CESA4_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CESA4_ARATH
• UniProt AC: Q84JA6
• Protein Name: Cellulose synthase A catalytic subunit 4 [UDP-forming]
• Gene Name: CESA4
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1049
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Catalytic subunit of cellulose synthase terminal complexes ('rosettes'), required for beta-1,4-glucan microfibril crystallization, a major mechanism of the cell wall formation. Involved in the secondary cell wall formation. Required for the xylem cell wall thickening..
• Protein Sequence: MEPNTMASFDDEHRHSSFSAKICKVCGDEVKDDDNGQTFVACHVCVYPVCKPCYEYERSNGNKCCPQCNTLYKRHKGSPKIAGDEENNGPDDSDDELNIKYRQDGSSIHQNFAYGSENGDYNSKQQWRPNGRAFSSTGSVLGKDFEAERDGYTDAEWKERVDKWKARQEKRGLVTKGEQTNEDKEDDEEEYLDAEARQPLWRKVPISSSKISPYRIVIVLRLVILVFFFRFRILTPAKDAYPLWLISVICEIWFALSWILDQFPKWFPINRETYLDRLSMRFERDGEKNKLAPVDVFVSTVDPLKEPPIITANTILSILAVDYPVNKVSCYVSDDGASMLLFDTLSETSEFARRWVPFCKKYNVEPRAPEFYFSEKIDYLKDKVQTTFVKDRRAMKREYEEFKVRINALVAKAQKKPEEGWVMQDGTPWPGNNTRDHPGMIQVYLGKEGAFDIDGNELPRLVYVSREKRPGYAHHKKAGAMNAMVRVSAVLTNAPFMLNLDCDHYINNSKAIRESMCFLMDPQLGKKLCYVQFPQRFDGIDLNDRYANRNIVFFDINMRGLDGIQGPVYVGTGCVFNRPALYGYEPPVSEKRKKMTCDCWPSWICCCCGGGNRNHKSDSSKKKSGIKSLFSKLKKKTKKKSDDKTMSSYSRKRSSTEAIFDLEDIEEGLEGYDELEKSSLMSQKNFEKRFGMSPVFIASTLMENGGLPEATNTSSLIKEAIHVISCGYEEKTEWGKEIGWIYGSVTEDILTGFRMHCRGWKSVYCMPKRPAFKGSAPINLSDRLHQVLRWALGSVEIFFSRHCPLWYAWGGKLKILERLAYINTIVYPFTSIPLLAYCTIPAVCLLTGKFIIPTINNFASIWFLALFLSIIATAILELRWSGVSINDLWRNEQFWVIGGVSAHLFAVFQGLLKVLFGVDTNFTVTSKGASDEADEFGDLYLFKWTTLLIPPTTLIILNMVGVVAGVSDAINNGYGSWGPLFGKLFFAFWVIVHLYPFLKGLMGRQNRTPTIVVLWSILLASIFSLVWVRIDPFLPKQTGPLLKQCGVDC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
93	Phosphorylation	ENNGPDDSDDELNIK CCCCCCCCCCCCCEE	55.10	30291188
114	Phosphorylation	SIHQNFAYGSENGDY CHHCCEECCCCCCCC	19.63	30407730
116	Phosphorylation	HQNFAYGSENGDYNS HCCEECCCCCCCCCC	18.40	30407730
135	Phosphorylation	RPNGRAFSSTGSVLG CCCCCCCCCCCCCCC	26.46	30291188
136	Phosphorylation	PNGRAFSSTGSVLGK CCCCCCCCCCCCCCC	30.27	30407730
137	Phosphorylation	NGRAFSSTGSVLGKD CCCCCCCCCCCCCCC	32.07	25561503
139	Phosphorylation	RAFSSTGSVLGKDFE CCCCCCCCCCCCCCC	17.79	30291188
374	Phosphorylation	RAPEFYFSEKIDYLK CCCCCCHHHHHHHHH	26.97	22074104
921	N-linked_Glycosylation	VLFGVDTNFTVTSKG HHHCCCCCCEEECCC	26.57	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CESA4_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CESA4_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CESA4_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CESA4_ARATH	CESA4	physical	19056734
CESA1_ARATH	CESA1	physical	22926318
CESA3_ARATH	CEV1	physical	22926318
CESA4_ARATH	CESA4	physical	22926318
CESA6_ARATH	CESA6	physical	22926318
CESA7_ARATH	IRX3	physical	22926318
CESA8_ARATH	IRX1	physical	22926318
GUN25_ARATH	GH9A1	physical	25383767
CESA4_ARATH	CESA4	physical	19258017
CESA8_ARATH	IRX1	physical	19258017

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Identification of cellulose synthase AtCesA7 (IRX3) in vivophosphorylation sites -- a potential role in regulating proteindegradation.";
Taylor N.G.;
Plant Mol. Biol. 64:161-171(2007).
Cited for: PHOSPHORYLATION AT SER-135, AND MASS SPECTROMETRY.
PubMed: 17427041