GRM7_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRM7_RAT
• UniProt AC: P35400
• Protein Name: Metabotropic glutamate receptor 7
• Gene Name: Grm7
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 915
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity..
• Protein Sequence: MVQLGKLLRVLTLMKFPCCVLEVLLCVLAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRHVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTTNPGYRLIGQWTDELQLNIEDMQWGKGVREIPSSVCTLPCKPGQRKKTQKGTPCCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQNIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNSPAAKKKYVSYNNLVI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
98	N-linked_Glycosylation	SDPNLLPNVTLGARI CCCCCCCCCCCCHHH	39.10	-
458	N-linked_Glycosylation	YIRHVNFNGSAGTPV HHHCCCCCCCCCCCE	38.00	-
486	N-linked_Glycosylation	IFQYQTTNTTNPGYR EEEEEECCCCCCCCE	48.57	-
572	N-linked_Glycosylation	YDQRPNENRTGCQNI CCCCCCCCCCCCCCC	54.15	-
862	Phosphorylation	NVQKRKRSFKAVVTA CHHHCHHHHHHHHHH	33.85	-
889	Sumoylation	DRPNGEAKTELCENV CCCCCHHCHHHHHCC	37.92	-
900	Phosphorylation	CENVDPNSPAAKKKY HHCCCCCCHHHHHCE	22.70	28551015

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
862	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
862	S	Phosphorylation	Kinase	PRKG1	Q13976	GPS
862	S	Phosphorylation	Kinase	PRKCA	P17252	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRM7_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRM7_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FLNA_HUMAN	FLNA	physical	11943148
PIAS1_MOUSE	Pias1	physical	21288202
PIAS3_HUMAN	PIAS3	physical	21288202
CBX4_HUMAN	CBX4	physical	21288202
UBC9_HUMAN	UBE2I	physical	21288202
TBA1A_RAT	Tuba1a	physical	11953448

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.