HXK4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HXK4_MOUSE
• UniProt AC: P52792
• Protein Name: Glucokinase
• Gene Name: Gck
• Organism: Mus musculus (Mouse).
• Sequence Length: 465
• Subcellular Localization: Cytoplasm . Nucleus . Under low glucose concentrations, GCK associates with GKRP and the inactive complex is recruited to the hepatocyte nucleus.
• Protein Description: Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage..
• Protein Sequence: MLDDRARMEATKKEKVEQILAEFQLQEEDLKKVMSRMQKEMDRGLKLETHQEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGNSGELDEFLLEYDRMVDESSVNPGQQLYEKIIGGKYMGELVRLVLLKLVEENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRRQILNILSTLGLRPSVADCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPNCEITFIESEEGSGRGAALVSAVACKKACMLGQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	Ubiquitination	KEMDRGLKLETHQEA HHHHHCCCCCCHHHH	47.29	22790023
56	Ubiquitination	THQEASVKMLPTYVR CHHHHHHHCCCEEEC	32.02	22790023
65	Phosphorylation	LPTYVRSTPEGSEVG CCEEECCCCCCCCCC	18.13	23567750
69	Phosphorylation	VRSTPEGSEVGDFLS ECCCCCCCCCCCEEE	27.70	23567750
102	Ubiquitination	EAGQWSVKTKHQMYS CCCEEEEEECEECEE	46.47	22790023
161	Ubiquitination	VRHEDIDKGILLNWT ECHHHCCCCEEEEEC	48.46	22790023
169	Ubiquitination	GILLNWTKGFKASGA CEEEEECCCCCCCCC	54.70	22790023
172	Malonylation	LNWTKGFKASGAEGN EEECCCCCCCCCCCC	50.76	26320211
172	Ubiquitination	LNWTKGFKASGAEGN EEECCCCCCCCCCCC	50.76	-
291	Ubiquitination	PGQQLYEKIIGGKYM CCHHHHHHHHCCCHH	26.52	22790023
296	Malonylation	YEKIIGGKYMGELVR HHHHHCCCHHHHHHH	27.18	26320211
296	Acetylation	YEKIIGGKYMGELVR HHHHHCCCHHHHHHH	27.18	23954790
296	Ubiquitination	YEKIIGGKYMGELVR HHHHHCCCHHHHHHH	27.18	-
364	S-palmitoylation	LRPSVADCDIVRRAC CCCCHHHCHHHHHHH	2.51	28526873
382	S-palmitoylation	STRAAHMCSAGLAGV HHHHHHHHHHHHHHH	1.48	26165157
411	Phosphorylation	ITVGVDGSVYKLHPS EEECCCCCEEECCHH	20.15	30352176
414	Ubiquitination	GVDGSVYKLHPSFKE CCCCCEEECCHHHHH	37.86	22790023
420	Ubiquitination	YKLHPSFKERFHASV EECCHHHHHHHHHHH	52.93	22790023
458	Ubiquitination	LVSAVACKKACMLGQ HHHHHHHHHHHHCCC	33.40	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HXK4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HXK4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HXK4_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BAD_MOUSE	Bad	physical	12931191
WASF1_MOUSE	Wasf1	physical	12931191
KAPCA_MOUSE	Prkaca	physical	12931191

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.