GP107_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GP107_HUMAN
• UniProt AC: Q5VW38
• Protein Name: Protein GPR107
• Gene Name: GPR107
• Organism: Homo sapiens (Human).
• Sequence Length: 600
• Subcellular Localization: Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein .
• Protein Description: Involved in Golgi-to-ER retrograde transport. Functions as a host factor required for infection by Pseudomonas aeruginosa exotoxin A and Campylobacter jejuni CDT toxins..
• Protein Sequence: MAALAPVGSPASRGPRLAAGLRLLPMLGLLQLLAEPGLGRVHHLALKDDVRHKVHLNTFGFFKDGYMVVNVSSLSLNEPEDKDVTIGFSLDRTKNDGFSSYLDEDVNYCILKKQSVSVTLLILDISRSEVRVKSPPEAGTQLPKIIFSRDEKVLGQSQEPNVNPASAGNQTQKTQDGGKSKRSTVDSKAMGEKSFSVHNNGGAVSFQFFFNISTDDQEGLYSLYFHKCLGKELPSDKFTFSLDIEITEKNPDSYLSAGEIPLPKLYISMAFFFFLSGTIWIHILRKRRNDVFKIHWLMAALPFTKSLSLVFHAIDYHYISSQGFPIEGWAVVYYITHLLKGALLFITIALIGTGWAFIKHILSDKDKKIFMIVIPLQVLANVAYIIIESTEEGTTEYGLWKDSLFLVDLLCCGAILFPVVWSIRHLQEASATDGKGDSMGPLQQRANLRAGSRIESHHFAQADLELLASSCPPASVSQRAGITAAINLAKLKLFRHYYVLIVCYIYFTRIIAFLLKLAVPFQWKWLYQLLDETATLVFFVLTGYKFRPASDNPYLQLSQEEEDLEMESVVTTSGVMESMKKVKKVTNGSVEPQGEWEGAV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
70	N-linked_Glycosylation	KDGYMVVNVSSLSLN CCCEEEEEEEEECCC	19.28	UniProtKB CARBOHYD
85	Phosphorylation	EPEDKDVTIGFSLDR CCCCCCCEEEEEEEC	26.05	-
89	Phosphorylation	KDVTIGFSLDRTKND CCCEEEEEEECCCCC	24.93	24719451
115	Phosphorylation	YCILKKQSVSVTLLI EEEEECCCEEEEEEE	25.82	23403867
126	Phosphorylation	TLLILDISRSEVRVK EEEEEEECCCCCEEC	29.44	23403867
144	Ubiquitination	EAGTQLPKIIFSRDE CCCCCCCEEEECCCC	57.96	-
157	O-linked_Glycosylation	DEKVLGQSQEPNVNP CCCCCCCCCCCCCCC	34.41	55826041
166	O-linked_Glycosylation	EPNVNPASAGNQTQK CCCCCCCCCCCCCEE	37.66	55826047
169	N-linked_Glycosylation	VNPASAGNQTQKTQD CCCCCCCCCCEECCC	41.25	UniProtKB CARBOHYD
171	O-linked_Glycosylation	PASAGNQTQKTQDGG CCCCCCCCEECCCCC	35.71	55826051
183	Phosphorylation	DGGKSKRSTVDSKAM CCCCCCCCCCCHHHH	36.20	25072903
184	Phosphorylation	GGKSKRSTVDSKAMG CCCCCCCCCCHHHHC	32.15	25072903
211	N-linked_Glycosylation	VSFQFFFNISTDDQE EEEEEEEEECCCCCC	23.34	UniProtKB CARBOHYD
432	Phosphorylation	HLQEASATDGKGDSM HHHHHHCCCCCCCCC	42.67	-
435 (in isoform 2)	Ubiquitination	-	63.45	21906983
435	Ubiquitination	EASATDGKGDSMGPL HHHCCCCCCCCCCHH	63.45	-
536 (in isoform 2)	Ubiquitination	-	2.68	21906983
578	Phosphorylation	TTSGVMESMKKVKKV EEHHHHHHHHHEEEC	20.15	24275569
584	Ubiquitination	ESMKKVKKVTNGSVE HHHHHEEECCCCCCC	58.23	21906983
584 (in isoform 1)	Ubiquitination	-	58.23	21906983
589	Phosphorylation	VKKVTNGSVEPQGEW EEECCCCCCCCCCCC	25.94	25627689

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GP107_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GP107_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GP107_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRAF2_HUMAN	TRAF2	physical	28514442
BIRC2_HUMAN	BIRC2	physical	28514442
LCAP_HUMAN	LNPEP	physical	28514442
NDUAC_HUMAN	NDUFA12	physical	28514442
NEK7_HUMAN	NEK7	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.