YTDC1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: YTDC1_RAT
• UniProt AC: Q9QY02
• Protein Name: YTH domain-containing protein 1
• Gene Name: Ythdc1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 738
• Subcellular Localization: Nucleus . Nucleus speckle . Localizes to a novel subnuclear structure, the YT bodies.
• Protein Description: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and acts as a regulator of alternative splicing. [PubMed: 25389274 M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability]
• Protein Sequence: MAADSREEKDGELNVLDDILTEVPEQDDELYNPESEQDKNEKKGSKRKSERMESIDTKRQKPSIHSRQLISKPLSSSVSNNKRIVSTKGKSVTEYKNEEYQRSERNKRLDADRKIRLSSSSSREPYKSQPEKPCLRKRDSERRAKSPTPDGSERIGLEVDRRASRSSQSSKEEGNSEEYGSDHETGSSASSEQGNNTENEEEGGEEDVEEDEEVDEDGDDDEEVDEDAEEEEDEEEDEEEEDEEEEEEEEEEYEQDERDQKEEGNDYDTRSEASDSGSESVSFTDGSVRSGSGTDGSDEKKKERKRARGISPIVFDRSGSSASESYAGSEKKHEKLSSSVRAVRKDQTSKLKYVLQDARFFLIKSNNHENVSLAKAKGVWSTLPVNEKKLNLAFRSARSVILIFSVRESGKFQGFARLSSESHHGGSPIHWVLPAGMSAKMLGGVFKIDWICRRELPFTKSAHLTNPWNEHKPVKIGRDGQEIELECGTQLCLLFPPDESIDLYQLIHKMRHKRRMHSQPRSRGRPSRREPVRDVGRRRPEDYDIHNSRKKPRIDYPPEFHQRPGYLKDPRYQEVDSFTNLIPNRRFSGVRRDVFLNGSYNDYVREFHNMGPPPPWQGMPPYPGIEQPPHHPYYQHHAPPPQAHPPYSGHHPVPHEARYRDKRVHDYDMRVDDFLRRTQAVVSGRRSRPRERDRERERDRPRDNRRDRERDRGRDRERERERICDRDRDRGERGRYRR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
35	Phosphorylation	DELYNPESEQDKNEK CCCCCCCCCCCCCCC	41.64	22673903
54	Phosphorylation	RKSERMESIDTKRQK HHHHHHHHCCCCCCC	19.20	28432305
57	Phosphorylation	ERMESIDTKRQKPSI HHHHHCCCCCCCCCH	26.85	25575281
61	Acetylation	SIDTKRQKPSIHSRQ HCCCCCCCCCHHHHH	44.77	22902405
72	Acetylation	HSRQLISKPLSSSVS HHHHHHCCCCCCCCC	42.88	22902405
75	Phosphorylation	QLISKPLSSSVSNNK HHHCCCCCCCCCCCC	29.15	27097102
76	Phosphorylation	LISKPLSSSVSNNKR HHCCCCCCCCCCCCC	42.30	27097102
77	Phosphorylation	ISKPLSSSVSNNKRI HCCCCCCCCCCCCCE	26.62	27097102
79	Phosphorylation	KPLSSSVSNNKRIVS CCCCCCCCCCCCEEE	36.31	27097102
82	Acetylation	SSSVSNNKRIVSTKG CCCCCCCCCEEECCC	47.99	22902405
90	Acetylation	RIVSTKGKSVTEYKN CEEECCCCCHHHHCC	43.22	22902405
118	Phosphorylation	ADRKIRLSSSSSREP HHHCCCCCCCCCCCC	20.51	27097102
119	Phosphorylation	DRKIRLSSSSSREPY HHCCCCCCCCCCCCC	38.54	27097102
120	Phosphorylation	RKIRLSSSSSREPYK HCCCCCCCCCCCCCC	29.02	27097102
121	Phosphorylation	KIRLSSSSSREPYKS CCCCCCCCCCCCCCC	35.05	27097102
122	Phosphorylation	IRLSSSSSREPYKSQ CCCCCCCCCCCCCCC	42.48	27097102
146	Phosphorylation	DSERRAKSPTPDGSE HHHHHCCCCCCCHHH	32.78	29779826
148	Phosphorylation	ERRAKSPTPDGSERI HHHCCCCCCCHHHCC	40.89	27097102
152	Phosphorylation	KSPTPDGSERIGLEV CCCCCCHHHCCCHHH	30.96	27097102
278	Phosphorylation	SEASDSGSESVSFTD HHCCCCCCCCEEECC	30.56	21630457
311 (in isoform 2)	Phosphorylation	-	16.05	28689409
311	Phosphorylation	RKRARGISPIVFDRS HHHHCCCCCEEECCC	16.05	23712012
318 (in isoform 2)	Phosphorylation	-	44.89	28432305
318	Phosphorylation	SPIVFDRSGSSASES CCEEECCCCCCCCCC	44.89	16641100
320 (in isoform 2)	Phosphorylation	-	24.79	28432305
320	Phosphorylation	IVFDRSGSSASESYA EEECCCCCCCCCCCC	24.79	16641100
321 (in isoform 2)	Phosphorylation	-	39.06	28432305
321	Phosphorylation	VFDRSGSSASESYAG EECCCCCCCCCCCCC	39.06	28432305
323 (in isoform 2)	Phosphorylation	-	29.08	28432305
323	Phosphorylation	DRSGSSASESYAGSE CCCCCCCCCCCCCCH	29.08	28432305
325 (in isoform 2)	Phosphorylation	-	20.14	28432305
325	Phosphorylation	SGSSASESYAGSEKK CCCCCCCCCCCCHHH	20.14	28432305
326	Phosphorylation	GSSASESYAGSEKKH CCCCCCCCCCCHHHH	15.78	16641100
326 (in isoform 2)	Phosphorylation	-	15.78	28432305
329	Phosphorylation	ASESYAGSEKKHEKL CCCCCCCCHHHHHHH	37.76	22673903
330 (in isoform 2)	Phosphorylation	-	66.27	28432305
372	Phosphorylation	SNNHENVSLAKAKGV CCCCCCEEEEEECCC	33.90	23984901
381	Phosphorylation	AKAKGVWSTLPVNEK EEECCCEECCCCCHH	20.05	23984901
382	Phosphorylation	KAKGVWSTLPVNEKK EECCCEECCCCCHHH	21.26	23984901
419	Phosphorylation	FQGFARLSSESHHGG CCCEEECCCCCCCCC	26.89	27097102
420	Phosphorylation	QGFARLSSESHHGGS CCEEECCCCCCCCCC	47.94	27097102
422	Phosphorylation	FARLSSESHHGGSPI EEECCCCCCCCCCCC	23.80	27097102
427	Phosphorylation	SESHHGGSPIHWVLP CCCCCCCCCCEEEEE	25.85	27097102
438	Phosphorylation	WVLPAGMSAKMLGGV EEEECCCCHHHHCCE	24.66	25575281
518	Phosphorylation	RHKRRMHSQPRSRGR HHHHHHCCCCCCCCC	32.32	21630457
543	Phosphorylation	GRRRPEDYDIHNSRK CCCCCCCCCCCCCCC	18.35	-
548	Phosphorylation	EDYDIHNSRKKPRID CCCCCCCCCCCCCCC	31.17	-
588	Phosphorylation	LIPNRRFSGVRRDVF CCCCCCCCCCCCCEE	34.27	22673903
599	Phosphorylation	RDVFLNGSYNDYVRE CCEECCCCHHHHHHH	21.49	23984901

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of YTDC1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of YTDC1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of YTDC1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of YTDC1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.