RIX1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RIX1_SCHPO
• UniProt AC: P87243
• Protein Name: Pre-rRNA-processing protein rix1
• Gene Name: rix1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 828
• Subcellular Localization: Nucleus .
• Protein Description: Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA and the nucleoplasmic transit of the pre-60S ribosomal subunits. [PubMed: 21385875 Regulates pre-60S association of the critical remodeling factor mdn1 (By similarity Also required for heterochromatic gene silencing]
• Protein Sequence: MSDLLERGSLPLVKSWLAITFANEEDLPFQVPQIADILVHQKCIERLGTSENALSVRKNWCTSLTKMLQSKDFRIRWSAIILIHCTISQSWDCLVEHGATWAKLLIALLNRPETPKTLEIAMITVSKMFSSTVGRPAVTRELVTPNLPTFVNNCLRIAESGKCLCTVCSCLYQGIISHSPTFRPFVSSIRNICIKILDGEEVVPSSLQKKAAVLYASLYRCVGKGNFEDYWKQSIISILKEYHLTLDFLFQFVIEPQTYPTREENLMFPKLKGHYEETYQKALHRCRTLNLILISFLSTKTDKIVLLPINALKDLIQRVYTVQLSLPVKSVESSVQALLFMVLPHLHTLVNELTLKLFVVIPPAIILSFDSYLDSLNDCLLSESTHTGVLCSSLKLLSKFLDVTHMNVPLSKYENIVTLVLEYLANSSKGLASKSIEFSKNRGHSQKKRKTLSESQAGDTLMSSEESHQLYDSDVMDCCFSFLASILTHSIALPRLLRTKIDLCTLQISLSNPTSTVLISMHNLLLASILSPGDSQAVIVPHAIRIISGPLGLVHPDPLVASHARSSMQTIESLIHPRFPPLQKHLSPSEFENTFESRFEPVSLENQSHISPPQVDSQSEYKESSILAPSNPPFETESITDSTEIEGIKESFASTDTGLQNNSTATSENKRSESELTMSNVLSNEGDRNEEGSEINSSQPSTINHGTDHINIVSENKETTVSLLHGDVEVEETTNVALNNSQDTETKFTAIDVDFVDRPTSVVSSQIENINGDENGNTTSSVVETFEKTTDVVDEKTTSINVEGNGEDDEEEDNISLPSINLESDSDS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
587	Phosphorylation	PPLQKHLSPSEFENT CCCHHCCCHHHHCCC		28889911
589	Phosphorylation	LQKHLSPSEFENTFE CHHCCCHHHHCCCHH		25720772
603	Phosphorylation	ESRFEPVSLENQSHI HCCCCCCCCCCCCCC		28889911
608	Phosphorylation	PVSLENQSHISPPQV CCCCCCCCCCCCCCC		29996109
611	Phosphorylation	LENQSHISPPQVDSQ CCCCCCCCCCCCCCC		28889911
617	Phosphorylation	ISPPQVDSQSEYKES CCCCCCCCCCCCCCC		29996109
619	Phosphorylation	PPQVDSQSEYKESSI CCCCCCCCCCCCCCC		21712547
636	Phosphorylation	PSNPPFETESITDST CCCCCCCCCCCCCCC		21712547
638	Phosphorylation	NPPFETESITDSTEI CCCCCCCCCCCCCCE		21712547
640	Phosphorylation	PFETESITDSTEIEG CCCCCCCCCCCCEEH		21712547
642	Phosphorylation	ETESITDSTEIEGIK CCCCCCCCCCEEHHH		24763107

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RIX1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RIX1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RIX1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RIX1_SCHPO	rix1	physical	26771498

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.