRGRGLLTPRARGVPPTGYRPPPPPPTQETYGEYDYDDGYSTAYDDQSYDSYDNSYSTPAQSGADYYDYGHGLGEEAYDSYGQEDWTNSRHKAPSARTAKGVYREQPYGRY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
65	Acetylation	QKVLIPVKQFPKFNF CEEEEEHHHCCCCCC	40.65	22902405
75	Acetylation	PKFNFVGKLLGPRGN CCCCCCHHHHCCCCH	34.93	72622543
187	Methylation	NADVPVVRGKSTLRT CCCCCEECCCCEEEC	47.24	20678973
220	Methylation	PVAVGVPRGTPTPRG CEEECCCCCCCCCCC	60.24	26494687

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KHDR3_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KHDR3_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KHDR3_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KHDR1_HUMAN	KHDRBS1	physical	11118435
YTDC1_HUMAN	YTHDC1	physical	11118435
SRSF9_HUMAN	SRSF9	physical	11118435
HNRPL_HUMAN	HNRNPL	physical	11118435
RBMX_HUMAN	RBMX	physical	11118435
SAFB1_HUMAN	SAFB	physical	11118435
KHDR1_RAT	Khdrbs1	physical	11118435
RBMX_RAT	Rbmx	physical	11118435
SAFB1_RAT	Safb	physical	11118435
YTDC1_RAT	Ythdc1	physical	11118435

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.