| UniProt ID | HCN1_HUMAN | |
|---|---|---|
| UniProt AC | O60741 | |
| Protein Name | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | |
| Gene Name | HCN1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 890 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein . |
|
| Protein Description | Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. [PubMed: 28086084 Contributes to the native pacemaker currents in heart (If) and in neurons (Ih May mediate responses to sour stimuli.] | |
| Protein Sequence | MEGGGKPNSSSNSRDDGNSVFPAKASATGAGPAAAEKRLGTPPGGGGAGAKEHGNSVCFKVDGGGGGGGGGGGGEEPAGGFEDAEGPRRQYGFMQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGMDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQAIAPINYPQMTTLNSTSSTTTPTSRMRTQSPPVYTATSLSHSNLHSPSPSTQTPQPSAILSPCSYTTAVCSPPVQSPLAARTFHYASPTASQLSLMQQQPQQQVQQSQPPQTQPQQPSPQPQTPGSSTPKNEVHKSTQALHNTNLTREVRPLSASQPSLPHEVSTLISRPHPTVGESLASIPQPVTAVPGTGLQAGGRSTVPQRVTLFRQMSSGAIPPNRGVPPAPPPPAAALPRESSSVLNTDPDAEKPRFASNL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 26 | Phosphorylation | SVFPAKASATGAGPA CCCCCCCCCCCCCHH | 26.17 | 20068231 | |
| 28 | Phosphorylation | FPAKASATGAGPAAA CCCCCCCCCCCHHHH | 25.68 | 20068231 | |
| 41 | Phosphorylation | AAEKRLGTPPGGGGA HHHHHHCCCCCCCCC | 30.79 | 20068231 | |
| 91 | Phosphorylation | AEGPRRQYGFMQRQF CCCHHHHHHHHHHHH | 15.54 | 29978859 | |
| 99 | Phosphorylation | GFMQRQFTSMLQPGV HHHHHHHHHHHCCCC | 12.61 | 30576142 | |
| 100 | Phosphorylation | FMQRQFTSMLQPGVN HHHHHHHHHHCCCCC | 20.84 | 29978859 | |
| 110 | Phosphorylation | QPGVNKFSLRMFGSQ CCCCCHHHHHHHCCH | 19.37 | 25394399 | |
| 116 | Phosphorylation | FSLRMFGSQKAVEKE HHHHHHCCHHHHHHH | 19.76 | 30576142 | |
| 217 | Phosphorylation | PKVIKMNYLKSWFVV HHHEEHHHCCHHHHH | 16.41 | - | |
| 338 | N-linked_Glycosylation | VSLNEMVNDSWGKQY EEHHHHHCCCCHHHH | 35.97 | UniProtKB CARBOHYD | |
| 407 | Phosphorylation | LDSSRRQYQEKYKQV HHHHHHHHHHHHHHH | 19.48 | - | |
| 411 | Phosphorylation | RRQYQEKYKQVEQYM HHHHHHHHHHHHHHH | 13.10 | 17977941 | |
| 417 | Phosphorylation | KYKQVEQYMSFHKLP HHHHHHHHHHHCCCC | 4.92 | - | |
| 513 | Phosphorylation | GAVGKKMYFIQHGVA CCCCCEEEEEECCCE | 13.35 | 22496350 | |
| 623 | Ubiquitination | NQENEILKQIVKHDR CHHHHHHHHHHHCCH | 43.57 | - | |
| 645 | O-linked_Glycosylation | PINYPQMTTLNSTSS CCCCCCCEECCCCCC | 23.92 | 28657654 | |
| 700 | O-linked_Glycosylation | ILSPCSYTTAVCSPP EECCCCCEEECCCCC | 7.62 | 28657654 | |
| 807 | O-linked_Glycosylation | LISRPHPTVGESLAS HHCCCCCCCCHHHHC | 37.80 | 28657654 | |
| 846 | Phosphorylation | VTLFRQMSSGAIPPN HHHHHHHCCCCCCCC | 19.79 | - | |
| 847 | Phosphorylation | TLFRQMSSGAIPPNR HHHHHHCCCCCCCCC | 27.23 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HCN1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HCN1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HCN1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| HCN2_HUMAN | HCN2 | physical | 12928435 | |
| HCN3_HUMAN | HCN3 | physical | 12928435 | |
| HCN4_HUMAN | HCN4 | physical | 12928435 | |
| HCN1_HUMAN | HCN1 | physical | 12034718 | |
| HCN2_HUMAN | HCN2 | physical | 12034718 | |
| NED4L_HUMAN | NEDD4L | physical | 24451387 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 615871 | Epileptic encephalopathy, early infantile, 24 (EIEE24) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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