dbPTM

IMPL2_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	IMPL2_DROME
UniProt AC	Q09024
Protein Name	Neural/ectodermal development factor IMP-L2
Gene Name	ImpL2
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	267
Subcellular Localization	Secreted, extracellular space.
Protein Description	Essential developmental role during embryogenesis, in particular the normal development of the nervous system. May be involved in some aspect of cell adhesion..
Protein Sequence	MEAKMNLHVCALALLLFGSIATVRGRAVDLVDDSNDVDNSIEAEEEKPRNRAFEADWLKFTKTPPTKLQQADGATIEIVCEMMGSQVPSIQWVVGHLPRSELDDLDSNQVAEEAPSAIVRVRSSHIIDHVLSEARTYTCVGRTGSKTIYASTVVHPPRSSRLTPEKTYPGAQKPRIIYTEKTHLDLMGSNIQLPCRVHARPRAEITWLNNENKEIVQGHRHRVLANGDLLISEIKWEDMGNYKCIARNVVGKDTADTFVYPVLNEED

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34	Phosphorylation	AVDLVDDSNDVDNSI EEECCCCCCCCCCCC	30.39	25749252
40	Phosphorylation	DSNDVDNSIEAEEEK CCCCCCCCCHHHHHC	19.83	25749252
100	Phosphorylation	VVGHLPRSELDDLDS EEECCCHHHHCCCCC	40.34	21082442
107	Phosphorylation	SELDDLDSNQVAEEA HHHCCCCCCHHHHHC	36.14	25749252

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of IMPL2_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of IMPL2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of IMPL2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
INSL2_DROME	Ilp2	physical	22036573
INSL2_DROME	Ilp2	genetic	18412985
INSL5_DROME	Ilp5	physical	21108726
INSL5_DROME	Ilp5	physical	20974844
IMPL2_DROME	ImpL2	physical	23827685
INSL2_DROME	Ilp2	physical	21108726

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of IMPL2_DROME

Related Literatures of Post-Translational Modification