IL1R1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IL1R1_MOUSE
• UniProt AC: P13504
• Protein Name: Interleukin-1 receptor type 1
• Gene Name: Il1r1
• Organism: Mus musculus (Mouse).
• Sequence Length: 576
• Subcellular Localization: Membrane; Single-pass type I membrane protein. Cell membrane . Secreted.
• Protein Description: Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (By similarity).; Isoform 2: Unable to mediate canonical IL-1 signaling. Cooperates with IL1RAP isoform 3 to mediate IL1B-induced neuronal activity including IL1B-potentiated NMDA-induced calcium influx mediated by Akt kinase activation..
• Protein Sequence: MENMKVLLGLICLMVPLLSLEIDVCTEYPNQIVLFLSVNEIDIRKCPLTPNKMHGDTIIWYKNDSKTPISADRDSRIHQQNEHLWFVPAKVEDSGYYYCIVRNSTYCLKTKVTVTVLENDPGLCYSTQATFPQRLHIAGDGSLVCPYVSYFKDENNELPEVQWYKNCKPLLLDNVSFFGVKDKLLVRNVAEEHRGDYICRMSYTFRGKQYPVTRVIQFITIDENKRDRPVILSPRNETIEADPGSMIQLICNVTGQFSDLVYWKWNGSEIEWNDPFLAEDYQFVEHPSTKRKYTLITTLNISEVKSQFYRYPFICVVKNTNIFESAHVQLIYPVPDFKNYLIGGFIILTATIVCCVCIYKVFKVDIVLWYRDSCSGFLPSKASDGKTYDAYILYPKTLGEGSFSDLDTFVFKLLPEVLEGQFGYKLFIYGRDDYVGEDTIEVTNENVKKSRRLIIILVRDMGGFSWLGQSSEEQIAIYNALIQEGIKIVLLELEKIQDYEKMPDSIQFIKQKHGVICWSGDFQERPQSAKTRFWKNLRYQMPAQRRSPLSKHRLLTLDPVRDTKEKLPAATHLPLG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
63	N-linked_Glycosylation	DTIIWYKNDSKTPIS CEEEEEECCCCCCCC	42.99	-
103	N-linked_Glycosylation	YYYCIVRNSTYCLKT EEEEEEECCEEEEEE	28.01	-
147	Phosphorylation	DGSLVCPYVSYFKDE CCCEECCEEEEECCC	9.26	28576409
150	Phosphorylation	LVCPYVSYFKDENNE EECCEEEEECCCCCC	12.47	28576409
174	N-linked_Glycosylation	CKPLLLDNVSFFGVK CCEEEECCCEEECCC	31.16	-
236	N-linked_Glycosylation	PVILSPRNETIEADP CEEECCCCCCEECCC	54.90	-
252	N-linked_Glycosylation	SMIQLICNVTGQFSD CEEEHHHHHHCCCCC	27.65	-
266	N-linked_Glycosylation	DLVYWKWNGSEIEWN CEEEEEECCCCCEEC	40.15	-
293	Phosphorylation	HPSTKRKYTLITTLN CCCCCCEEEEEEEEE	15.71	30635358
294	Phosphorylation	PSTKRKYTLITTLNI CCCCCEEEEEEEEEH	18.08	30635358
297	Phosphorylation	KRKYTLITTLNISEV CCEEEEEEEEEHHHH	28.48	30635358
298	Phosphorylation	RKYTLITTLNISEVK CEEEEEEEEEHHHHH	15.71	30635358
300	N-linked_Glycosylation	YTLITTLNISEVKSQ EEEEEEEEHHHHHHH	33.38	-
302	Phosphorylation	LITTLNISEVKSQFY EEEEEEHHHHHHHHH	34.95	30635358
402	Phosphorylation	PKTLGEGSFSDLDTF CCCCCCCCCHHHHHH	19.78	25338131
499	Phosphorylation	ELEKIQDYEKMPDSI EHHHHCCHHHCCCHH	10.90	-
501	Ubiquitination	EKIQDYEKMPDSIQF HHHCCHHHCCCHHHH	49.88	22790023
505	Phosphorylation	DYEKMPDSIQFIKQK CHHHCCCHHHHHHHH	16.66	23984901
547	Phosphorylation	QMPAQRRSPLSKHRL CCCCCCCCCCCCCCE	32.17	22324799
550	Phosphorylation	AQRRSPLSKHRLLTL CCCCCCCCCCCEEEC	29.78	22324799
556	Phosphorylation	LSKHRLLTLDPVRDT CCCCCEEECCCCCCC	33.43	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
556	T	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
556	T	Phosphorylation	Kinase	PKC	-	Uniprot
556	T	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IL1R1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IL1R1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IRAK4_MOUSE	Irak4	physical	17507369
IL1A_MOUSE	Il1a	physical	17507369
IL1AP_MOUSE	Il1rap	physical	17507369
MYD88_MOUSE	Myd88	physical	17507369
IRAK1_MOUSE	Irak1	physical	17507369
IRAK1_HUMAN	IRAK1	physical	9426216
IRAK4_MOUSE	Irak4	physical	15292196

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phorbol ester induces phosphorylation of the 80 kilodalton murineinterleukin 1 receptor at a single threonine residue.";
Bird T.A., Woodward A., Jackson J.L., Dower S.K., Sims J.E.;
Biochem. Biophys. Res. Commun. 177:61-67(1991).
Cited for: PHOSPHORYLATION AT THR-556.
PubMed: 1828344