dbPTM

GUN25_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GUN25_ARATH
UniProt AC	Q38890
Protein Name	Endoglucanase 25
Gene Name	KOR
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	621
Subcellular Localization	Cell membrane Single-pass type II membrane protein . Cell plate.
Protein Description	Required for cellulose microfibrils formation. Involved in cell wall assembly during cell elongation and cell plate maturation in cytokinesis. Required for secondary cell wall formation in the developing xylem. May cycle through different intracellular compartments, including plasma membrane..
Protein Sequence	MYGRDPWGGPLEINTADSATDDDRSRNLNDLDRAALSRPLDETQQSWLLGPTEQKKKKYVDLGCIIVSRKIFVWTVGTLVAAALLAGFITLIVKTVPRHHPKTPPPDNYTIALHKALKFFNAQKSGKLPKHNNVSWRGNSGLQDGKGETGSFYKDLVGGYYDAGDAIKFNFPMAYAMTMLSWSVIEYSAKYEAAGELTHVKELIKWGTDYFLKTFNSTADSIDDLVSQVGSGNTDDGNTDPNDHYCWMRPEDMDYKRPVTTCNGGCSDLAAEMAAALASASIVFKDNKEYSKKLVHGAKVVYQFGRTRRGRYSAGTAESSKFYNSSMYWDEFIWGGAWMYYATGNVTYLNLITQPTMAKHAGAFWGGPYYGVFSWDNKLAGAQLLLSRLRLFLSPGYPYEEILRTFHNQTSIVMCSYLPIFNKFNRTNGGLIELNHGAPQPLQYSVNAAFLATLYSDYLDAADTPGWYCGPNFYSTSVLRDFARSQIDYILGKNPRKMSYVVGFGTKYPRHVHHRGASIPKNKVKYNCKGGWKWRDSKKPNPNTIEGAMVAGPDKRDGYRDVRMNYNYTEPTLAGNAGLVAALVALSGEEEATGKIDKNTIFSAVPPLFPTPPPPPAPWKP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	GGPLEINTADSATDD CCCCEEECCCCCCCC	37.19	15308754
18	Phosphorylation	LEINTADSATDDDRS CEEECCCCCCCCHHH	30.51	15308754
20	Phosphorylation	INTADSATDDDRSRN EECCCCCCCCHHHCC	43.86	15308754
25	Phosphorylation	SATDDDRSRNLNDLD CCCCCHHHCCHHHHH	32.30	30291188
37	Phosphorylation	DLDRAALSRPLDETQ HHHHHHHCCCCCHHH	27.42	17317660
43	Phosphorylation	LSRPLDETQQSWLLG HCCCCCHHHHHHHCC	31.41	19880383
46	Phosphorylation	PLDETQQSWLLGPTE CCCHHHHHHHCCCCH	15.18	30291188
108	N-linked_Glycosylation	PKTPPPDNYTIALHK CCCCCCCCHHHHHHH	41.44	-
133	N-linked_Glycosylation	GKLPKHNNVSWRGNS CCCCCCCCCCCCCCC	28.99	-
216	N-linked_Glycosylation	DYFLKTFNSTADSID HHHHHHCCCCCCCHH	43.62	-
324	N-linked_Glycosylation	AESSKFYNSSMYWDE CCCCCCCCCCCCCEE	30.64	-
345	N-linked_Glycosylation	WMYYATGNVTYLNLI EEEEECCCEEEEEEE	20.71	-
408	N-linked_Glycosylation	EILRTFHNQTSIVMC HHHHHHCCCCCEEEE	42.51	-
425	N-linked_Glycosylation	LPIFNKFNRTNGGLI HHHHHCCCCCCCCCE	52.02	-
567	N-linked_Glycosylation	RDVRMNYNYTEPTLA EEEEECCCCCCCCCC	32.04	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GUN25_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GUN25_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GUN25_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CESA4_ARATH	CESA4	physical	25383767
CESA8_ARATH	IRX1	physical	25383767
CESA1_ARATH	CESA1	physical	25383767
CESA3_ARATH	CEV1	physical	25383767
CESA6_ARATH	CESA6	physical	25383767
GUN25_ARATH	GH9A1	physical	25383767
CESA1_ARATH	CESA1	physical	24948829
CESA1_ARATH	CESA1	physical	24963054
CESA3_ARATH	CEV1	physical	24963054

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GUN25_ARATH

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale analysis of in vivo phosphorylated membrane proteins byimmobilized metal ion affinity chromatography and mass spectrometry."; Nuehse T.S., Stensballe A., Jensen O.N., Peck S.C.; Mol. Cell. Proteomics 2:1234-1243(2003). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18; THR-20 AND SER-25,AND MASS SPECTROMETRY.	14506206 [Abstract]
"Phosphoproteomics of the Arabidopsis plasma membrane and a newphosphorylation site database."; Nuehse T.S., Stensballe A., Jensen O.N., Peck S.C.; Plant Cell 16:2394-2405(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-20, AND MASSSPECTROMETRY.	15308754 [Abstract]