| UniProt ID | IRF9_MOUSE | |
|---|---|---|
| UniProt AC | Q61179 | |
| Protein Name | Interferon regulatory factor 9 | |
| Gene Name | Irf9 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 399 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Transcription factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.. | |
| Protein Sequence | MASGKVRCTRKLRSWIVEQVESGHFPGVCWDDAAKTMFRIPWKHAGKQDFREDQDAAIFKAWALFKEKHKDGDIGHPAVWKTRLRCALNKSSEFEEVPERGRMDVAEPYKVYRILPAGTLPNQPRNQKSPCKRSISCVSPEREENMENGRTNGVVNHSDSGSNIGGGGNGSNRSDSNSNCNSELEEGAGTTEATIREDPVFLEHQLPLNSDYSLLLTFIYGGRVVGKTQVHSLDCRLVAERSDSESSMEQVEFPKPDPLEPTQHLLNQLDRGVLVASNSRGLFVQRLCPIPISWNAPEAPPGPGPHLLPSNKCVELFKTTYFCRDLAQYFQGQGPPPKFQATLHFWEESPGSSHSQENLITVQMEQAFARHLLEKIPEEEKAALFLLQHTEQSPSALGH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 129 | Phosphorylation | NQPRNQKSPCKRSIS CCCCCCCCCCCCCCC | 26.26 | 25266776 | |
| 134 | Phosphorylation | QKSPCKRSISCVSPE CCCCCCCCCCCCCCC | 12.35 | 30635358 | |
| 136 | Phosphorylation | SPCKRSISCVSPERE CCCCCCCCCCCCCHH | 15.09 | 19060867 | |
| 139 | Phosphorylation | KRSISCVSPEREENM CCCCCCCCCCHHHHC | 25.93 | 25263469 | |
| 151 | Phosphorylation | ENMENGRTNGVVNHS HHCCCCCCCCCEECC | 37.41 | - | |
| 158 | Phosphorylation | TNGVVNHSDSGSNIG CCCCEECCCCCCCCC | 28.41 | 28285833 | |
| 160 | Phosphorylation | GVVNHSDSGSNIGGG CCEECCCCCCCCCCC | 47.32 | 28285833 | |
| 182 | Phosphorylation | DSNSNCNSELEEGAG CCCCCCCHHHHCCCC | 45.84 | 26525534 | |
| 202 | Phosphorylation | IREDPVFLEHQLPLN ECCCCCEEEECCCCC | 6.13 | 24719451 | |
| 246 | Phosphorylation | AERSDSESSMEQVEF EECCCCCCHHCCCCC | 38.65 | 28285833 | |
| 247 | Phosphorylation | ERSDSESSMEQVEFP ECCCCCCHHCCCCCC | 23.45 | 28285833 | |
| 390 | Phosphorylation | ALFLLQHTEQSPSAL HHHHHHHHCCCCCCC | 23.82 | 28833060 | |
| 393 | Phosphorylation | LLQHTEQSPSALGH- HHHHHCCCCCCCCC- | 18.00 | 22942356 | |
| 395 | Phosphorylation | QHTEQSPSALGH--- HHHCCCCCCCCC--- | 41.18 | 28833060 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of IRF9_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of IRF9_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of IRF9_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| PO2F1_MOUSE | Pou2f1 | physical | 20211142 | |
| SOX6_MOUSE | Sox6 | physical | 20211142 | |
| MIXL1_MOUSE | Mixl1 | physical | 20211142 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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