SOX6_MOUSE - dbPTM
SOX6_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SOX6_MOUSE
UniProt AC P40645
Protein Name Transcription factor SOX-6
Gene Name Sox6
Organism Mus musculus (Mouse).
Sequence Length 827
Subcellular Localization Nucleus .
Protein Description Transcriptional activator. Binds specifically to the DNA sequence 5'-AACAAT-3'. Plays a key role in several developmental processes, including neurogenesis and skeleton formation..
Protein Sequence MSSKQATSPFACTADGEEAMTQDLTSREKEEGSDQHPASHLPLHPIMHNKPHSEELPTLVSTIQQDADWDSVLSSQQRMESENNKLCSLYSFRNTSTSPHKPDEGSREREIMNSVTFGTPERRKGSLADVVDTLKQKKLEEMTRTEQEDSSCMEKLLSKDWKEKMERLNTSELLGEIKGTPESLAEKERQLSTMITQLISLREQLLAAHDEQKKLAASQIEKQRQQMDLARQQQEQIARQQQQLLQQQHKINLLQQQIQVQGHMPPLMIPIFPHDQRTLAAAAAAQQGFLFPPGITYKPGDNYPVQFIPSTMAAAAASGLSPLQLQKGHVSHPQINPRLKGISDRFGRNLDPSEHGGGHSYNHRQIEQLYAAQLASMQVSPGAKMPSTPQPPNSAGAVSPTGIKNEKRGTSPVTQVKDETTAQPLNLSSRPKTAEPVKSPTSPTQNLFPASKTSPVNLPNKSSIPSPIGGSLGRGSSLDILSSLNSPALFGDQDTVMKAIQEARKMREQIQREQQQQPHGVDGKLSSMNNMGLSNCRTEKERTRFENLGPQLTGKSSEDGKLGPGVIDLTRPEDAEGSKAMNGSAAKLQQYYCWPTGGATVAEARVYRDARGRASSEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMSNQEKQPYYEEQARLSKIHLEKYPNYKYKPRPKRTCIVDGKKLRIGEYKQLMRSRRQEMRQFFTVGQQPQMPITTGTGVVYPGAITMATTTPSPQMTSDCSSTSASPEPSLPVIQSTYGMKMDGASLAGNDMINGEDEMEAYDDYEDDPKSDYSSENEAPEPVSAN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
8PhosphorylationMSSKQATSPFACTAD
CCCCCCCCCCCCCCC		22.4923527152
96PhosphorylationLYSFRNTSTSPHKPD
EEEEECCCCCCCCCC		30.3622817900
97PhosphorylationYSFRNTSTSPHKPDE
EEEECCCCCCCCCCC		44.2119367708
98PhosphorylationSFRNTSTSPHKPDEG
EEECCCCCCCCCCCC		25.4426824392
119PhosphorylationMNSVTFGTPERRKGS
HHHCCCCCCCCCCCC		20.1323527152
126PhosphorylationTPERRKGSLADVVDT
CCCCCCCCHHHHHHH		24.3426824392
143PhosphorylationQKKLEEMTRTEQEDS
HHHHHHHHCHHHHCH		37.4122324799
145PhosphorylationKLEEMTRTEQEDSSC
HHHHHHCHHHHCHHH		32.6222324799
150PhosphorylationTRTEQEDSSCMEKLL
HCHHHHCHHHHHHHH		25.3722324799
151PhosphorylationRTEQEDSSCMEKLLS
CHHHHCHHHHHHHHC		29.7922324799
155AcetylationEDSSCMEKLLSKDWK
HCHHHHHHHHCHHHH		28.0430987187
159AcetylationCMEKLLSKDWKEKME
HHHHHHCHHHHHHHH		68.5230795953
164AcetylationLSKDWKEKMERLNTS
HCHHHHHHHHHCCHH		42.1930988399
343PhosphorylationNPRLKGISDRFGRNL
CHHHCCCHHHCCCCC		31.2522817900
376PhosphorylationLYAAQLASMQVSPGA
HHHHHHHHCCCCCCC		20.5228285833
380PhosphorylationQLASMQVSPGAKMPS
HHHHCCCCCCCCCCC		10.7528285833
387PhosphorylationSPGAKMPSTPQPPNS
CCCCCCCCCCCCCCC		49.5821082442
388PhosphorylationPGAKMPSTPQPPNSA
CCCCCCCCCCCCCCC		21.7721183079
399PhosphorylationPNSAGAVSPTGIKNE
CCCCCCCCCCCCCCC		19.0626824392
401PhosphorylationSAGAVSPTGIKNEKR
CCCCCCCCCCCCCCC		43.9926160508
410PhosphorylationIKNEKRGTSPVTQVK
CCCCCCCCCCCCCCC		33.6125521595
411PhosphorylationKNEKRGTSPVTQVKD
CCCCCCCCCCCCCCC		21.8726824392
414PhosphorylationKRGTSPVTQVKDETT
CCCCCCCCCCCCCCC		30.9129472430
433PhosphorylationNLSSRPKTAEPVKSP
CCCCCCCCCCCCCCC		38.6522817900
439PhosphorylationKTAEPVKSPTSPTQN
CCCCCCCCCCCCCCC		33.3721082442
441PhosphorylationAEPVKSPTSPTQNLF
CCCCCCCCCCCCCCC		55.2019060867
442PhosphorylationEPVKSPTSPTQNLFP
CCCCCCCCCCCCCCC		29.3626824392
444PhosphorylationVKSPTSPTQNLFPAS
CCCCCCCCCCCCCCC		29.8325521595
451PhosphorylationTQNLFPASKTSPVNL
CCCCCCCCCCCCCCC		36.3825293948
453PhosphorylationNLFPASKTSPVNLPN
CCCCCCCCCCCCCCC		35.4525293948
454PhosphorylationLFPASKTSPVNLPNK
CCCCCCCCCCCCCCC		30.5025521595
462PhosphorylationPVNLPNKSSIPSPIG
CCCCCCCCCCCCCCC		39.8923527152
463PhosphorylationVNLPNKSSIPSPIGG
CCCCCCCCCCCCCCC		39.8829472430
466PhosphorylationPNKSSIPSPIGGSLG
CCCCCCCCCCCCCCC		27.7223527152
471PhosphorylationIPSPIGGSLGRGSSL
CCCCCCCCCCCCCHH		23.5729472430
553PhosphorylationENLGPQLTGKSSEDG
HHCCCCCCCCCCCCC		37.0026643407
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
119TPhosphorylationKinaseCDK5Q03114
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SOX6_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SOX6_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TOX3_MOUSETox3physical
20211142
DAZP2_MOUSEDazap2physical
14530442
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SOX6_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-126, AND MASSSPECTROMETRY.

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