I17RD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: I17RD_HUMAN
• UniProt AC: Q8NFM7
• Protein Name: Interleukin-17 receptor D
• Gene Name: IL17RD
• Organism: Homo sapiens (Human).
• Sequence Length: 739
• Subcellular Localization: Golgi apparatus membrane ; Single-pass type I membrane protein . Cell membrane ; Single-pass type I membrane protein . Predominantly associated with the Golgi apparatus and is partially translocated to the plasma membrane upon stimulation.; Isoform 4
• Protein Description: Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK. Mediates JNK activation and may be involved in apoptosis. Might have a role in the early stages of fate specification of GnRH-secreting neurons (By similarity)..
• Protein Sequence: MAPWLQLCSVFFTVNACLNGSQLAVAAGGSGRARGADTCGWRGVGPASRNSGLYNITFKYDNCTTYLNPVGKHVIADAQNITISQYACHDQVAVTILWSPGALGIEFLKGFRVILEELKSEGRQCQQLILKDPKQLNSSFKRTGMESQPFLNMKFETDYFVKVVPFPSIKNESNYHPFFFRTRACDLLLQPDNLACKPFWKPRNLNISQHGSDMQVSFDHAPHNFGFRFFYLHYKLKHEGPFKRKTCKQEQTTETTSCLLQNVSPGDYIIELVDDTNTTRKVMHYALKPVHSPWAGPIRAVAITVPLVVISAFATLFTVMCRKKQQENIYSHLDEESSESSTYTAALPRERLRPRPKVFLCYSSKDGQNHMNVVQCFAYFLQDFCGCEVALDLWEDFSLCREGQREWVIQKIHESQFIIVVCSKGMKYFVDKKNYKHKGGGRGSGKGELFLVAVSAIAEKLRQAKQSSSAALSKFIAVYFDYSCEGDVPGILDLSTKYRLMDNLPQLCSHLHSRDHGLQEPGQHTRQGSRRNYFRSKSGRSLYVAICNMHQFIDEEPDWFEKQFVPFHPPPLRYREPVLEKFDSGLVLNDVMCKPGPESDFCLKVEAAVLGATGPADSQHESQHGGLDQDGEARPALDGSAALQPLLHTVKAGSPSDMPRDSGIYDSSVPSSELSLPLMEGLSTDQTETSSLTESVSSSSGLGEEEPPALPSKLLSSGSCKADLGCRSYTDELHAVAPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	N-linked_Glycosylation	FTVNACLNGSQLAVA HHHHHHHCCCEEEEC	48.21	UniProtKB CARBOHYD
38	Phosphorylation	GRARGADTCGWRGVG CCCCCCCCCCCCCCC	16.63	29978859
48	Phosphorylation	WRGVGPASRNSGLYN CCCCCCCCCCCCCEE	34.82	29978859
51	Phosphorylation	VGPASRNSGLYNITF CCCCCCCCCCEEEEE	29.12	29978859
54	Phosphorylation	ASRNSGLYNITFKYD CCCCCCCEEEEEEEC	14.19	29978859
55	N-linked_Glycosylation	SRNSGLYNITFKYDN CCCCCCEEEEEEECC	31.69	UniProtKB CARBOHYD
57	Phosphorylation	NSGLYNITFKYDNCT CCCCEEEEEEECCEE	15.50	29978859
60	Phosphorylation	LYNITFKYDNCTTYL CEEEEEEECCEEEEE	14.27	29759185
62	N-linked_Glycosylation	NITFKYDNCTTYLNP EEEEEECCEEEEECC	23.19	UniProtKB CARBOHYD
66	Phosphorylation	KYDNCTTYLNPVGKH EECCEEEEECCCCCE	6.07	29759185
80	N-linked_Glycosylation	HVIADAQNITISQYA EEEECCCCEEEEEEC	34.78	UniProtKB CARBOHYD
137	N-linked_Glycosylation	LKDPKQLNSSFKRTG HCCHHHHCHHHHHCC	32.87	UniProtKB CARBOHYD
147	Phosphorylation	FKRTGMESQPFLNMK HHHCCCCCCCCCCCE	33.97	27251275
157	Phosphorylation	FLNMKFETDYFVKVV CCCCEEECCEEEEEE	38.85	27251275
159	Phosphorylation	NMKFETDYFVKVVPF CCEEECCEEEEEEEC	20.07	27251275
168	Phosphorylation	VKVVPFPSIKNESNY EEEEECCCCCCCCCC	46.72	29083192
171	N-linked_Glycosylation	VPFPSIKNESNYHPF EECCCCCCCCCCCCC	57.15	UniProtKB CARBOHYD
173	Phosphorylation	FPSIKNESNYHPFFF CCCCCCCCCCCCCEE	52.67	30266825
175	Phosphorylation	SIKNESNYHPFFFRT CCCCCCCCCCCEEEC	21.83	30266825
182	Phosphorylation	YHPFFFRTRACDLLL CCCCEEECCCHHHHC	19.91	30266825
206	N-linked_Glycosylation	FWKPRNLNISQHGSD CCCCCCCCCCCCCCC	35.10	UniProtKB CARBOHYD
268	Phosphorylation	QNVSPGDYIIELVDD CCCCCCCEEEEEECC	15.09	-
277	N-linked_Glycosylation	IELVDDTNTTRKVMH EEEECCCCCHHHHHH	46.58	UniProtKB CARBOHYD
304	Phosphorylation	PIRAVAITVPLVVIS CCHHEEEHHHHHHHH	13.31	-
415	Phosphorylation	VIQKIHESQFIIVVC HHHHHHHCCEEEEEE	19.07	-
423	Phosphorylation	QFIIVVCSKGMKYFV CEEEEEECCCCEEEE	22.19	-
435	Phosphorylation	YFVDKKNYKHKGGGR EEEECCCCCCCCCCC	24.29	22817900
467	Phosphorylation	KLRQAKQSSSAALSK HHHHHHHCCHHHHHH	26.08	-
529	Phosphorylation	GQHTRQGSRRNYFRS CCCCCCCCCCCCEEC	21.52	28165663
654	Phosphorylation	LHTVKAGSPSDMPRD HHHHCCCCCCCCCCC	26.53	27732954
656	Phosphorylation	TVKAGSPSDMPRDSG HHCCCCCCCCCCCCC	48.52	27732954
712	Phosphorylation	EEPPALPSKLLSSGS CCCCCCCHHHHCCCC	36.46	24719451
729	Phosphorylation	ADLGCRSYTDELHAV CCCCCCCCCCCEEEE	10.00	24173317
730	Phosphorylation	DLGCRSYTDELHAVA CCCCCCCCCCEEEEC	25.01	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of I17RD_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of I17RD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of I17RD_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
M3K7_HUMAN	MAP3K7	physical	23770285
FBW1A_HUMAN	BTRC	physical	28514442
FBW1B_HUMAN	FBXW11	physical	28514442
PTPRD_HUMAN	PTPRD	physical	28514442
TR19L_HUMAN	RELT	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 615267: Hypogonadotropic hypogonadism 18 with or without anosmia (HH18)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.