CESA6_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CESA6_ARATH
• UniProt AC: Q94JQ6
• Protein Name: Cellulose synthase A catalytic subunit 6 [UDP-forming]
• Gene Name: CESA6
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1084
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Colocalizes with CSI1 in a dynamic way.
• Protein Description: Catalytic subunit of cellulose synthase terminal complexes ('rosettes'), required for beta-1,4-glucan microfibril crystallization, a major mechanism of the cell wall formation. Involved in the primary cell wall formation. The presence of each protein CESA1 and CESA6 is critical for cell expansion. The hypocotyl elongation is based on a CESA6-dependent cell elongation in dark and a CESA6-independent cell elongation in light. The transition between these two mechanisms requires photosynthesis and PHYB, but not CRY1. The CESA6-dependent cell elongation seems to be independent of gibberellic acid, auxin and ethylene. May be involved in sensitivity to isoxaben. Associates with and moves along cortical microtubules for the process of cellulose deposition..
• Protein Sequence: MNTGGRLIAGSHNRNEFVLINADENARIRSVQELSGQTCQICRDEIELTVDGEPFVACNECAFPVCRPCYEYERREGNQACPQCKTRFKRLKGSPRVEGDEEEDDIDDLDNEFEYGNNGIGFDQVSEGMSISRRNSGFPQSDLDSAPPGSQIPLLTYGDEDVEISSDRHALIVPPSLGGHGNRVHPVSLSDPTVAAHPRPMVPQKDLAVYGYGSVAWKDRMEEWKRKQNEKLQVVRHEGDPDFEDGDDADFPMMDEGRQPLSRKIPIKSSKINPYRMLIVLRLVILGLFFHYRILHPVKDAYALWLISVICEIWFAVSWVLDQFPKWYPIERETYLDRLSLRYEKEGKPSGLSPVDVFVSTVDPLKEPPLITANTVLSILAVDYPVDKVACYVSDDGAAMLTFEALSETAEFARKWVPFCKKYCIEPRAPEWYFCHKMDYLKNKVHPAFVRERRAMKRDYEEFKVKINALVATAQKVPEDGWTMQDGTPWPGNSVRDHPGMIQVFLGSDGVRDVENNELPRLVYVSREKRPGFDHHKKAGAMNSLIRVSGVLSNAPYLLNVDCDHYINNSKALREAMCFMMDPQSGKKICYVQFPQRFDGIDRHDRYSNRNVVFFDINMKGLDGLQGPIYVGTGCVFRRQALYGFDAPKKKKGPRKTCNCWPKWCLLCFGSRKNRKAKTVAADKKKKNREASKQIHALENIEEGRVTKGSNVEQSTEAMQMKLEKKFGQSPVFVASARMENGGMARNASPACLLKEAIQVISCGYEDKTEWGKEIGWIYGSVTEDILTGFKMHSHGWRSVYCTPKLAAFKGSAPINLSDRLHQVLRWALGSVEIFLSRHCPIWYGYGGGLKWLERLSYINSVVYPWTSLPLIVYCSLPAICLLTGKFIVPEISNYASILFMALFSSIAITGILEMQWGKVGIDDWWRNEQFWVIGGVSAHLFALFQGLLKVLAGVDTNFTVTSKAADDGEFSDLYLFKWTSLLIPPMTLLIINVIGVIVGVSDAISNGYDSWGPLFGRLFFALWVIIHLYPFLKGLLGKQDRMPTIIVVWSILLASILTLLWVRVNPFVAKGGPILEICGLDCL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MNTGGRLI -------CCCCCCEE	43.72	-
11	Phosphorylation	GGRLIAGSHNRNEFV CCCEEECCCCCCCEE	14.47	25561503
136	Phosphorylation	MSISRRNSGFPQSDL CCCHHCCCCCCHHHH	39.74	26811356
145	Phosphorylation	FPQSDLDSAPPGSQI CCHHHHCCCCCCCCC	50.39	26811356
958	N-linked_Glycosylation	VLAGVDTNFTVTSKA HHHCCCCCEEEEECC	26.57	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CESA6_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CESA6_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CESA6_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CESA1_ARATH	CESA1	physical	17878303
CESA3_ARATH	CEV1	physical	17878303
CESA1_ARATH	CESA1	physical	22926318
CESA3_ARATH	CEV1	physical	22926318
CESA4_ARATH	CESA4	physical	22926318
CESA6_ARATH	CESA6	physical	22926318
CESA7_ARATH	IRX3	physical	22926318
CESA8_ARATH	IRX1	physical	22926318
GUN25_ARATH	GH9A1	physical	25383767
CESA3_ARATH	CEV1	physical	25352273
CESA1_ARATH	CESA1	physical	25352273

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.