GRAP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRAP_HUMAN
• UniProt AC: Q13588
• Protein Name: GRB2-related adapter protein
• Gene Name: GRAP
• Organism: Homo sapiens (Human).
• Sequence Length: 217
• Protein Description: Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway..
• Protein Sequence: MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPWYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFLWEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDFSAQDPSQLSFRRGDIIEVLERPDPHWWRGRSCGRVGFFPRSYVQPVHL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Ubiquitination	SDELAFNKGDTLKIL CCCCCCCCCCEEEEE	52.27	-
26	Ubiquitination	FNKGDTLKILNMEDD CCCCCEEEEEECCCC	47.44	-
38	Ubiquitination	EDDQNWYKAELRGVE CCCCCEEHHHHHCCC	27.31	-
50	Ubiquitination	GVEGFIPKNYIRVKP CCCCCCCCCEEEECC	58.53	-
56	Ubiquitination	PKNYIRVKPHPWYSG CCCEEEECCCCCCCC	27.97	-
76	Ubiquitination	LAEEILMKRNHLGAF HHHHHHHHCCCCEEE	46.75	-
90	Phosphorylation	FLIRESESSPGEFSV EEEEECCCCCCEEEE	51.62	-
101	Phosphorylation	EFSVSVNYGDQVQHF EEEEEEECCCCEEEE	21.66	-
109	Ubiquitination	GDQVQHFKVLREASG CCCEEEEEEEHHHCC	37.93	-
117	Ubiquitination	VLREASGKYFLWEEK EEHHHCCCEECCHHH	30.27	-
157	Phosphorylation	DEEPLLKSPGACFAQ CCCCCCCCCCCEEEE	28.65	-
210	Phosphorylation	RVGFFPRSYVQPVHL CCCCCCHHHCCCCCC	29.87	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GRAP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRAP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRAP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KIT_HUMAN	KIT	physical	8647802
EPOR_HUMAN	EPOR	physical	8647802
SOS1_HUMAN	SOS1	physical	8647802
TNFL6_HUMAN	FASLG	physical	11741599
GAB2_HUMAN	GAB2	physical	10391903
RBPMS_HUMAN	RBPMS	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.