IINMP_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IINMP_SCHPO
• UniProt AC: O13681
• Protein Name: Integral inner nuclear membrane protein ima1
• Gene Name: IMA1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 615
• Subcellular Localization: Nucleus inner membrane ; Multi-pass membrane protein .
• Protein Description: Inner nuclear membrane protein that specifically binds to heterochromatic regions and promotes the tethering of centromeric DNA to the SUN-KASH complex. Couples centromeres to the nuclear envelope, thus contributing to their association with the microtubule organizing center attachment site and to the positioning of the nucleus at the cell center by microtubules..
• Protein Sequence: MESSRLFTLGLGNSDDGLKSTFGDKTVTCFYCNKKKEKIRDGTSTWTCSICEATNHIDEKGDILDYRPPTPTQDKGVGPFYAIRDFPSSSSFQSPFCEKCQMNQLIVNRMLADYLPDSSHPDYQAYEKALPEYKKSIEEKFPIVCSECYDSVQDQLDANDYEAKNQVLGYWLQKSKEQLNAKVPHHYPKASFVLWLLRGFGFSFFYLQSIVWHLYHSMIISLLPDGIRNLFLKAISYFLLDGSSSKIFYFNWLGFFVVFWNPYWYKMMDNPSWELFGRDQYIQCQALYLIIRLTCLYLLSCYESEILNLSSDTNLESDFLLRQIHAAFFFVTICFTWISISCLKPSPPPEVHLTGEILKPRKKRQESTSSVHRIGKESSDRKDGISGQNKLQQFATISILNNTNATSHLGNQSVRERAPEESPMTFLQKKMAALPTSSPVRPMLKPTLQLQNSPLSKLVPQEVGNKVNDSIHTTSNQPSKFSLNPSISLKGDNVIEKNLPFSVSTLKSTAKKDTGKAGDGQNREIQNEPVSLESHFSKSLALQNDPTEVIQVKNVLHRNRRNAKLLIAFTILFLVGLICGWRLNRFTMFIYYLCILVLATYYVMKHNFYPLRKVA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	FTLGLGNSDDGLKST EEECCCCCCCCCHHH		25720772
66	Phosphorylation	EKGDILDYRPPTPTQ CCCCCCCCCCCCCCC		21712547
70	Phosphorylation	ILDYRPPTPTQDKGV CCCCCCCCCCCCCCC		21712547
72	Phosphorylation	DYRPPTPTQDKGVGP CCCCCCCCCCCCCCC		24763107
367	Phosphorylation	PRKKRQESTSSVHRI CCCCCCCCCCCCHHC		21712547
368	Phosphorylation	RKKRQESTSSVHRIG CCCCCCCCCCCHHCC		21712547
369	Phosphorylation	KKRQESTSSVHRIGK CCCCCCCCCCHHCCC		24763107
370	Phosphorylation	KRQESTSSVHRIGKE CCCCCCCCCHHCCCC		24763107
422	Phosphorylation	RERAPEESPMTFLQK HHHCCCCCCCCHHHH		29996109
436	Phosphorylation	KKMAALPTSSPVRPM HHHHCCCCCCCCCCC		21712547
437	Phosphorylation	KMAALPTSSPVRPML HHHCCCCCCCCCCCC		21712547
438	Phosphorylation	MAALPTSSPVRPMLK HHCCCCCCCCCCCCC		24763107
447	Phosphorylation	VRPMLKPTLQLQNSP CCCCCCCEEECCCCC		21712547
453	Phosphorylation	PTLQLQNSPLSKLVP CEEECCCCCHHHHCC		24763107
456	Phosphorylation	QLQNSPLSKLVPQEV ECCCCCHHHHCCHHH		21712547
504	Phosphorylation	KNLPFSVSTLKSTAK CCCCCCHHHHHHHCC		25720772
505	Phosphorylation	NLPFSVSTLKSTAKK CCCCCHHHHHHHCCC		25720772
539	Phosphorylation	LESHFSKSLALQNDP HHHHHCHHHHCCCCC		25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IINMP_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IINMP_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IINMP_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MUG61_SCHPO	man1	genetic	21880100
LEM2_SCHPO	lem2	genetic	21880100
SAD1_SCHPO	sad1	physical	21880100
IINMP_SCHPO	ima1	physical	21880100
MUG61_SCHPO	man1	physical	21880100
LEM2_SCHPO	lem2	physical	21880100
IINMP_SCHPO	ima1	physical	26771498

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.