dbPTM

IL1A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	IL1A_MOUSE
UniProt AC	P01582
Protein Name	Interleukin-1 alpha
Gene Name	Il1a
Organism	Mus musculus (Mouse).
Sequence Length	270
Subcellular Localization	Secreted. The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.
Protein Description	Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells..
Protein Sequence	MAKVPDLFEDLKNCYSENEDYSSAIDHLSLNQKSFYDASYGSLHETCTDQFVSLRTSETSKMSNFTFKESRVTVSATSSNGKILKKRRLSFSETFTEDDLQSITHDLEETIQPRSAPYTYQSDLRYKLMKLVRQKFVMNDSLNQTIYQDVDKHYLSTTWLNDLQQEVKFDMYAYSSGGDDSKYPVTLKISDSQLFVSAQGEDQPVLLKELPETPKLITGSETDLIFFWKSINSKNYFTSAAYPELFIATKEQSRVHLARGLPSMTDFQIS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	FEDLKNCYSENEDYS HHHHHHHCCCCCCHH	28.54	30635358
16	Phosphorylation	EDLKNCYSENEDYSS HHHHHHCCCCCCHHH	35.82	22942356
22	Phosphorylation	YSENEDYSSAIDHLS CCCCCCHHHHHHHHC	26.14	22942356
64	N-linked_Glycosylation	SETSKMSNFTFKESR CCCCCCCCCEEEECE	36.16	-
90	Phosphorylation	ILKKRRLSFSETFTE EEEEEEEECCCCCCH	25.55	3126184
92	Phosphorylation	KKRRLSFSETFTEDD EEEEEECCCCCCHHH	32.14	24719451
115	Phosphorylation	EETIQPRSAPYTYQS HHHCCCCCCCCCCCH	40.03	22942356
139	N-linked_Glycosylation	VRQKFVMNDSLNQTI HHHHHHCCCCCCCCH	30.34	-
143	N-linked_Glycosylation	FVMNDSLNQTIYQDV HHCCCCCCCCHHHCH	40.68	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of IL1A_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of IL1A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of IL1A_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of IL1A_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of IL1A_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"The precursor of interleukin-1 alpha is phosphorylated at residueserine 90."; Beuscher H.U., Nickells M.W., Colten H.R.; J. Biol. Chem. 263:4023-4028(1988). Cited for: PHOSPHORYLATION AT SER-90.	3126184 [Abstract]