HCN3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HCN3_HUMAN
• UniProt AC: Q9P1Z3
• Protein Name: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3
• Gene Name: HCN3
• Organism: Homo sapiens (Human).
• Sequence Length: 774
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Hyperpolarization-activated potassium channel. May also facilitate the permeation of sodium ions..
• Protein Sequence: MEAEQRPAAGASEGATPGLEAVPPVAPPPATAASGPIPKSGPEPKRRHLGTLLQPTVNKFSLRVFGSHKAVEIEQERVKSAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKEENSPPWIVFNVLSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDYIFLVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVSINHMVNHSWGRQYSHALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQGKMFDEESILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDTRLTDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLLRIGKKNSILQRKRSEPSPGSSGGIMEQHLVQHDRDMARGVRGRAPSTGAQLSGKPVLWEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLLARSAWRSAGSPASPLVPVRAGPWASTSRLPAPPARTLHASLSRAGRSQVSLLGPPPGGGGRRLGPRGRPLSASQPSLPQRATGDGSPGRKGSGSERLPPSGLLAKPPRTAQPPRPPVPEPATPRGLQLSANM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
61	Phosphorylation	QPTVNKFSLRVFGSH CCCCCCCCEEHHCCC	19.51	25394399
69	Ubiquitination	LRVFGSHKAVEIEQE EEHHCCCCCEEEEHH	56.69	-
166	Phosphorylation	LAPRAIRTRYLRTWF ECCHHHHHHHHHHHH	19.97	26657352
179	Phosphorylation	WFLVDLISSIPVDYI HHHHHHHHHCCCEEE	29.52	26657352
180	Phosphorylation	FLVDLISSIPVDYIF HHHHHHHHCCCEEEE	24.74	26657352
291	N-linked_Glycosylation	VSINHMVNHSWGRQY EEHHHHHCCCCHHHH	18.85	UniProtKB CARBOHYD
360	Phosphorylation	LDSSRRQYQEKYKQV HHHHHHHHHHHHHHH	19.48	-
364	Phosphorylation	RRQYQEKYKQVEQYM HHHHHHHHHHHHHHH	13.10	17977941
370	Phosphorylation	KYKQVEQYMSFHKLP HHHHHHHHHHHCCCC	4.92	-
387	Phosphorylation	TRQRIHEYYEHRYQG HHHHHHHHHHHHHCC	10.45	-
515	Phosphorylation	ADTYCRLYSLSVDHF CCCHHHHEEECHHHH	6.55	22210691
516	Phosphorylation	DTYCRLYSLSVDHFN CCHHHHEEECHHHHH	20.82	22210691
518	Phosphorylation	YCRLYSLSVDHFNAV HHHHEEECHHHHHHH	21.40	22210691
552	Phosphorylation	LRIGKKNSILQRKRS HHHCHHCCHHHHCCC	33.29	26074081
559	Phosphorylation	SILQRKRSEPSPGSS CHHHHCCCCCCCCCC	57.82	26074081
562	Phosphorylation	QRKRSEPSPGSSGGI HHCCCCCCCCCCCCH	37.53	26074081
565	Phosphorylation	RSEPSPGSSGGIMEQ CCCCCCCCCCCHHHH	29.24	26074081
566	Phosphorylation	SEPSPGSSGGIMEQH CCCCCCCCCCHHHHH	47.13	26074081
634	Phosphorylation	QRGPLPLSPDSPATL CCCCCCCCCCCHHHH	25.40	-
655	Phosphorylation	RSAGSPASPLVPVRA HHCCCCCCCCCCCCC	23.35	32142685
678	Phosphorylation	LPAPPARTLHASLSR CCCCCHHHHHHHHHH	25.63	-
682	Phosphorylation	PARTLHASLSRAGRS CHHHHHHHHHHCCCC	19.01	27174698
684	Phosphorylation	RTLHASLSRAGRSQV HHHHHHHHHCCCCCE	20.00	27174698
689	Phosphorylation	SLSRAGRSQVSLLGP HHHHCCCCCEEECCC	33.73	32142685

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HCN3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HCN3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HCN3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of HCN3_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.