IBH1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IBH1_ARATH
• UniProt AC: Q9SKX1
• Protein Name: Transcription factor IBH1
• Gene Name: IBH1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 156
• Subcellular Localization: Nucleus .
• Protein Description: Atypical and probable non DNA-binding bHLH transcription factor that acts as transcriptional repressor that negatively regulates cell and organ elongation in response to gibberellin (GA) and brassinosteroid (BR) signaling. Is able to form heterodimer with BHLH49, thus inhibiting DNA binding of BHLH49, which is a transcriptional activator that regulates the expression of a subset of genes involved in cell expansion by binding to the G-box motif. Binds and inhibits HBI1, a positive regulator of cell elongation that directly binds to the promoters and activated the two expansin genes EXPA1 and EXPA8, encoding cell wall loosening enzymes. The ability of IBH1 to inhibit BHLH49 and HBI1 is counteracted by binding to the antagonist bHLH transcription factor PRE1, restoring the transcriptional activity of BHLH49 and HBI1 and resulting in induction of cell elongation. Functions redundantly with IBL1/BHLH159 in a regulation node known as the incoherent feed-forward loop (FFL). [PubMed: 24505057]
• Protein Sequence: MASADKLINTDVPEKDVFAFHFLQSLSNLRKQNPFDTPDQKNYRVRKIKKAAYVSMARAAGGSSRLWSRALLRRADKDDNKIVRFSRRKWKISSKRRRSNQRAPVVEEAAERLRNLVPGGGGMETSKLMEETAHYIKCLSMQVKVMQCLVDGLSPK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
55	Phosphorylation	IKKAAYVSMARAAGG HHHHHHHHHHHHCCC		24894044
63	Phosphorylation	MARAAGGSSRLWSRA HHHHCCCCHHHHHHH		24894044
125	Phosphorylation	PGGGGMETSKLMEET CCCCCHHHHHHHHHH		24243849
132	Phosphorylation	TSKLMEETAHYIKCL HHHHHHHHHHHHHHH		23776212
135	Phosphorylation	LMEETAHYIKCLSMQ HHHHHHHHHHHHHHH		23776212
140	Phosphorylation	AHYIKCLSMQVKVMQ HHHHHHHHHHHHHHH		23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IBH1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IBH1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IBH1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NAP1C_ARATH	NAP1;3	physical	21798944
BH078_ARATH	AT5G48560	physical	21798944
BEE2_ARATH	BEE2	physical	21798944
NAP1A_ARATH	NAP1;1	physical	21798944
BH063_ARATH	CIB1	physical	21798944

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.