GRC3_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRC3_SCHPO
• UniProt AC: Q9UU96
• Protein Name: Polynucleotide 5'-hydroxyl-kinase grc3
• Gene Name: grc3
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 736
• Subcellular Localization: Nucleus, nucleolus . Nucleus . Chromosome . Nuclear dots.
• Protein Description: Polynucleotide 5'-kinase required for both rRNA processing and heterochromatic gene silencing..
• Protein Sequence: MVKRQRIESSNVPLSAFAVRQLTLSKAARKKDNSSGKKRSVSEEESQDKYEDEMKTEGEFPSYKHTLVQVVVPGVDHRTKLHSESSKNDSEITPDINRSKVNPQEYSEFSVASPQTISPSLPLNLDDETVSENVPHSPQSSNDAIPVIKITEENSFRVKDTLYVGLHKDQKLAMVGTFIFRSVRGKFQLFGATYSSACMSWFPLNAPLAFATPVFSAIDNALPAMQISEYEEDSLNLRSFAVPSYSPKEHEYELEPKDILPNFETVIAFRENENGLSKIARVLPFAKRLFSFKNLLQDASSISNNFEITPESWCSFSNQLLFSTSKSDYVVPRLMVCGPKGSGKSSFSRYITNRLLQQYRHIAYLDLDPGQPEVVPSGHISLYYINSPLQGPVFARMLFPTYMLRLHLGDISPQKDPDHYIACVTRLFAEYKDYIFNQEISQKEIIPLIINCPGWIRGGGAELLSSIVDICQPTEVVYMSREDMKSSHREKKSIYQHKEYMPDFLSSRDEFQLTLLESTWQYLPDPNVNKVTSADNRMLGLLSYLYFNCNLQRWDFTTSLTACQPIATAFKGSSKGIDAVNIIGEPLNVNDVAKTINGTLMALYACDTASLDNSNTQRIVSSPEGIPLIINDGLPLDPNTSHCLGLIVLRTIDLKRNEFHFVGPLNLELIKDAYAKSLKIVLERGRLELPVYAMLDHRLAQYSELPYLDRNHDRVAVGAHRRRVRRNIIRRSTFVG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
90	Phosphorylation	SESSKNDSEITPDIN CCCCCCCCCCCCCCC	40.05	21712547
93	Phosphorylation	SKNDSEITPDINRSK CCCCCCCCCCCCHHH	15.74	24763107
113	Phosphorylation	YSEFSVASPQTISPS HCCCEECCCCCCCCC	18.51	27738172
137	Phosphorylation	VSENVPHSPQSSNDA HHHCCCCCCCCCCCC	20.68	27738172
140	Phosphorylation	NVPHSPQSSNDAIPV CCCCCCCCCCCCCCE	34.20	27738172

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GRC3_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRC3_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRC3_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RIX1_SCHPO	rix1	physical	21385875
LAS1_SCHPO	las1	physical	21385875
IPI3_SCHPO	crb3	physical	21385875
LAS1_SCHPO	las1	genetic	21385875
RAD50_SCHPO	rad50	genetic	21385875
CSX1_SCHPO	csx1	genetic	21385875

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.